Products
Budada Anandamide (AEA) (94421-68-8)
Anandamide (AEA) budada (94421-68-8) fiidiyaha
Macluumaadka Salka Anandamide (AEA)
| magaca | Budada Anandamide (AEA) |
| CAS | 94421-68-8 |
| xagiisayna | 98% |
| Magaca kiimikada | N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
| Isku mid ahaanshaha | Arachidonoyl Ethanolamide, AEA, arachidonoylethanolamide, (5Z, 8Z, 11Z, 14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine |
| Formula kelli | C22H37NO2 |
| Miisaanka kelli | 347.53 |
| Dhibicda Biyaha | / |
| Muhiimadda InChI | LGEQQWMQCRIYKG-DOFZRALJSA-N |
| Form | saliidda |
| Imaanshaha | iftiin huruud ah |
| Nolosha badh | / |
| milmi | Ku milma DMSO (~ 30 mg / ml), DMF (~ 10 mg / ml), ethanol anhydrous (5 mg / ml), PBS, pH 7.2 (~ 100 mg / ml), iyo biyo (<0.1 mg / ml at 25 ° C). |
| kaydinta Xaaladda | 80 ° C (des.) |
| Codsiga | Qalabka daroogada cannabinoid endogenous ligand |
| Dukumentiga Tijaabinta | Available |
Anandamide (AEA) Tilmaanta Guud
Anandamide, oo sidoo kale loo yaqaan N-arachidonoylethanolamine (AEA), waa neurotransmitter dufan leh oo laga soo qaatay dheef-shiid kiimikaad la'aan ah eicosatetraenoic acid (arachidonic acid), waa lagama maarmaan omega-6 fatty acid. Magaca waxaa laga soo qaatay erayga Sanskrit ee ananda, oo macnaheedu yahay "farxad, raynrayn, raynrayn", iyo amide. Waxaa laga soosaaray N-arachidonoyl phosphatidylethanolamine wadooyin badan.
Hal-abuurka ka sokow, anandamide wuxuu leeyahay faa'iidooyin badan sidoo kale, halkan waa sharaxaad guud oo ku saabsan iyaga.
Xusuusta Shaqeynta - Tani waa mid ka mid ah qaybaha ugu muhiimsan ee hal abuurka. Sidaan kor ku soo sheegnay, anandamide waxay ka caawineysaa aruurinta macluumaad fara badan si loo abuuro fikrado cusub. Waxaa jira daraasado yar oo laga sameeyay dadka waaweyn ee caafimaadka qaba, laakiin hal muunad ayaa muujisay in jiirku ku dhibaateysan yaraanta xusuusta shaqadu ay kor u qaadday cabbirka garashada oo keliya anandamide.
Markhaati tan, waxaa cad in anandamide la macaamilayso xusuusta shaqada iyo habab kala duwan. Isbeddelka ayaa cilmi ahaan la xaqiijiyay, laakiin dadka waaweyn ee caafimaadka qaba baaxadda wali lama oga.
Neurogenesis - Sida laga soo xigtay Dr. Gary Wenk, anandamide wuxuu noqon karaa kiimikal awood leh oo la xidhiidha neurogenesis gaar ahaan waayeelka. Maadama cilmi baadhe u ah neerfayaasha, wuxuu leeyahay aragtiyo ku saabsan saamaynta anandamide iyo is-dhexgalka maskaxda.
Illaa dhowaan, saynisyahano waxay rumeysan yihiin in neurogenesis (sii kordheysa unugyada maskaxda ee cusub) ay ku dhacday kaliya dhalinyarada iyo dhalinyarada. Maanta si fiican ayaa loo ogyahay in neurogenesis uu sii dheeraado ilaa qaangaarnimada isla markaana sida ugu wanaagsan aan u maareyn karno, khatarta yar ee aan ku haysanno dhibaatooyinka neurodegenerative sida arrimaha xusuusta iyo waallida.
