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Iibso Nefiracetam (77191-36-7) hplc≥98% - Nootropics Wisdompowder

Budada Nefiracetam (77191-36-7)

Budada Nefiracetam waxay kor u qaadaa caafimaadka maskaxda waxayna u shaqaysaa siyaabo dhowr ah. Laakiin laba si gaar ah ayey u taagan yihiin.Nefiracetam wuxuu xoojiyaa xusuusta. Nefiracetam wuxuu kaloo kor u qaadaa waxqabadka acetylcholine (ACh) maskaxdaada. Si looga fogaado "madax xanuun racetam" hubi inaad ku dhejiso Nefiracetam oo leh il choline wanaagsan sida CDP-Choline ama Alpha GPC. Bacdamaa Nefiracetam yahay dufanka loo yaqaan 'nootropic fat-soluble, waa inaad ku qaadataa cunto ay ku jiraan dufan caafimaad leh. Ama qaado yar oo bikro ah oo dheeraad ah, qumbaha qabow lagu iibiyey ama saliida saytuunka. Ama dufanka kale ee caafimaadka la mid ah si loo hubiyo in si dhakhso leh loo nuugo.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Budada Nefiracetam (77191-36-7) fiidiyaha

 

Macluumaadka Saldhigga Budada ee Nefiracetam

magaca Budada Nefiracetam
CAS 77191-36-7
xagiisayna 98%
Magaca kiimikada Nefiracetam 77191-36-7

N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide ,Translon ,DM 9384
Isku mid ahaanshaha (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
Formula kelli C14H18N2O2
Miisaanka kelli 246.3 g / mol
Dhibicda Biyaha 151-155 ° C
Muhiimadda InChI NGHTXZCKLWZPGK-UHFFFAOYSA-N
Form Solid
Imaanshaha cad ilaa budo cad-cad
Nolosha badh saacadood 3-5
milmi Ka shaqee xNUMX mM ee DMSO iyo 100 mM ee ethanol
kaydinta Xaaladda Dukaanka RT
Codsiga Nefiracetam waa xarunta loo yaqaan 'organooxygen compound' iyo xarunta loo yaqaan 'organonitrogen compound'. Waxay ka timaadaa alfa-amino acid.Its Nootropics
Dukumentiga Tijaabinta Available

 

Budada Nefiracetam Qeexida Guud

Budada Nefiracetam waxaa loo tixgeliyaa inay aad uga xoog badan tahay Piracetam. Sida nootropic, waxay gacan ka geysaneysaa kordhinta feejignaanta, feejignaanta, garashada, barashada iyo kor u qaadista xusuusta.Nefiracetam waxaa loo isticmaalaa dawooyinka dhakhtar qoray ee Japan. Waxayna la mid tahay qaab dhismeedka Piracetam oo leh koox phenyl iyo laba methyl oo lagu daray amine of Piracetam. Nefiracetam, sida cunsuriyada oo dhan nootropics, wuxuu udub dhexaad u yahay pyrrolidone nucleus. Qaab dhismeedka Nefiracetam wuxuu la mid yahay Aniracetam

 

Budada Nefiracetam (77191-36-7) Taariikh

Nefiracetam waxaa soo saaray Daiichi Seiyaku 1990-yadii si loogu daaweeyo cudurada maskaxda ku dhaca. Sanadkii 1999kii, Nefiracetam wuxuu ku jiray wajiga II tijaabooyin caafimaad oo gudaha Mareykanka ah si loogu daaweeyo dhibaatooyinka garashada oo ay sabab u tahay faalig, iyo shirkadda 'Alzheimer' ee nooca 'dementia'. dufanka-soluble halka Piracetam waa biyo-L. Molecule-fat-millaaya waxay ka gudbayaan xannibaadda-maskaxda maskaxda si ka sahlan molikaliyeyaasha biyaha ku-milma.

Labada Nefiracetam iyo Piracetam labadaba waa xoojiyayaal garasho. Labaduba waxay leeyihiin tayo aasaasi ah. Labada cunsuriyad waxay awoodaan inay horumariyaan waxbarashada iyo xusuusta. Labaduba waxay awoodaan inay ka hortagaan dhaawac maskaxda.

 

Nefiracetam (77191-36-7) Farsamooyinka Ficil

Nefiracetam wuxuu leeyahay faa'iidooyin dheeraad ah oo aan lala wadaagin Piracetam. Nefiracetam wuxuu yareyn karaa walaaca iyo diiqadda. Oo soo bandhigaysa dhowr xasuus oo kale oo kor u qaadaya tayada Piracetam.Nefiracetam waxay kordhisaa xaddiga waqtiga kanaalshiyamyada neurons-ka ay furan yihiin. Loogu talagalay borotiinka kinase A (PKA) iyo Gi alpha subunit (Gi / o protein), calaamadaynta waxaa lagu wanaajiyey neuroreceptor ka madaxbanaan synapse. Wadada kalsiyamka kalsiyamku waxay muhiim u tahay awoodda muddada dheer (LTP) iyo samaynta xusuusta muddada-dheer. PKCα waxay kuxirantahay tilmaamta glutamate.And Nefiracetam wuxuu ku shaqeeyaa Ca2 + / proteinod ku tiirsaneyaasha protein kinase II (CaMKII) kaasoo muhiim u ah sameynta xusuusta. Mar labaad waxay kuxirantahay tilmaamida glutamate.Finally, Nefiracetam waxay awood u leedahay dadka qaata acetylcholine ee kudhaca hibooyinka loo yaqaan 'hunguriga siideynta' iyo 'LTP'. Piracetam lama wadaagto xusuustaan ​​kor u qaadista tayada. Qeybta hoose waa Nefiracetam waxay u muuqataa inay tahay xoojinta xusuusta aadka u badan taas oo ah Piracetam asalka nootropic.

