Products
Procyanidin Powder
Procyanidin B2 Xogta Saldhiga Kiimikada Budada
| magaca | Procyanidin B2 |
| CAS | 29106-49-8 |
| xagiisayna | 98% |
| Magaca kiimikada | (2R,2’R,3R,3’R,4R)-2,2′-bis(3,4-dihydroxyphenyl)-3,3′,4,4′-tetrahydro-[4,8′-bi-2H-1-benzopyran]-3,3′,5,5′,7,7′-hexol |
| Isku mid ahaanshaha | Procyanidin B2 Procyanidol B2 Proanthocyanidin B2 (+)-Procyanidin B2 |
| Formula kelli | C30H26O12 |
| Miisaanka kelli | 578.5 |
| Boling Point | |
| Muhiimadda InChI | XFZJEEAOWLFHDH-NFJBMHMQSA-N |
| Form | budo |
| Imaanshaha | budo cad |
| Nolosha badh | / |
| milmi | Procyanidin B2 waxay ku milmi kartaa dareerayaasha organic sida ethanol, DMSO, iyo dimethyl formamide. Solubility ee procyanidin B2 ee dareerayaashan waa qiyaastii 30 mg/ml. |
| kaydinta Xaaladda | ku kaydsan weel xidhan oo ay ka baxeen kulaylka, iftiinka iyo qoyaanka. |
| Codsiga | supplements cuntada |
| Dukumentiga Tijaabinta | Available |
Procyanidin C1 Macluumaadka Saldhigga Kiimikada Budada
| magaca | Procyanidin C1 |
| CAS | 37064-30-5 |
| xagiisayna | 98% |
| Magaca kiimikada | (2R,3R,4S)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol |
| Isku mid ahaanshaha | Procyanidin C1 Procyanidol C1 Proanthocyanidin C1 Cinnamtannin A1 |
| Formula kelli | C45H38O18 |
| Miisaanka kelli | 866.8 |
| Boling Point | |
| Muhiimadda InChI | MOJZMWJRUKIQGL-XILRTYJMSA-N |
| Form | budo |
| Imaanshaha | budo cad |
| Nolosha badh | |
| milmi | Procyanidin C1 waxay ku milmaysaa dareerayaasha organic sida ethanol, DMSO iyo dimethyl formamide, kaas oo ay tahay in lagu nadiifiyo gaas aan shaqaynayn. Solubility ee procyanidin C1 ee dareerayaashan waa qiyaastii 30mg/ml |
| kaydinta Xaaladda | ku kaydsan weel xidhan oo ay ka baxeen kulaylka, iftiinka iyo qoyaanka. |
| Codsiga | supplements cuntada |
| Dukumentiga Tijaabinta | Available |
Procyanidin Powder General Description
Procyanidins waa xubno ka mid ah proanthocyanidin (ama tannins isku urursan) ee flavonoids. Waxay yihiin xeryahooda oligomeric, oo laga sameeyay catechin iyo molecules epicatechin. Waxay soo saaraan cyanidiin marka laga saaro xaaladaha oksaydhka.
Budada Procyanidin B2 waa proanthocyanidin ka kooban laba molecules oo ah (-)-epicatechin oo ay ku soo biireen dammaanad u dhaxaysa boosaska 4 iyo 8′ ee qaabaynta beta. Procyanidin B2 waxaa laga heli karaa Cinchona pubescens (Chinchona, ee dhogorta, jilif iyo kortex), in Cinnamomum verum (Ceylon qorfe, ee lafaha, jilif iyo kortex), in Crataegus monogyna (Hawthorn caadiga ah, ee ubaxa iyo ubaxa). gudaha Uncaria guianensis (cat's claw, ee xididka), gudaha Vitis vinifera (canabka caadiga ah, caleenta), gudaha Litchi chinensis (litchi, pericarp), tufaaxa, Ecdysanthera utilis iyo khamriga cas. Waxay leedahay door sida dheef-shiid kiimikaad iyo antioxidant. Waa hydroxyflavan, proanthocyanidin, biflavonoids iyo polyphenol. Waxay ka timaadaa (-)-epicatechin.