Ka-hortagga Murugada - Wixii ka baxsan faa'iidooyinka garashada, waxaa jira dhowr niyadda iyo tayada nolosha kor u qaadista anandamide sidoo kale. Daraasadaha lagu sameeyay moodhalka maskaxda jiirka ayaa soo jeedinaya in anandamide ay leedahay saameyn adag oo ka hortagga niyad-jabka ah ee maskaxda ku jirta, taas oo caawin karta kuwa qaba niyad-xumo.
Budada Anandamide (AEA) budada (94421-68-8) Taariikh
Anandamide waxaa markii ugu horreysay la sharxay (lana magacaabay) 1992 waxaa qoray Raphael Mechoulam iyo xubnahiisa sheybaarka WA Devane iyo Lumír Hanuš.
Codsiga budada Anandamide (AEA)
Anandamide waxaa loo habeeyay enzymatically aagagga maskaxda ee muhiimka u ah xusuusta, hababka fikirka iyo xakameynta dhaqdhaqaaqa. Cilmi baaris ayaa soo jeedisay in anandamide door ka cayaarto sameynta iyo jabinta xiriirada muddada-gaaban ee u dhexeeya unugyada dareemeyaasha, tanina waxay la xiriirtaa barashada iyo xusuusta. Daraasadaha xayawaanku waxay muujinayaan in aad u badan oo anandamide ah ay keento iloobin. Tani waxay soo jeedineysaa haddii walxaha la soo saari karo ee ka hortagaya in anandamide ay ku xirnaadaan qabtaheedii, kuwan waxaa loo isticmaali karaa in lagu daaweeyo luminta xusuusta ama xitaa si kor loogu qaado xusuusta hore!
Anandamide (AEA) Baadhis dheeraad ah
Basbaaska madow waxaa ku jira guineynin alkaloid ah, oo ah anandamide reuptake inhibitor. Sidaa darteed way kordhin kartaa saamaynta jir ahaaneed ee anandamide.
Qaadashada qaadashada yar ee anandamide waxay leedahay saameyn anxiolytic ah, laakiin qaadashada qaadashada badan ee jiirka ayaa muujineysa dhimashada hippocampus oo muuqata.
Haweeney u dhalatay Scotland oo dhif ku ah hidde-wadeyaasha hidde ah ee 'FAAH' oo leh natiijooyin aad u sarreeya oo heerka anandamide ah ayaa la soo sheegay inay ka badbaado walwalka, oo aan awoodin inay la kulanto cabsi iyo feejignaan xanuun. Gubashooyinka iyo goynta joogtada ah ee ay la kulanto dhiig-baxa 'hypoalgesia' way ka bogsatay si ka dhakhso badan celcelis ahaan.
Budada Anandamide (AEA) budada (94421-68-8) Tixraac
- Devane, W .; Hanus, L; Breuer, A; Pertwee, R .; Stevenson, L.; Griffin, G; Gibson, D; Mandelbaum, A; Etinger, A; Mechoulam, R (18 Diseembar 1992). "Gooni ahaanta iyo qaabdhismeedka maskaxda qayb ka mid ah oo ku xidhan qaataha Cannabinoid". Sayniska. 258 (5090): 1946–
- Mechoulam R, Fride E (1995). “Wadada aan la furin ee ku socota maskaxda xididdada cannabinoid, anandamides”. In Pertwee RG (ed.). Daawooyinka Cannabinoid. Boston: Saxaafadda Tacliinta. bogga 233–
- Battista, N., iyo Maccarrone, M. (2017). “Farsamooyinka aasaaska ah ee isku-darka iyo biyo-u-helista endocannabinoids,” ee Nidaamka Endocannabinoid: Waxyaalaha guud, cilmiga biokem, cilladaha maskaxda, iyo daaweynta, ed. E. Murillo-Rodriguez (Amsterdam: Elsevier), 1 24.
- Devane et al. (1992), Go'doon iyo qaab dhismeedka maskaxda qayb ka mid ah oo ku xidhan qaata Cannabinoid; Saynis, 258 1946.
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Anandamide (AEA): Waxkastoo Aad U Baahan Tahay Inaad Ka Ogaato
