Alaabta
Urolithin budo ah
Urolithin A Macluumaadka Saldhigga budada ah
| magaca | Urolithin budo ah |
| CAS | 1143-70-0 |
| xagiisayna | 98% |
| Magaca kiimikada | 3,8-Dihydroxybenzo [c] chromen-6-kow |
| Isku mid ahaanshaha | 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-mid; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-mid; Midabka Castoreum I; Urolithin A; 6H-Dibenzo (B, D) pyran-6-mid, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-mid); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-mid |
| Formula kelli | C13H8O4 |
| Miisaanka kelli | 228.2 |
| Dhibicda Biyaha | > 300 ° C |
| Muhiimadda InChI | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| Form | adag |
| Imaanshaha | Budada Jaale khafiifa |
| Nolosha badh | |
| milmi | Dhibaatada DMSO (3 mg / mL). |
| kaydinta Xaaladda | Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado). |
| Codsiga | Urolithin A waa dheef-shiid kiimikaad leh ellagitannin; Farmashiyeyaasha Daawada |
| Dukumentiga Tijaabinta | Available |
Urolithin budo ah General Description
Urolitin budo waa unug dheef-shiid kiimikaad ah oo ka dhasha isbeddelka ellagitannins ee bakteeriyada mindhicirka waana kicinta mitophagy. Urolithin A waxay mitochondria ka beddeshaa CI- una wareejisaa neefsashada ay wado CII, waxay kordhisaa cimriga waxayna wanaajisaa shaqada muruqa. Waxay ka tirsan tahay fasalka xeryahooda organic ee loo yaqaan benzo-coumarins ama dibenzo-a-pyrones. Horudhacyadeeda - ellagic acids iyo ellagitannins - waa meel kasta oo dabiici ah, oo ay ku jiraan dhirta la cuni karo, sida rummaannada, strawberries, raspberries, iyo walnuts. Laga soo bilaabo 2000-meeyadii, urolitin A waxay ahayd maaddo daraasado horudhac ah oo ku saabsan saamaynta bayooloji ee suurtogalka ah.
Budada Urolithin A waxay hagaajin kartaa tayada iyo shaqada mitochondria, waxayna kordhisaa xoogga iyo adkeysiga murqaha gabowga. Waa sheyga kaliya ee dabiiciga ah ee la cadeeyay inuu dib u bilaabayo mitophondrial autophagy iyo dib u celinta gabowga muruqyada.
Urolithins waa dheef-shiid kiimikaad microflora bini-aadam ah oo ka soo jeeda noocyada cuntada ee ellagic acid e sida ellagitannins. Waxaa lagu soo saaray
mindhicirka aadanaha, waxaana laga helay kaadida qaab ah urolithin B glucuronide kadib markii la nuugo cuntada ay ku jirto ellagitannins sida
rummaanka, strawberries, casaanka casaanka, iniinta ama khamriga cas ee da'da weyn.
Inta lagu jiro dheef-shiid kiimikaadka mindhicirka ee bakteeriyada, ellagitannins iyo punicalagins waxaa loo beddelaa urolithins, oo aan la aqoon
dhaqdhaqaaqa nafleyda ee vivo ee aadanaha. Dheef-shiid kiimikaadka Urolithins ee casiirka rummaanka ellagitannins ayaa si gaar ah u qeexaya
qanjirka 'prostate', xiidanka, iyo unugyada mindhicirka ee jiirka.
Ellagitannins waxay muujisaa bioavailability hooseeya waxaana loo beddelaa mindhicirka illaa ellagic acid iyo metabooladeeda microbiota.
Urolithins waxaa laga helaa plasma inta badan sida glucuronides oo ah uruurin hooseysa.
Wax soo saarka Urolithins wuxuu kuxiranyahay qanjirka 'microbiome enterotype'. Shakhsiyaadka soo saara urolithins-ka ayaa muujinaya tiro aad u badan
ee kooxda Clostridium leptum ee Firmicutes phylum marka loo eego Bacteroides ama Prevotella
Urolitin A Taariikhda budada
Daraasadaha shaybaarka, budada urolithin A waxaa lagu muujiyey inay kiciso mitophagy, taas oo ah dib-u-warshadaynta xulashada mitochondria ee autophagy, oo ah nidaam nadiifiya mitochondria oo cilladaysan ka dib waxyeelo ama walaac, oo u muuqda inuu noqdo mid aan fiicnayn inta lagu jiro da'da. Saameyntan waxaa lagu arkay noocyo kala duwan oo xayawaan ah (unugyada mammalian, jiirka iyo C. elegans).
Urolitin A Codsiga budada ah
Budada Urolithin A waxaa loogu talagalay in loogu isticmaalo qayb ahaan cunnooyinka la xushay ama loogu talagalay isticmaalka cuntada gaarka ah ee alaabada lagu beddelayo cuntada iyadoo lagu saleynayo waxqabadkeeda nafaqada leh ee lagu taageerayo caafimaadka guud ee mitokondrial.
Urolitin A budada Cilmi baaris dheeraad ah
Urolithin A lama yaqaan in laga helo cunno kasta. Waxay u samaysantaa natiijada isbeddelka asiidhyada 'ellagic acids' iyo 'ellagitannins' ee loo yaqaan 'microflora gut' ee aadanaha. Ellagic acid lafteeda waxay ka dhalataa hydrolysis-ka ellagitannins ee ku jira mindhicirka iyadoo ay jiraan biyo. [Xigasho]
Ilaha laga helo ellagitannins waa: rummaanka, lowska, miraha qaar (raspberries, strawberries, blackberries, cloudberries), shaaha, canabka muscadine, miraha badan ee kuleylaha, iyo khamri da 'ah (miiska hoose).
U beddelashada asiidhyada loo yaqaan 'ellagic acids' urolithin A waxay kuxirantahay shakhsiyaadka ka kooban microflora-ga oo si weyn ayey u kala duwanaan karaan.
Urolithin A Tixraaca budada
- Kalluumeysiga CJ, Pantuck A, Carducci MA. Dib u eegis lagu sameeyay rummaanka kansarka qanjirka 'prostate'. Kansarka Prostate Prostatic Dis. 2017 Abriil 25. doi: 10.1038 / pcan.2017.19. [Epub ka hor daabacaadda] Dib u eegid. Caawinaad PMID: 28440320.
- Ito H. Metabolites ee ellagitannin geraniin iyo waxqabadyadooda antioxidant. Planta Med. Julaay 2011; 77 (11): 1110-5. doi: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Dib u eegis. Caawinaad PMID: 21294073.
- Ishimoto H, iyo al. In vivo anti-bararka iyo guryaha antioxidant ee ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oktoobar 1; 21 (19): 5901-4.
