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Iibso CAD-31 (2071209-49-7) hplc≥98% - Antiaging Wisdompowder

Budada CAD-031 (2071209-49-7)

Budada CAD-031 (CAD031) waa curiyaha maskaxda cusub, J147-ka soo kiciyay oo kor u qaaday waxqabadka neurogenic ee ka sarreeya J147 ee unugyada hormarka neerfaha ee bini aadamka (NPCs); sidoo kale waxay kicineysaa kala qeybinta NPC-yada aag hoosaadyada ee jiirarkii hore ee APPswe / PS1E9; waxay ka badbaadisaa neerfayaasha aasaasiga ah ee cudurada neerfaha ee loo yaqaan 'oxytosis', waxayna si wax ku ool ah u dhimaan culeyska sunta ee loo yaqaan 'EC50 of 20 nM;' sidoo kale waxay ka hortageysaa luminta dheef-shiid kiimikaadka jirka ee keena dhimashada unugyada neuron-ka ee qaabka ischemia-ga leh ee loo yaqaan 'EC50 of 47 nM'; bar-tilmaameedka dheef-shiid kiimikaad dufan iyo barar, wuxuu soosaaraa wax ku ool ahaanta daweynta xagga garashada iyo qiyaasaha jir ahaaneed ee habka moodeelka AD.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Budada CAD-031 (2071209-49-7) fiidiyaha

 

Budada CAD-031 (2071209-49-7) Xogta Saldhigga

magaca Budada CAD-031
CAS 2071209-49-7
xagiisayna 98%
Magaca kiimikada Acetic acid, 2,2,2-trifluoro-, (2E) -1- (2,4-dimethylphenyl) -2 - [[3- (trifluoromethoxy) phenyl] methylene] hydrazide
Isku mid ahaanshaha CAD 31); CAD-031 (CAD031)
Formula kelli C18H14F6N2O2
Miisaanka kelli 404.312
Dhibicda Biyaha Xog La'aan
Muhiimadda InChI Xog La'aan
Form Xog La'aan
Imaanshaha Xog La'aan
Nolosha badh Xog La'aan
milmi Xog La'aan
kaydinta Xaaladda -20 ° C Bisha Lixaad; 12 ° C XUMAYA Bisha Lixaad
Codsiga Xog La'aan
Dukumentiga Tijaabinta Available

 

Budada CAD-031 (2071209-49-7) Sifeynta Guud

Budada CAD-031 waxay ku fiicnayd macnaha guud ee ka hortagga qaar ka mid ah dhacdooyinka sunta ah ee ku dhaca cudurrada neerfaha ee da'da la xiriira. Budada CAD-031 waxay leedahay astaamo neuroprotective awood leh oo ku jira lix tijaabo oo unugyada dareemayaasha oo kala duwan oo u ekeysiiya sunta lagu arkay maskaxda hore. Daraasadaha sunta sunta ee dawooyinka iyo horudhaca ah waxay muujinayaan in CAD-031 ay tahay mid maskaxda geli karta oo ay u badan tahay inay badbaado tahay. Markii la quudiyo gabow, astaamaha APPswe/PS1ΔE9 AD jiirrada laga bilaabo 10 bilood jir 3 bilood oo dheeri ah oo ku jira qaab daweynta cudurka, waxaa yaraaday xusuusta iyo maskaxda caabuq, iyo sidoo kale kororka muujinta borotiinka synaptic. Xogta dheef-shiid kiimikaad-yar-yar ee maskaxda iyo plasma ayaa muujisay in saameynta ugu weyn ee CAD-031 ay ku qotonto dheef-shiid kiimikaad caabuq. Falanqaynta dariiqa xogta muujinta hidda-wadaha ayaa muujisay in CAD-031 ay saameyn weyn ku yeelatay sameynta synapse iyo waddooyinka dheef-shiid kiimikaadka AD.

 

CAD-031 (2071209-49-7) Codsi

  1. CAD-031 si weyn ayaa looga hortagaa
  2. CAD-031 waxay leedahay astaan ​​caafimaad iyo badbaado oo heer sare ah
  3. CAD-031 wuxuu dib u rogaa dhinacyada qaarkood cillad garashada jiirkii hore ee transgenic AD
  4. Falanqaynta RNA-seq waxay soo jeedinaysaa in CAD-031 ay wax ka beddesho bararka, caafimaadka synaptic, iyo shiid
  5. CAD-031 wuxuu yareeyaa caabuqa waxayna kordhisaa calaamadaha neurogenesis iyo synapses
  6. AD-31 waxay beegsataa dheef-shiid kiimikaad

 

CAD-031 (2071209-49-7) Tixraac

  1. Daugherty D, et al. Alzheimers Res Ther. 2017 Jul 14; 9 (1): 50.
  2. Chen Q, M M, Dargusch R, Roberts A, Riek R, Eichmann C, et al. Daawooyinka neerfaha ee 'neurotrophic' ee loogu talagalay xoojinta garashada iyo cudurka 'Alzheimer'. PLoS Mid. 2011; 6 (12): e27865. doi: 10.1371 / journal.pone.0027865. [Maqaal bilaash ah PMC] [PubMed] [CrossRef] [Google Scholar]
  3. Kahor M, Dargusch R, Ehren JL, Chiruta C, Schubert D. Xarunta neurotrophic J147 way rogmaysaa kala dhantaalnaan fahanka Jiirarka cudurka Alzheimers ee da'da ah. Alzheimers Res Ther. 2013; 5 (3): 25. doi: 10.1186/alzrt179. [Maqaalka bilaashka ah ee PMC] [PubMed] [CrossRef] [Aqoonyahan Google]
  4. Kahor M, Chiruta C, Currais A, Goldberg J, Dargusch R, Maher P, et al. Dib ugu noqo mustaqbalk a baarista cudurka loo yaqaan 'phenotypic screening'. ACS Chem Neurosci. 2014; 5 (7): 503– doi: 10.1021 / cn500051h. [Maqaal bilaash ah PMC] [PubMed] [CrossRef] [Google Scholar]
  5. Kahor M, Goldberg J, Chiruta C, Farrokhi C, Kopynets M, Roberts AJ, et al. Xulashada suurtagalnimada neurogenic oo bedel u ah daahfurka daroogada cudurka Alzheimers. Qaybta Alzheimers. 2016; 12 (6): 678– doi: 10.1016 / j.jalz.2016.03.016. [Maqaal bilaash ah PMC] [PubMed] [CrossRef] [Google Scholar]
  6. Currais A, Goldberg J, Farrokhi C, Chang M, Kahor M, Dargusch R, et al. Qaabab kala jaad jaad ah oo balaaran ayaa loo fahmi karaa xiriirka ka dhexeeya gabowga iyo jahawareerka. Da '. 2015; 7 (11): 937– doi: 10.18632 / gabowga.100838. [Maqaal bilaash ah PMC] [PubMed] [CrossRef] [Google Scholar]

 

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