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N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6

N-AcetylneuraminiC ACID (Sialic acids) waa qoys ka kooban sagaal kaarboon aashito monosaccharides oo si dabiici ah u dhaca dhamaadka silsiladaha sonkorta ee ku dheggan dusha sare ee unugyada iyo borotiinka milma. Jirka bini'aadamka, fiirsashada ugu badan ee sialic acid (sida N-acetylneuraminic acid) waxay ku dhacdaa maskaxda halkaas oo ay ka qaybqaadato iyada oo qayb muhiim ah ka ah qaabdhismeedka ganglioside ee synaptogenesis iyo gudbinta neerfaha.

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Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Macluumaadka Saldhiga

magaca N-AcetylneuraminiC ACID (SIALIC ACID)
CAS 131-48-6
xagiisayna 98%
Magaca kiimikada N-AcetylneuraminiC ACID
Isku mid ahaanshaha Neuraaminic acid
Formula kelli C11H19NO9
Miisaanka kelli 309.27 g / mol
Dhibicda Biyaha 185 ℃
Muhiimadda InChI SQVRNKJHWKZAKO-UHFFFAOYSA-N
Form budo
Imaanshaha budo crystal White
Nolosha badh /
milmi /
kaydinta Xaaladda Ku keydi heerkulka qolka, weel kuxiran weel hawo hawo ah, hawo hawo u dhig, ka ilaali kuleylka, iftiinka iyo huurka.
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N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 General Description

Sialic acid waa eray guud oo loogu talagalay qoys ka soo jeeda noocyada neuraminic acid, sonkorta aashitada leh ee laf-dhabarka sagaal-karbon ah Sidoo kale waa magaca xubinta ugu badan ee kooxdan, N-acetylneuraminic acid (Neu5Ac ama NANA).

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Taariikh

N-AcetylneuraminiC ACID Sialic acids waxaa laga helaa si ballaaran loogu qaybiyaa unugyada xayawaanka iyo in yar oo ka mid ah noolaha kale, laga bilaabo fangaska ilaa khamiirka iyo bakteeriyada, inta badan glycoproteins iyo gangliosides (waxay ku dhacaan dhamaadka silsiladaha sonkorta ee ku xiran meelaha dusha sare ee unugyada iyo borotiinka milma). Taasi waa sababta oo ah waxay umuuqataa inay soo muuqatay xilli dambe oo isbadal ah. Guud ahaan, dhirtu kuma jirto ama ma muujiso asiidhyada 'sialic acids'.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Mfarsamada OAction

Bini-aadamka maskaxdu waxay leedahay isku-uruurinta ugu badan ee loo yaqaan 'sialic acid', halkaas oo aashitadani ay door muhiim ah ka ciyaaraan gudbinta neerfaha iyo qaab-dhismeedka ganglioside ee synaptogenesis In ka badan 50 nooc oo ah sialic acid ayaa la yaqaan, dhammaantoodna waxaa laga heli karaa maaddooyinka loo yaqaan 'neuraminic acid' iyadoo lagu beddelayo kooxdooda amino ee mid ka mid ah kooxaha hydroxil-ka. Guud ahaan, kooxda amino waxay dhashaan acetyl ama glycolyl group, laakiin wax ka beddelid kale ayaa lagu sharaxay. Wax ka beddelladan oo ay weheliyaan isku xirnaanta ayaa muujiyey inay yihiin nudaha unugyada gaarka u ah iyo muujinta horumarka, sidaa darteed qaar ka mid ah waxaa kaliya laga helaa noocyada glycoconjugates ee unugyada gaarka ah. [3] Beddelayaasha hydroxylku si weyn ayey u kala duwanaan karaan; acetyl, lactyl, methyl, sulfate, iyo fosfate kooxo ayaa la helay.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Codsiga

  1. "Dahabka maskaxda" ee horumarka garaadka

Naasleyda, N-AcetylneuraminiC ACID (SIALIC ACID) waxaa soosaara beerka. Waa nafaqo muhiim ah oo ku jirta caanaha naaska, taas oo dhiirrigelin karta horumarinta maskaxda iyo unugyada neerfaha ee dhallaanka iyo carruurta yaryar, hagaajiya xusuusta iyo garaadka, hagaajinta xasaanadda carruurta iyo hooyooyinka;

