Budada Nikotinamide adenine dinucleotide (NAD) budada (53-84-9)

Nicotinamide adenine dinucleotide budada fiidiyowga ah

Budada NAD (53-84-9) Macluumaadka salka

Budada NAD (53-84-9) Tilmaanta Guud

Budada NAD, oo loo soo gaabiyo nicotinamide adenine dinucleotide. Qalabka loo yaqaan 'coenzyme' oo ku dhaca unugyo badan oo nool wuxuuna u shaqeeyaa sida aqbalaadda elektaroniga. Budada NAD waxaa loo istcimaalaa si isdaba-joog ah oo loo yaqaan 'NADH' oo ah oksijiin ama yareynta wakiil falcelinta dheef-shiid kiimikaadka.

Nicotinamide adenine dinucleotide Taariikhda

Coenzyme NAD+ waxaa markii ugu horreysay helay Ingiriisi biochemists Arthur Harden iyo William John Young 1906. Waxay ogaadeen in ku darista khamiir la karkariyey oo la sifeeyay ay si weyn u dardargelisay halsano khamriga laga soosaaray khamiirka aan la karkarin. Waxay ugu yeereen qodobka aan la aqoonsan ee mas'uulka ka ah saameyntan inuu yahay kayd. Iyada oo loo marayo daahirin dheer oo adag ka soosaaray khamiirka, Qodobkan kuleylka-deggan waxaa loo aqoonsaday inuu yahay fosfate sonkorta nucleotide ee Hans von Euler-Chelpin. Sanadkii 1936, saynisyahan Jarmal ah Otto Heinrich Warburg wuxuu muujiyay shaqada coenzyme nucleotide ee wareejinta hydride wuxuuna aqoonsaday qaybta nicotinamide inay tahay goobta falcelinta redox.

Faytamiinyaashii ka horreeyay ee NAD + waxaa markii ugu horreysay la aqoonsaday 1938, markii Conrad Elvehjem uu muujiyay in beerku leeyahay "lidka carrabka madow" waxqabadka ee qaabka nikotinamide. Kadib, 1939, wuxuu bixiyay cadeyntii ugu horeysay ee xoogan ee ah in niacin loo adeegsado sameynta NAD +. Horraantii 1940-yadii, Arthur Kornberg wuxuu ahaa qofkii ugu horreeyay ee lagu arko enzyme marinka biosynthetic. 1949, cilmi-baareyaasha Mareykanka Morris Friedkin iyo Albert L. Lehninger wuxuu cadeeyay in NADH ay kuxirantahay dariiqooyinka dheef-shiid kiimikaadka sida wareegga asiidhka oo leh isku-darka ATP ee fosforyaalka oksida. 1958, Jack Preiss iyo Philip Handler waxay ogaadeen dhexdhexaadiyeyaasha iyo enzymes-yada kujira biosynthesis ee NAD +; Soo-saaridda samatabbixinta ee nikotin-ka waxaa loo yaqaan dariiqa Preiss-Handler. Sannadkii 2004, Charles Brenner iyo wada-shaqeeyeyaashu waxay daaha ka rogeen jidka nicotinamide riboside kinase ee NAD +

Budada NAD (53-84-9) Farsamooyinka Ficil

Budada Nikotinamide adenine dinucleotide (NAD) waxay ku lug leedahay falcelinta redox, iyadoo xambaarta elektiroonigga laga qaado hal fal oo loo gudbo mid kale. Cofactor-ka, ayaa sidaas darteed, laga helaa laba qaab unugyada: NAD + waa maaddo sunta oksidheeye ah - waxay ka aqbashaa elektaroonikyada moleekulada kale waana ay yaraanayaan. Falcelintaani waxay samaysaa NADH, oo markaa loo istcimaali karo sidii wakiilka dhimista si loogu deeqo elektaroonigga. Jawaab-celinta elektaroniga ayaa ah shaqada ugu weyn ee NAD. Si kastaba ha noqotee, waxaa sidoo kale loo isticmaalaa qaababka kale ee unugyada, gaar ahaan qeyb yar oo ka mid ah enzymesyada kuwaas oo ku daraya ama ka saaraaya kooxaha kiimikada ah borotiinada, isbadallada kadib. Sababta oo ah muhiimadda howlahan, enzymes-yada ku lug leh dheef-shiid kiimikaadka NAD waa bartilmaameedyada daahfurka daroogada.