 

Nefiracetam (77191-36-7) Codsashada

Neuroprotection: Nefiracetam wuxuu gacan ka geystaa xakameynta calaamadaha NMDA kaasoo ka ilaaliya heerarka xad-dhaafka ah ee xad-dhaafka ah. 'Glutamate' waa galka maskaxda ee xad dhaafka ah. Sumowga badan ee jirka (glutamate) wuxuu waxyeelo u geystaa neerfayaasha iyo maskaxda oo dhan.

Neurotransmitters: Nefiracetam wuxuu wax ka beddelaa heerarka GABA ee maskaxda. Yaraynta GABA marka uu aad u sarreeyo, iyo kordhinta heerarka GABA haddii ay aad u hooseeyaan. Soosaarid diirad u eg xasilooni iyo yareyn walaac. Nefiracetam wuxuu dheereynayaa furitaanka marinnada kaalshiyamka. Ka dhigista neurotransmitters-ka firfircoon muddo dheer. Hagaajinta sameynta xusuusta iyo dib u soo celinta.

Acetylcholine: Nefiracetam potentiates receptors nicotinic acetylcholine. Kordhinta sii deynta GABA iyo 'glutamate'. Soosaarida saameyn deggan iyadoo la hagaajinayo neuroplasticity iyo kor u qaadista barashada iyo xusuusta.

Nefiracetam (DM-9384, N- (2, 6-dimethylphenyl) -2- (2-oxopyrrolidine-1-yl) -acetamide) waxay ku jirtaa qoyska racetam-ka ee xeryahooda nootropic. Waa duf-dufan leh.

Heerka 'racetam-ka nootropics' waxay ku leedahay xudunta pyrrolidone nucleus salkeeda. 'Nefiracetam' waa isku-darka cholinergic, taasoo la micno ah inuu saameyn ku yeesho heerarka acetylcholine ee maskaxda.

Nefiracetam waxaa loo isticmaalaa in lagu qoro dawo Japan. Waxaa loo iibiyaa sidii alaab la soo iibsado, oo ah xarun aan xadidneyn oo Mareykanka dhexdeeda ah. Laakiin maaha sidii cunto dheeri ah. Mid ka mid ah xeryahooda nootropic-ka ugu dambeeyay, waxaa loo yaqaanaa kobcinta garashada. Waxaana loo yaqaanaa dawacadeeda xasaasiga ah, ama waxyeelada walaaca fekerka.

 

Nefiracetam (77191-36-7) Daraasad dheeri ah

Nefiracetam wuxuu kor u qaadaa caafimaadka maskaxda iyo shaqada dhowr siyaabood. Laakiin laba si gaar ah ayaa u taagan.

Nefiracetam wuxuu xoojiyaa xusuusta. Dhowr daraasadood iyo tijaabooyin caafimaad, cilmi baadhayaashu waxay xustay saameynta anti-amnesia ee Nefiracetam. Oo iyagu waxay ku yimaadeen aragtidaas iyaga oo garanaya Nefiracetam oo la fal galaya shaqsiyaadka aqbalaya acetylcholine maskaxda.

Hal daraasad oo laga sameeyay shabakada daryeelka caafimaadka ee Albert Einstein ee ku taal Philadelphia waxay la shaqeysay bakaylaha waaweyn. Baarayaasha waxay adeegsadaan farsamo loogu magac daray "sawirka xuubka xuubka (NM) / jawaabta indhaha" ee bakaylaha kaas oo loo adeegsado sheybaarka si loo barto cilladaha la xiriira da'da.

Xaaladdan oo kale, kooxdu waxay adeegsadeen Nefiracetam si ay u darsaan saameynta ay ku leedahay sii-haynta iyo dib-u-qorista. Saynisyahannadu waxay 5, 10 ama 15 mg / kg oo Nefiracetam ah ku siiyeen 34 bakayle "hawlgab ah" muddo 15 maalmood ah.

 

Nefiracetam (77191-36-7) Tixraac

  • Crespi F. “Nefiracetam. Daiichi Seiyaku. ” Fikradda hada ee Maandooriyaha Baarista. 2002 May; 3 (5): 788-93.
  • Malenka RC, Kauer JA, Perkel DJ, Nicoll RA “Saamaynta kaalshiyamka postsynaptik ee ku saabsan gudbinta synaptika - doorka ay ku leedahay awoodda muddada fog” Isbeddellada ku dhaca Neurosciences Volume 12, Issue 11, p444–450, 1989
  • Kim H., Han SH, Quan HY, Jung YJ, An J., Kang P., Park JB, Yoon BJ, Seol GH, Min SS “Bryostatin-1 waxay sare u qaadeysaa awoodda muddada dheer iyadoo la adeegsanayo firfircoonida PKCα iyo PKCε ee hibitaalka. . ” Neuroscience. 2012 Dec 13; 226: 348-55.
  • Moriguchi S., Han F., Shioda N., Yamamoto Y., Nakajima T., Nakagawasai O., Tadano T., Yeh JZ, Narahashi T., Fukunaga K. “Nefiracetam activation of CaM kinase II iyo protein kinase C Waxaa qoray NMDA iyo metabotropic receptors gintamate-ka saliidaha leh ee jiirka ku badan. ” Journal of Neurochemistry. 2009 Jul; 110 (1): 170-81
  • Tilmaanta isbarbardhiga kama dambaysta ah ee Racetam Nootropics
  • Tilmaamaha Kuufiyeyaasha ee ugu fiican ee loo yaqaan 'Nootropic Stack Guide': Wax kasta oo aad u Baahan Tahay Inaad Ogaato

 

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