  1. Detox antibacterial, waxay hagaajisaa difaaca jirka.

 N-AcetylneuraminiC ACID (SIALIC ACID) laguma bahdilo enzymes-ka habka dheef-shiidka, waxay sameysataa glycoproteins-ka oo xannibaya isku-xirnaanta cudur-sidayaasha (fayrasyada, bakteeriyada iyo sunta bakteeriyada) ee unugyada endocrine, waxayna hagaajin kartaa aqoonsiga unugyada, waxay sunta daacuunka ka nadiifisaa looga hortago infekshinka cudurada 'E. coli', wuxuu xakameynayaa nolosha nuska ah ee borotiinka dhiigga, sidaas darteedna wuxuu si wax ku ool ah u hagaajiyaa howlaha difaaca aadanaha. Isla mar ahaantaana, N-AcetylneuraminiC ACID (SIALIC ACID) waxay hagaajin kartaa nuugista xiidmaha fitamiinnada iyo macdanta. Hagaajinta xasaanadda ilmaha iyo hooyada; N-AcetylneuraminiC ACID (SIALIC ACID) lafteeda ayaa sidoo kale gacan ka geysata saameynta dhalashada xasilloon, waxay ka caawisaa haweenka uurka leh inay si dhib leh ku dhalaan, waxayna dedejisaa dib u soo kabashada jirka.

  1. Dib u dhig gabowga unugyada iyo kordhinta nolosha.

 Dusha sare ee unugyada aadanaha waxay leeyihiin lakab adag oo ah N-AcetylneuraminiC ACID (SIALIC ACID), nidaaminta nolosha unugyada iyo isgaarsiinta macluumaadka unugyada, yaraanta N-AcetylneuraminiC ACID (SIALIC ACID) waxay u horseedi kartaa nolosha unugyada dhiigga ee dheef-shiid kiimikaadka iyo enzyme protein ka yar. Iyo afka N-AcetylneuraminiC ACID (SIALIC ACID) waxay hagaajin kartaa isku-urursiga N-AcetylneuraminiC ACID (SIALIC ACID) ee jirka, ka hortagga daadinta dusha sare ee unugyada N-AcetylneuraminiC ACID (SIALIC ACID), daahida gabowga unugyada, wuxuu leeyahay doorka cimri dherer .

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Cilmi baaris dheeri ah

Glycoproteins-ka qaniga badan ee Sialic acid (sialoglycoproteins) waxay xiraan xulashada dadka iyo noolaha kale. Unugyada kansarka metastatic-ka waxay badanaa muujiyaan cufnaan sare oo ah glycoproteins-ka qaniga badan ee sialic acid. Muujinta xad dhaafka ah ee sialic acid ee dusha sare waxay ku abuureysaa lacag diidmo xuubabka unugyada. Tani waxay abuurtaa nacayb u dhexeeya unugyada (unugga mucaaradka) waxayna ka caawisaa unugyada kansarka marxaladda dambe inay galaan qulqulka dhiigga. Tijaabooyinkii ugu dambeeyay waxay muujiyeen jiritaanka sialic acid ee matrixka ka baxsan maqaarka ee qarsoon.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Tixraac

[1] Severi E .; Hood DW; Thomas GH (2007). "Isticmaalka aashitada Sialic ee ay keento jeermiska cudurada keena". Microbiology. 153 (9): 2817–2822. doi: 10.1099 / mic.0.2007 / 009480-0. PMID 17768226

[2] Schauer R. (2000). "Guulihii iyo caqabadihii cilmi baarista sialic acid". Glycoconj. J. 17 (7-9): 485–499. doi: 10.1023 / A: 1011062223612. PMC 7087979. PMID 11421344

[3] Racaniello, Vincent (5 Maajo 2009). "Ku xirnaanta fayraska infalawansada ee unugyada: doorka acids-ka kala duwan ee kala duwan". Blog-ga Virology. Raadin 10 April 2019.

[4] Warren, Leonard; Felsenfeld, Herbert (1962). "Biosynthesis of Acid Sialic" (PDF). Joornaalka Kiimikada Biyolojiga. 237 (5): 1421.

 

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