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Cycloastragenol (CAG) budada 78574-94-4

Budada Cycloastragenol waa moleekule gooni looga soocay noocyo kala duwan oo kujira hiddo-wadaha Astragalus ee loo maleynayo inuu leeyahay dhaqdhaqaaqa firfircoonaanta telomerase. Hal daraasad ku jirta 'vitro' oo la sameeyay sanadkii 2009 ayaa keentay sheegashooyinka ah in cycloastragenol laga yaabo inuu dhaqaajiyo telomerase, taasoo horseedaysa sheegashooyinka is khilaafsan ee doorka ay ku leeyihiin yaraynta saamaynta da'da.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Cycloastragenol (CAG) budada (78574-94-4) fiidiyoow

 

 

Cycloastragenol (CAG) budada Macluumaadka Saldhigga

magaca Cycloastragenol (CAG) budada
CAS 78574-94-4
xagiisayna 50% , 98%
Magaca kiimikada CYCLOASTRAGENOL
Isku mid ahaanshaha Cyclosieversigenin; Cyclosiversigenin; Astramembrangenin; (3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;
Formula kelli C30H50O5
Miisaanka kelli 490.72
Dhibicda Biyaha 241-245 ° C
Muhiimadda InChI WENNXORDXYGDTP-UOUCMYEWSA-N
Form Solid
Imaanshaha budo White
Nolosha badh /
milmi Dhibaatada Methanol, Ethanol
kaydinta Xaaladda 4 Qaboojiyaha, shaabadaysan, madow
Codsiga Cycloastragenol waa firfircoon awood telomerase ah. Sidoo kale, waxay kuxirantahay la-dagaallanka gabowga daawo-dhaqameedka Shiinaha.
Dukumentiga Tijaabinta Available

 

Cycloastragenol (CAG) budada Sharaxaada Guud

Budada Cycloastragenol waxay leedahay qaab dhismeed kiimiko oo la mid ah tan molecule Astragaloside IV, laakiin way ka yar tahay uguna weyn tahay bioavirka la heli karo, taasoo u saamaxaysa qaadashooyinka hoose in la qaato. Horaa loo isticmaalaa sidii immunostimulant sababta oo ah awooda uu u leeyahay inuu kordhiyo faafitaanka T lymphocyte. Si kastaba ha noqotee, waa dhismaheeda gaarka ah ee kahortagga gabowga ee danta u leh bulshada cilmiga ah.

Budada 'Cycloastragenol' waxay kicisaa hagaajinta dhaawaca DNA iyada oo dhaqaajineysa telomerase, Nucleoprotein enzyme kaas oo kiciya isku-darka iyo koritaanka telomeric DNA. Telomeres waxaa laga sameeyaa fiilooyin khafiif ah waxaana laga helaa talooyinka koromosoomyada. Joogtaynta xasilloonidoodu waxay u suurtogelisaa unugyada inay ka fogaadaan jiritaanka sumcadda iyo kordhinta aan xadidnayn ee ka baxsan 'xadka Hayflick'. Telomeres waxay gaabinaysaa wareeg kasta oo unug unug ah, ama markay ku dhacdo diiqadda oksidheer. Illaa iyo hadda, tani waxay ahayd farsamo aan laga maarmin oo gabow ah.

 

Cycloastragenol (CAG) budada (78574-94-4) Taariikhda

Budada Cycloastragenol waxaa markii uguhoreysay lagu iibiyay kaabayaasha cuntada ee gudaha USA 2007 iyadoo la adeegsanayo magaca TA-65, tani waa sababta TA 65 ama TA65 ay wali tahay magaca ugu caansan cycloastragenol. CAS 84605-18-5 iyo CAS 78574-94-4 ayaa ah aqoonsiga joogtada ah ee xirfadlayaasha iibsada alaabta ceeriin iyo cilmi baarayaasha.

Cycloastragenol waa triterpene aglycone oo ah nooca 9,19-cyclolanostane-ka soo baxay oo laga nadiifiyey asalka geedka Astragalus membranaceus, kaas oo loo adeegsaday dawooyinka dhaqanka ee Shiinaha muddo ka badan laba kun oo sano, gaar ahaan awoodda ay u leedahay inuu hoos u dhigo da'da la xiriirta da'da. geeddi-socodka deg-degga ah. Triterpene glycosides waxay ka tirsan tahay heerka metabolites warshad sare ee loo yaqaan saponins waxayna ka kooban tahay polycyclic aglycone kuna lifaaqan C3 iyo isku xirnaanta isku xidhka silsiladda dhinaca sonkorta. 