Budada Procyanidin C1 waa proanthocyanidin ka kooban saddex (-) - epicatechin unugyo ay ku biireen laba isku xigta (4beta-> 8) -links. Waxay leedahay door sida dheef-shiid kiimikaad, wakiilka anti-bararka, antioxidant, lipoxygenase inhibitor, EC 1.17.3.2 (xanthine oxidase) inhibitor iyo EC 3.2.1.20 (alpha-glucosidase) inhibitor. Waa hydroxyflavan, proanthocyanidin iyo polyphenol. Waxay ka timaadaa (-)-epicatechin.
Taariikhda Budada Procyanidin
Budada Procyanidins, oo ay ku jiraan polymers-ka yar ee bioactive / bioavailable (4 ama ka badan catechines), waxay ka dhigan yihiin koox ka mid ah flavan-3-ols oo la shiilay oo laga heli karo dhir badan, gaar ahaan tufaaxa, jilif geedka badda, qorfe, miro aronia, digirta kookaha. , iniinaha canabka, haragga canabka, iyo khamriga cas ee Vitis vinifera (canabka caadiga ah). Si kastaba ha ahaatee, bilberry, karamberriga, currant madow, shaaha cagaaran, shaaha madow, iyo dhirta kale ayaa sidoo kale ku jira flavonoids kuwan.Procyanidins sidoo kale waa laga go'doomin karaa Quercus petraea iyo Q. robur heartwood (wine barrel oaks) Saliida Açaí, laga helay midhaha timirta açaí (Euterpe oleracea), waxay qani ku tahay oligomers badan oo procyanidin ah.
Tufaaxu waxa uu ka kooban yahay celcelis ahaan siddeed jeer xadiga procyanidin ee laga helo khamriga, iyadoo qaar ka mid ah xadiga ugu badan laga helay noocyada Cas Delicious iyo Granny Smith.
Tijaabooyinka abuurka ee digirta beerta (Vicia faba) waxaa ku jira procyanidins kuwaas oo saameeya dheefshiidka doofaarka waxayna yeelan karaan waxqabad ka hortag ah enzymes. Cistus salviifolius waxa kale oo ku jira oligomeric procyanidins.
Procyanidin Powder Mechanism of Action
Proanthocyanidins waxay fududeeyaan cudurada wadnaha iyada oo loo marayo nasashada markabka iyo joojinta oksaydhka LDL. Proanthocyanidins waxay joojin kartaa isku-xidhka LDL oksaydhka ah ee lectin-like oxidized LDL reseptor (lectin-like oxidized LDL reseptor-1 (LOX-1), kaas oo ku lug leh pathogenesis ee arteriosclerosis.
Habka ugu muhiimsan ee ficilka procyanidin B2 waxaa loola jeedaa ficilkeeda kobcinta kobaca ee timaha unugyada epithelial (Takahashi et al., 1999a). Dhaqdhaqaaqa xooggan ee anti-oxidative ee procyanidin B-2 ayaa laga yaabaa inay wax weyn ka tarto saameynteeda. Xidhiidhka ka dhexeeya bidaarta qaabka labka ah iyo caabuqa ayaa waxaa tilmaamay dhowr cilmi-baarayaal. Waxaa la soo wariyay in caabuqa lymphocytic lagu arkay agagaarka timaha follicles biopsied ee bukaanada muujinaya bidaarta qaabka labka ah (Sueki et aI., 1999; Jaworsky et aI., 1992). Yar iyo a1. (1991) ayaa sidoo kale sheegay in saamiga maaddooyinka muujinaya caabuqa madaxa ay ahayd 100 % maadooyinka leh bidaarta qaabka labka ah, halka saamiga uu ahaa 66 % maadooyinka aan bidaarta lahayn. Procyanidins waxaa loo yaqaanaa inay muujiyaan saameynta hoos u dhigista bararka sababtoo ah sifooyinka anti-oxidative (Haslam, 1996) iyo ficilkooda protease joojinta (Tixier et al., 1984). Sidaa darteed, waxaa loo malaynayaa in xakamaynta caabuqa ee uu dhexdhexaadinayo procyanidin B-2 ay dib ugu soo celiso madaxa xaalad caafimaad leh, taas oo horseedaysa daawo bidaarta.
