Alaabta
Budada Urolithin B (1139-83-9)
Urolithin B macluumaadka saldhigga budada
| magaca | Budada Urolithin B |
| CAS | 1139-83-9 |
| xagiisayna | 98% |
| Magaca kiimikada | 3-Hydroxy-6H-dibenzo [b, d] pyran-6-one |
| Isku mid ahaanshaha | AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR |
| Formula kelli | C13H8O3 |
| Miisaanka kelli | 212.2 g / mol |
| Dhibicda Biyaha | 247 ° C |
| Muhiimadda InChI | Wxuqmtrhthpnopnoxbv-udfffayoysa-n |
| Form | Solid |
| Imaanshaha | Budada khafiifka ah |
| Nolosha badh | / |
| milmi | Xaaqin 5mg / mL, cad cad (kuleyl) |
| kaydinta Xaaladda | 2-8 ° C |
| Codsiga | Urolithin B waa dheef-shiid kiimikaad maaddada microbial-ka ah ee loo yaqaan 'ellagitannis' wuxuuna muujiyaa firfircooni firfircoon oo ka-hortagga sunta-jirka iyo dhaqdhaqaaqa ka-hortagga jirka ee ku xiran nidaamka deynta iyo shuruudaha. Urolithin B sidoo kale waxay soo bandhigi kartaa waxqabadka estrogenic iyo / ama waxqabadka anti-estrogenic. |
| Dukumentiga Tijaabinta | Available |
Budada Urolithin B Sharaxaada Guud
Urolithin B waa urolithin, nooc ka mid ah xeryahooda phenolic-ka ee lagu soo saaro bini-aadamka ka dib marka la nuugo cuntooyinka ay ku jirto ellagitannins-ka sida rummaanka, miro guduudka ah, miraha guduudka cas, walnuts ama khamriga cas ee oak-cas. Urolithin B waxaa laga helaa kaadida oo ah qaab urolithin B glucuronide.
Urolithin B waa mid ka mid ah dheef-shiid kiimikayaasha microbial ee ellagitannins, waxayna leedahay saameyn anti-barar iyo antioxidant. Urolithin B waxay xannibaysaa waxqabadka NF-κB iyadoo la yareynayo fosfooraska iyo nabaad-guurka ee IαB and, waxayna yareysaa fosfooraska JNK, ERK, iyo Akt, waxayna wanaajisaa fosfooraska AMPK. Urolithin B sidoo kale waa haye xaddiga muruqyada lafaha. Urolithin B sidoo kale waxay soo bandhigi kartaa waxqabadka estrogenic iyo / ama waxqabadka anti-estrogenic.
Taariikhda budada Urolitin B
Urolithin B waxaa loo isticmaali karaa daawo ahaan antitumor iyo anticancer. Urolithin B (CAS NO: 1139-83-9) waa urolithin, waxaa sidoo kale lagu soo saaraa xiidmaha bini'aadamka ka dib marka la nuugo ellagitannins ka rummaanka. Urolithin B wuxuu yareyn karaa dhaawaca muruqyada ee soo maray inta lagu gudajiray jimicsi xoog leh wuxuuna ka ilaalin karaa muruqyada cadaadiska ay keeneen cuntada dufanka badan.
Budada Urolithin B sidoo kale waa dheef-shiid kiimikaad hoose oo ah ellagitannis waxayna soo bandhigtaa firfircoonida anti-oxidant iyo pro-oxidant iyadoo kuxiran nidaamka baaritaanka iyo xaaladaha. Urolithin B sidoo kale wuxuu soo bandhigi karaa firfircoonida estrogenic iyo / ama anti-estrogenic. Waxay leedahay saameyn anti-bararka iyo antioxidant. Urolithin B sidoo kale waxaa loo isticmaalaa inuu ahaado jaangooyaha muruqa lafaha.
Iyo Urolithin B ayaa la muujiyey inay ka gudubto xayndaabka maskaxda ee dhiigga, oo laga yaabo inay leedahay neuroprotective saamaynta ka dhanka ah Cudurka Alzheimers.
Urolithin B budada cilmi baaris dheeraad ah
Urolithin B wuxuu yareyn karaa dhaawaca muruqyada ee soo maray inta lagu gudajiray jimicsi xoog leh wuxuuna ka ilaalin karaa muruqyada cadaadiska ay keeneen cuntada dufanka badan. Cilmi-baaris caafimaad oo ku saabsan Urolithin B ee jiirka ayaa lagu ogaaday inay kor u qaadday koritaanka iyo kala-duwanaanta iyadoo la kordhinayo isku-darka borotiinka. Waxay muujisay karti lagu xakameynayo marinka ubiquitin-proteasome (UPP), habka ugu muhiimsan ee loo yaqaan 'catabolism protein'. Waxay sidoo kale sababtay hypertrophy muruqyada waxayna yareysay atrophy murqo.
Marka la barbardhigo testosterone, Urolithin B markii lagu qaatay 15 uM waxay kordhisay waxqabadka xasaasiyadeed ee androgen by 90% halka testosterone ay awood u laheyd oo keliya inay ku guuleysato waxqabadka soo-dhoweynta kordhay ee 50% at 100uM. Tani waxay ka dhigan tahay inay wax badan ka yar tahay Urolithin B si loo kordhiyo firfircoonaanta firfircoonida si wax ku ool ah ka dibna xaddiga sare ee testosterone oo kordhiya waxqabadka androgen si waxtar leh.
Intaa waxaa sii dheer, ugu waxtarka badan ee 15uM ee Urolithin B oo ah isugeynta borotiinka muruqyada weyn iyada oo loo marayo 96% marka la barbar dhigo 100uM ee insulin, taas oo ah isugeynta borotiinka muruqyada weyn ee ugu waxtarka badan 61%. Aamminaaddu waxay tahay in ay qaaddo wado dheer aad uga yar Urolithin B si loo dheereysto isku-darista borotiinka muruqyada oo leh heer sare oo wax ku ool ah.
Daraasadahaani waxay muujinayaan in Urolithin B ay xakameyn karto catabolism-ka protein-ka halka isla mar ahaantaana ay kordhiso isku-darka borotiinka, waa maaddo dabiici ah oo ka caawisa dhismaha muruqyada caatada ah iyadoo ka hortagaysa burburka murqaha.
Urolithin B Powder 1139-83-9 Tixraac
- 1. Kallio, T., et al.: J. Agr. Chem Cuntada., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Chem Cuntada., 54, 1611 (2006); Bialonska, D., iyo al.: J. Agr. Chem Cuntada., 57, 10181 (2009)
- Rodriguez J, iyo al. Urolithin B, oo ah jaangooyaha cusub ee la ogaaday ee muruqyada muruqyada. J Cachexia Sarcopenia Murqo. 2017 Agoosto; 8 (4): 583-597.
- Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nofeembar 2009). "Urolithins, dheef-shiid kiimikaad-dhiska microbial-ka ee 'Pomegranate ellagitannins', ayaa soo bandhigaya waxqabad xooggan oo ka-hortagga antioxidant-ka oo ku jira baaritaanka unugyada ku saleysan". J Beeraha Chem Chem. 57 (21): 10181-6.