 

Cycloastragenol (CAG) budada Mechanism Of Action

Baarayaasha waxay ogaadeen in Cycloastragenol uu aad ugu fiicanyahay dib udhaca nidaamka howsha isagoo kordhinaya dhererka telomereska, kaas oo lama huraan u ah inuu gaabiyo gabowga. Tan waxaa lagu dhammeeyaa iyada oo la kicinayo ficil falgal enzyme loo yaqaan telomerase kaas oo dayactira telomereska jaban / jaban. Ilaa hadda cycloastragenol ayaa noqon kara firfircoonida telomerase oo keliya iyadoo la kordhinayo tirada telomerase.

Cycloastragenol wuxuu fidiyaa unugyada T ee unugyada iyadoo la kordhinayo waxqabadka telomerase taas oo ka caawin doonta unugyo badan inay kor u qaadaan telomereskooda muddo dheer, iyagoo ku daray sanado badan oo suurtagal ah taranka unugyada oo qaarkood ay rumeysnaan karaan inay cimri dheerayn doonaan nolosha aadanaha.

 

Cycloastragenol (CAG) budada (78574-94-4) Codsiga

  1. Lagu dabaqo maaddada waxsoosaarka caafimaadka, cycloastreganol 50% iyo 98% budada waxaa loo isticmaali karaa sida waxyaabaha cuntada lagu daro;
  2. Waxaa lagu dabaqay maaddada dawooyinka, 98% budada cycloastragenol waa la isticmaali karaa, marka loo eego daraasadda rugta caafimaadka ee sayniska adag.

 

Cycloastragenol (CAG) (78574-94-4) Cilmi baaris dheeraad ah

Waxqabadka budada Cycloastragenol

1.Astragalus Extract Cycloastragenol waxay kordhin kartaa tamarta iyo adkaysiga, waxay kor u qaadeysaa nidaamka difaaca iyo caawinta ka soo kabashada walaaca joogtada ah ama jirada dheer.

2.Warbixinnada ayaa caddeeyay in Astragalus Extract Cycloastragenol ay kor u qaaddo waxqabadka dhowr nooc oo unugyada dhiigga cad ah isla markaana ay kordhiso soo saarista unugyada ka hortagga fayraska iyo 'interferon', jirka oo leh wakiilka ka hortagga fayraska dabiiciga ah.

3.Cycloastragenol waxay saamayn ku leedahay yaraynta walbahaarka iyo ka ilaalinta jirka walwalka kala duwan,oo ay ku jiraan culayska jirka, maskaxda, ama dareenka;

4.Astragalus Extract waxay leedahay howsha kor u qaadista xasaanada, jirka ka difaacida cudurada sida kansarka iyo sokorowga;

5.waxaa ku jira antioxidants, kuwaas oo ka ilaaliya unugyada waxyeelada ay keenaan xagjirrada xorta ah;

6.waxaa loo adeegsadaa ilaalinta iyo taageer nidaamka difaaca, bakteeriyada, iyo bararka bararka, si looga hortago hargabka iyo caabuqyada neef -mareenka sare;

7.Cycloastragenol waxay saamayn ku leedahay hoos u dhigidda cadaadiska dhiigga, daaweynta sonkorowga iyo ilaalinta beerka.

 

Cycloastragenol (CAG) budada (78574-94-4) Tixraaca

  • Ma, P., iyo al.: Xenobiotica, 47, 526-537 (2017); Shen, C., iyo al.: Br. J. Pharmacol., 174, 1395-1425 (2017)
  • Le Saux CJ, Davy P, Brampton C, et al. Dhaqdhaqaaqaha telomerase cusub ayaa xakameynaya waxyeelada sambabka qaab muusiko ah oo loo yaqaan 'idiopathic pulmonary fibrosis'. PLoS Mid. 2013; 8 (3): e58423. PMID: 23516479.
  • Caliş I, Koyunoğlu S, Yeşilada A, et al. Antitrypanosomal cycloartane glycosides oo ka timid Astragalus baibutensis. Chem Biodivers. 2006 Agoosto; 3 (8): 923-9.
  • Cycloastragenol (CAG): Faa'iidooyinka, Qiyaasta, Dhibaatooyinka Dhinacyada

 

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