Codsiga budada Procyanidin
Hawlaha Antioxidant
Procyanidin wuxuu leeyahay firfircoonida antioxidant aad u xoog badan, kaas oo u shaqeeya sidii hab ka hortag ah oo ka dhan ah diiqada oksaydhka ee ay keento noocyada ogsijiinta firfircoon (ROS) ee deegaanka. Proanthocyanidins waxay leeyihiin 20 jeer awoodda antioxidant ee fitamiin C iyo 50 jeer awoodda antioxidant ee fitamiin E. Marka laga reebo, procyandin's
firfircoonida antioxidant iyo awoodda xoqista waxay u dhigantaa cabbirkeeda iyo ka kooban yahay. Shaqadeeda antioxidant waxay inta badan la xiriirtaa noocyada ogsijiinta falcelinta (ROS).
Ka-hortagga kansarka iyo Waxqabadka Antitumor
Isku dheelitir la'aanta dib-u-celinta ee jirka waxay keeni kartaa cudur inuu sameeyo. Waxay inta badan la xiriirtaa kororka ama uruurinta cadaadiska oksaydhka. Cadaadiska Oxidative wuxuu keeni karaa isbeddellada DNA-da iyo isbeddellada epigenetic, iyo sidoo kale beddelka borotiinnada chromatin. Xaaladahan waxay sababi doonaan carqalad ku timaada shaqada caadiga ah ee unugyada iyo isbeddelka waddooyinka calaamadaha.
Unugyada kansarku, guud ahaan, waxay leeyihiin dheef-shiid kiimikaad la dedejiyey. Heer sare oo ROS ah ayaa loo baahan yahay si loo ilaaliyo hababka dheef-shiid kiimikaadka, horumarka, iyo fidinta. Joogitaanka heerka sare ee ROS waxay kicin doontaa oo ka sii dari doontaa dheef-shiid kiimikaadkooda, iyo sidoo kale weerar xooggan oo waxyeello u geysta DNA-da, lipids, iyo borotiinada.
Procyanidins ayaa la ogaaday inay saameyn ka hortag ah ku leeyihiin kansarka qanjirka 'prostate' ee heerka sare ah. Daraasadani waxay taageertay natiijooyinka ka soo baxa daahfurka in isku darka procyanidin iyo ka kooban yahay firfircooni ay bartilmaameedsan karaan unugyada asliga ah ee kansarka qanjirka 'prostate'.
Natiijooyinkoodu waxay daaha ka qaadeen in procyanidin iyo ka kooban yahay ay si weyn u yareeyeen habka loo yaqaan 'Notch1 ligand' ee firfircoon ee dariiqa lagu beegsanayo korriinka qanjirka 'prostate' iyo soo noqoshada burada.
Dhaqdhaqaaqa ka hortagga bararka
Dhaqdhaqaaqa ka hortagga bararka Procyanidins ayaa sidoo kale la baaray iyadoo la adeegsanayo noocyo kala duwan. Tusaale ahaan, shucaaca ultraviolet wuxuu keenaa erythema, barar, iyo jawaabaha epithelial hyperplastic, kuwaas oo dhamaantood door muhiim ah ka ciyaara sameynta burooyinka maqaarka. Cilmi-baadhistu waxay ogaatay in
Qaadashada cuntada ee procyanidins waxay saameyn ku yeelataa cyclooxygenase-2 (COX-2) muujinta enzyme, waxay joojisaa bararka shucaaca UV, erythema, faleebo leukocytes bararka, iyo dhaqdhaqaaqa myeloperoxidase ee maqaarka jiirka.