Codsiga Nikotinamide adenine dinucleotide Codsiga

Nikotinamide adenine budada dinucleotide (NAD) waxay u dhaqantaa sida shidaalka geedi socodyo bayooloji oo muhiim ah, sida:

1) U beddelashada cuntada tamarta

2) Dayactirka DNA burburay

3) Xoojinta nidaamyada difaaca ee unugyada

4) Dejinta saacadda gudaha jirkaaga ama garaacista garaacista jirka

Budada NAD (53-84-9) Baadhis dheeraad ah

Sababtoo ah cilmi-baarista ugu badan ee Nicotinamide adenine dinucleotide (NAD) budada waxay ka timaaddaa daraasaadka xayawaanka, ma jirto gabagabo cad oo la sameeyay oo ku saabsan waxtarkeeda aadanaha. Waa kuwan qaar ka mid ah caafimaadka suurtagalka ah faa'iidooyinka Nicotinamide adenine dinucleotide (NAD) budada:

1. Wuxuu shaqeeyaa Enzymes-ka kaas oo dhiirrigelin kara gabowga caafimaadka qaba

2. Waxay kaa caawin kartaa Ilaalinta Unugyada Maskaxda

NAD + wuxuu door muhiim ah ka ciyaaraa ka caawinta unugyada maskaxda inay si wanaagsan u da 'yaraadaan.

Unugyada maskaxda gudahooda, NAD + wuxuu gacan ka geystaa xakameynta wax soo saarka PGC-1-alpha, oo ah borotiin u muuqda inuu ka caawinayo unugyada ka hortagga culeyska oksidheerka iyo naafanimada shaqada mitokondria. Cilmi baarayaashu waxay aaminsan yihiin in walbahaarka oksidheer iyo shaqada mitochondrial ee daciifka ahi ay ku xiran yihiin cilladaha maskaxda la xiriira da'da sida Alzheimers iyo cudurka Parkinson.

3. Halista Cudurada Wadnaha ee Hoose

Gabowgu waa halista ugu weyn ee cudurada wadnaha, waana sababta ugu badan ee dadka u dhintaan. Waxay sababi kartaa xididdada dhiigga sida aortaada inay noqdaan kuwo dhumuc weyn, adag oo jilicsan. Isbedelada noocan oo kale ah waxay sare u qaadi karaan heerarka cadaadiska dhiigga waxayna qalbigaaga ka dhigi karaan mid aad u shaqeeya.

Xayawaannada, kor u qaadista NAD + waxay ka caawisay dib-u-beddelada da'da la xiriira ee halbowleyaasha

4. Waxaa laga yaabaa inay yareyso halista kansarka

Heerarka sare ee NAD + waxay ka hortagaan waxyeelada DNA iyo walaaca oksidheeka ah, ee ku xiran horumarka kansarka

5. Waxaa laga yaabaa inay kor u qaaddo da'da murqaha caafimaadka leh

Kordhinta heerarka NAD + waxay gacan ka gaysatey hagaajinta shaqada muruqyada, adkeysiga iyo adkeysiga jiirka waaweyn

Nicotinamide adenine tixraaca tixraaca

• [1] Sakuraba H, Kawakami R, Ohshima T (2005). "Marka hore Archaeal Inorganic Polyphosphate / ATP-Dependent NAD Kinase, oo ka socda Hyperthermophilic Archaeon Pyrococcus horikoshii: Dharka, Muujinta, iyo Astaamaha". Appl. Hareeraha Microbiol. 71 (8): 4352-8. doi: 10.1128 / AEM.71.8.4352-4358.2005. PMC 1183369. PMID 16085824.
• [2] Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Tallaabooyinka hore ee Biosynthesis ee NAD ee Arabidopsis waxay ku bilaabmaan Aspartate waxayna ku dhacaan Plastid". Dhirta Physiol. 141 (3): 851-7. doi: 10.1104 / pp.106.081091. PMC 1489895. PMID 16698895.
• [3] Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR (Diseembar 2009). "Falanqaynta LC / MS ee unugyada RNA waxay muujineysaa RNA-ku xiran RNA". Nat Chem Biol. 5 (12): 879–881. doi: 10.1038 / nchembio.235. PMC 2842606. PMID 19820715.
• [4] Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA (19 Diseembar 2013). "Hoos udhaca NAD + wuxuu keenaa Dawlad been abuur ah oo carqaladeysa Isgaarsiinta Nuclearka-Mitochondrial inta lagu guda jiro Da'da". Qolka. 155 (7): 1624–1638. doi: 10.1016 / j.cell.2013.11.037. PMC 4076149. PMID 24360282.
• Waxkasta oo aad u Baahan Tahay Inaad Ka Ogaato Nikotinamide Riboside Chloride

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