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Urolithin budo ah

Urolithin A, metabolit-ka gut-microbial of ellagic acid, wuxuu sameeyaa anti-bararka, antiproliferative, iyo antioxidant guryaha. Urolithin A wuxuu kiciyaa autophagy iyo apoptosis, wuxuu xakameynayaa horumarka wareegga unugyada, wuxuuna xakameynayaa isku-darka DNA. Urolithin A lama yaqaan in laga helo meel cunto laga helo. Helitaanka bioavailability waxay inta badan kuxirantahay shakhsiyaadka microbiota, maadaama kaliya bakteeriyada qaar ay awoodaan inay u beddelaan ellagitannins urolithins

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Urolithin A Macluumaadka Saldhigga budada ah

magaca Urolithin budo ah
CAS 1143-70-0
xagiisayna 98%
Magaca kiimikada 3,8-Dihydroxybenzo [c] chromen-6-kow
Isku mid ahaanshaha 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-mid; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-mid; Midabka Castoreum I; Urolithin A; 6H-Dibenzo (B, D) pyran-6-mid, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-mid); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-mid
Formula kelli C13H8O4
Miisaanka kelli 228.2
Dhibicda Biyaha > 300 ° C
Muhiimadda InChI RIUPLDUFZCXCHM-UHFFFAOYSA-N
Form adag
Imaanshaha Budada Jaale khafiifa
Nolosha badh
milmi Dhibaatada DMSO (3 mg / mL).
kaydinta Xaaladda Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado).
Codsiga Urolithin A waa dheef-shiid kiimikaad leh ellagitannin; Farmashiyeyaasha Daawada
Dukumentiga Tijaabinta Available

 

Urolithin budo ah General Description

Budada Urolithin A waa shey dheef-shiid kiimikaad oo ka dhashay isbeddelka ellagitannins ee bakteeriyada mindhicirka waana mid soo saare u ah mitophagy. Urolithin A wuxuu mitochondria u wareejiyaa neefsashada CI-oo loo sii daayaa CII, wuxuu dheereeyaa cimriga wuxuuna hagaajiyaa shaqada muruqyada. Waxay ka tirsan tahay fasalka xeryahooda dabiiciga ah ee loo yaqaan 'benzo-coumarins' ama 'dibenzo-α-pyrones'. Horudhacyadeeda - ellagic acids iyo ellagitannins - waa meel walba oo dabiiciga ah, oo ay ku jiraan dhirta la cuni karo, sida rummaanka, strawberries, raspberries, iyo iniinta. Laga soo bilaabo 2000s, urolithin A waxaa lagu soo qaatay daraasado horudhac ah oo ku saabsan saameynteeda suurtagalka ah ee noolaha.

Budada Urolithin A waxay hagaajin kartaa tayada iyo shaqada mitochondria, waxayna kordhisaa xoogga iyo adkeysiga murqaha gabowga. Waa sheyga kaliya ee dabiiciga ah ee la cadeeyay inuu dib u bilaabayo mitophondrial autophagy iyo dib u celinta gabowga muruqyada.

Urolithins waa dheef-shiid kiimikaad microflora bini-aadam ah oo ka soo jeeda noocyada cuntada ee ellagic acid e sida ellagitannins. Waxaa lagu soo saaray

mindhicirka aadanaha, waxaana laga helay kaadida qaab ah urolithin B glucuronide kadib markii la nuugo cuntada ay ku jirto ellagitannins sida

rummaanka, strawberries, casaanka casaanka, iniinta ama khamriga cas ee da'da weyn.

Inta lagu jiro dheef-shiid kiimikaadka mindhicirka ee bakteeriyada, ellagitannins iyo punicalagins waxaa loo beddelaa urolithins, oo aan la aqoon

dhaqdhaqaaqa nafleyda ee vivo ee aadanaha. Dheef-shiid kiimikaadka Urolithins ee casiirka rummaanka ellagitannins ayaa si gaar ah u qeexaya

qanjirka 'prostate', xiidanka, iyo unugyada mindhicirka ee jiirka.

Ellagitannins waxay muujisaa bioavailability hooseeya waxaana loo beddelaa mindhicirka illaa ellagic acid iyo metabooladeeda microbiota.

Urolithins waxaa laga helaa plasma inta badan sida glucuronides oo ah uruurin hooseysa.

Wax soo saarka Urolithins wuxuu kuxiranyahay qanjirka 'microbiome enterotype'. Shakhsiyaadka soo saara urolithins-ka ayaa muujinaya tiro aad u badan

ee kooxda Clostridium leptum ee Firmicutes phylum marka loo eego Bacteroides ama Prevotella

 

Urolitin A Taariikhda budada

Daraasadaha shaybaarka, budada urolithin A waxaa lagu muujiyey inay kiciso mitophagy, taas oo ah dib-u-warshadaynta xulashada mitochondria ee autophagy, oo ah nidaam nadiifiya mitochondria oo cilladaysan ka dib waxyeelo ama walaac, oo u muuqda inuu noqdo mid aan fiicnayn inta lagu jiro da'da. Saameyntan waxaa lagu arkay noocyo kala duwan oo xayawaan ah (unugyada mammalian, jiirka iyo C. elegans).

 

Urolitin A Codsiga budada ah

Budada Urolithin A waxaa loogu talagalay in loogu isticmaalo qayb ahaan cunnooyinka la xushay ama loogu talagalay isticmaalka cuntada gaarka ah ee alaabada lagu beddelayo cuntada iyadoo lagu saleynayo waxqabadkeeda nafaqada leh ee lagu taageerayo caafimaadka guud ee mitokondrial.

 

Urolitin A budada Cilmi baaris dheeraad ah

Urolithin A lama yaqaan in laga helo cunno kasta. Waxay u samaysantaa natiijada isbeddelka asiidhyada 'ellagic acids' iyo 'ellagitannins' ee loo yaqaan 'microflora gut' ee aadanaha. Ellagic acid lafteeda waxay ka dhalataa hydrolysis-ka ellagitannins ee ku jira mindhicirka iyadoo ay jiraan biyo. [Xigasho]

Ilaha laga helo ellagitannins waa: rummaanka, lowska, miraha qaar (raspberries, strawberries, blackberries, cloudberries), shaaha, canabka muscadine, miraha badan ee kuleylaha, iyo khamri da 'ah (miiska hoose).

U beddelashada asiidhyada loo yaqaan 'ellagic acids' urolithin A waxay kuxirantahay shakhsiyaadka ka kooban microflora-ga oo si weyn ayey u kala duwanaan karaan.

 

Urolithin A Tixraaca budada

  1. Kalluumeysiga CJ, Pantuck A, Carducci MA. Dib u eegis lagu sameeyay rummaanka kansarka qanjirka 'prostate'. Kansarka Prostate Prostatic Dis. 2017 Abriil 25. doi: 10.1038 / pcan.2017.19. [Epub ka hor daabacaadda] Dib u eegid. Caawinaad PMID: 28440320.
  2. Ito H. Metabolites ee ellagitannin geraniin iyo waxqabadyadooda antioxidant. Planta Med. Julaay 2011; 77 (11): 1110-5. doi: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Dib u eegis. Caawinaad PMID: 21294073.
  3. Ishimoto H, iyo al. In vivo anti-bararka iyo guryaha antioxidant ee ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oktoobar 1; 21 (19): 5901-4.

 

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