Guryaha difaaca jirka iyo Xasaasiyadda ka hortagga
Procyanidins ayaa sidoo kale lagu muujiyay daraasado badan si ay u leeyihiin difaac difaac iyo xasaasiyad. Cudurada kala duwan, sida lupus erythematosus systemic, uremia, cudurka Behcet, iyo cudurka mindhicirka xanaaqa, ayaa sidoo kale laga yaabaa inay ku lug yeeshaan unugyada iyo waddooyinka
bartilmaameedka procyanidins. Caspases, PERK/NRF2, NADPH oxidase, iyo JNK/MAPK calaamadaynta calaamaduhu waa qayb ka mid ah dariiqa. Natiijo ahaan, saameynta procyanidins ee ka hortagga cudurrada ayaa ah tan ugu macquulsan ee hagaajinta cudurrada difaaca ee kala duwan. Inkastoo
qaar badan oo ku jira vitro iyo caddaynta unugyada ku salaysan ee saamaynta immunomodulatory, daraasadaha qaabka xayawaanka ayaa xaddidan; sidaas darteed caddaynta bukaan-socodka ayaa si degdeg ah loogu baahan yahay ka hor inta aan la siin talooyinka cunto ee la aamini karo ama kabka iyo daawaynta dhammaystirka ah ee ku salaysan procyanidins.
Waxay wanaajisaa qiyaasaha taranka iyo dhalmada
Waxaa la muujiyay in procyanidins ay saameeyaan xuduudaha taranka, korriinka, iyo caafimaadka uurjiifka. Si kastaba ha ahaatee, cilmi-baaris dheeraad ah ayaa si degdeg ah loogu baahan yahay si loo fahmo faa'iidooyinka suurtagalka ah ee caafimaadka, physiology, hababka, iyo isticmaalka kiliinikada ee ku saabsan taranka iyo bacriminta.
Faa'iidooyinka kale ee budada Procyanidin waxaa ka mid ah:
Doorarka Ilaalinta ee Ka-hortagga Cudurrada Daba-dheeraada iyo Xanuunnada dheef-shiid kiimikaadka
Saamaynta Ka-hortagga bakteeriyada ee Procyanidins
Astaamaha ka hortagga fayraska ee Procyanidins
Cilmi baaris ayaa la sameynayaa si loo eego faa'iidooyinka caafimaad ee xeryahooda. Waxaa la og yahay in cuntada leh khudaarta iyo miraha badan ay yareyso halista noocyo badan oo kansar ah. Waxa kale oo ay hoos u dhigtaa khatarta dhibaatooyinka kale ee la xidhiidha da'da.
Procyanidin B2 faa'iidooyinka koritaanka timaha
Waxay u shaqeysaa sida borotiinka kinase C (PKC) inhibitor, molecules-kan ayaa la caddeeyey in ay kiciyaan ( wajiga anagen ) iyo in ay kor u qaadaan koritaanka unugyada epithelial timaha sida (A.KAMIMURA IYO T.TAKAHASHI) ayaa dib u soo bandhigay 2001. Heerka waxtarka ee 1 % procyanidin B-2 waxaa lagu soo gabagabeeyay in si wanaagsan loo barbardhigo minoxidil iyo daawaynta finasteride. Kooxda procyanidin B-2, kororka tirada guud ee timaha ee aagga loo qoondeeyay (0.5 em square = 0.25 cml) ka dib tijaabada e-bisha waxay ahayd 6.68 ± 5.5 3 (macnaha ± SD) / 0.25 cm2, halka Kooxda xakamaynta placebo, kororka tirada wadarta timaha s waxay ahayd 0.0 8 ± 4.56 (macnaha ± SD) / 0.25 cm2 (Shaxda 2). Waxaa lagu xisaabiyaa th marka la kordhiyo tirada wadarta guud ee timaha ee aagga loo qoondeeyay ee maadooyinka kooxda procyanidin B-2 ka dib markii tijaabada 6-bilood ay aad uga weyn tahay maadooyinka kooxda kontoroolka placebo.
Procyanidin C1 faa'iidooyinka gabowga ka hortagga
Cilmi baaris ayaa lagu ogaaday procyanidin C1 (PCC1), oo ah qayb ka mid ah polyphenolic, ayaa door muhiim ah ka ciyaarta dhexdhexaadinta saameynta gabowga ee GSE. PCC1 waxay xannibtaa odhaahda SASP marka loo isticmaalo xaddi hoose. Muhiimad ahaan, waxay si xushmad leh u dishaa unugyada dareenka marka la codsado heerar sare, badiyaa iyadoo kor u qaadeysa soosaarka noocyada ogsijiinta falcelinta (ROS) iyo khalkhalgelinta awoodda xuubka mitochondrial, hababka ay weheliso kor u qaadista arrimaha qoyska Bcl-2 ee pro-apoptotic Puma iyo Noxa ee unugyada dareenka. PCC1 waxay baabi'isaa unugyada dareenka ee buro microenvironment-damageded (TME) waxayna xoojisaa waxtarka daweynta marka lagu daro kiimoterabiga ee qiimaynta hore. Maamulka joogtada ah ee PCC1 ee jiirarka unugyada lagu beeray iyo xayawaanka dabiiciga ah ee da'da ah waxay yareeyeen hawlgabka jireed iyo badbaadada daawaynta daba dheeraatay, sidaas darteed waxay siisay faa'iidooyin la taaban karo marxaladda nolosha dambe. Si wada jir ah, daraasaddeenu waxay u aqoonsanaysaa PCC1 inay tahay wakiil dabiici ah oo kala duwan, kaas oo laga yaabo in looga faa'iidaysto si loo daahiyo da'da loona xakameeyo cudurrada da'da la xiriira ee dawada mustaqbalka.
Procyanidin Powder Cilmi baaris dheeraad ah
Ilaha cuntada ee proanthocyanidins waxaa ka mid ah:
Canab cas
Canabka madow
Abuurka canabka
khamri Red
Bilberry
Cranberries
strawberries
blåbær
Kaabashka cas
Diirka tufaaxa
Xayawaanka geed
Caleenta baadiyaha bilberry
Birch
Ginkgo biloba
Qiyaasta budada Procyanidin
Ma jiro qiyaas go'an oo loogu talagalay proanthocyanidins.
Dadka uurka leh ama naaska nuujinaya waa inay la hadlaan bixiyaashooda daryeelka caafimaadka ka hor intaysan qaadan wax kaabis ah.
Tixraaca budada Procyanidin
- Vernhet, A.; Dubascoux, SP; Cabane, B.; Fulcrand, HLN; Dubreucq, E.; Poncet-Legrand, CL (2011). "Astaamaynta tannins oksaydhka: Isbarbardhigga hababka depolymerization, jajabinta qulqulka qulqulka qulqulka iyo xagasha yar ee raajada". Analytical and Bioanalytical Chemistry. 401 (5): 1559-1569.
- Jorgensen, Emily M.; Mariin, Anna B.; Kennedy, James A. (2004). "Falanqaynta Hoosudhaca Oxidative ee Proanthocyanidins ee hoos yimaada Shuruudaha aasaasiga ah". Joornaalka Kiimikada Beeraha iyo Cuntada. 52 (8): 2292-2296. doi:10.1021/jf035311i. PMID 15080635.
- Griffiths, DW (1981). "Waxa ku jira polyphenolic iyo waxqabadka xannibaadda enzyme ee testas laga bilaabo bean (Vicia faba) iyo digir (Pisum spp.) noocyo". Joornaalka Sayniska Cuntada iyo Beeraha. 32 (8): 797-804. doi:10.1002/jsfa.2740320808.
- Thompson RS, Jacques D., Haslam E. iyo Tanner RJN (1972) Plant proanthocyanidins. Qaybta I. Hordhac; Go'doominta, qaab-dhismeedka iyo qaybinta dabiiciga ah ee procyanidins dhirta. Wargeyska Ururka Kiimikada. Perkin Transactions 1, Organic and Bio-organic Chemistry , 1387±1399.
