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Budada PQQ (72909-34-3)

Pyrroloquinoline quinone (PQQ) budada, coenzyme oo ka kooban fitamiin la mid ah nafaqada la xiriirta qoyska B-fiitamiinada, waxay leedahay magacyo badan oo caan ah, sida methoxatin, BioPQQ, iwm PQQ ayaa si dabiici ah looga helaa inta badan cuntada dhirta, miraha, khudradda (miniscule) cadad) iyo heerar sare oo qaraabo ah ayaa lagu ogaan karaa waxyaabaha soywaatka leh ee sida soybeanska cagaaran, isbinaajka, ubaxyada kufsiga, basbaaska cagaaran, miraha Kiwi, iwm.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Quwadoneyaasha Pyrroloquinoline video budada

 

Budada Quinone Pyrroloquinoline (72909-34-3) Macluumaadka Saldhigga

 

magaca Quwadoneyaasha Pyrroloquinoline
CAS 72909-34-3
xagiisayna > 98%
Magaca kiimikada 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
Isku mid ahaanshaha Coenzyme PQQ

Coenzyme, PQQ

Isku-duwaha, PQQ

Methoxatin

PQQ Coenzyme

Formula kelli C14H6N2O8
Miisaanka kelli 330.208 g / mol
Dhibicda Biyaha 200 ° C
Muhiimadda InChI MMXZSJMASHPLLR-UHFFFAOYSA-N
Form A adag crystalline
Imaanshaha budada casaanka
Nolosha badh 3-5 h
milmi Dhibaatada Methanol iyo Biyaha
kaydinta Xaaladda -20 ° C
Codsiga Redox / cofactor waxaa laga helaa fasalka ugu horeeya ee enzymes-ka loo yaqaan quinoproteins

kaabeyaasha cuntada, waxyaabaha cuntada lagu daro, daawooyinka, dawooyinka

Dukumentiga Tijaabinta Available

 

Pyrroloquinoline quinone (PQQ) budada Sharaxaada Guud

Pyrroloquinoline quinonePQQ) budada, oo sidoo kale loo yaqaanno methoxatin, waa isku -duwaha redox. Waxaa laga helaa carrada iyo cuntooyinka sida kiwifruit, iyo sidoo kale caanaha naaska ee dadka. Enzymes -ka ay ku jiraan budada quinone Pyrroloquinoline waxaa lagu magacaabaa quinoproteins. Glucose dehydrogenase, oo ka mid ah quinoproteins, ayaa loo isticmaalaa dareeme gulukoos. Budada quinone ee Pyrroloquinoline waxay kicisaa koritaanka bakteeriyada.

Pyrroloquinoline budada quinone waxaa loo helay inay horumariso ma aha oo kaliya xusuusta degdegga ah, laakiin sidoo kale shaqooyinka kale ee maskaxda ee sarreeya sida wacyiga xayawaanka. Saamaynta budada Quinone ee Pyrroloquinoline ayaa la wanaajiyey markii walaxda loo isticmaalay CoQ10. Faa'iidooyinka ugu muhiimsan ee budada qufulone ee Pyrroloquinoline waxaa ka mid ah caafimaadka mitochondrial, taageerada maskaxda, iyo caafimaadka wadnaha.

 

Pyrroloquinoline quinone (PQQ) budada Taariikhda

Pyrroloquinoline budada quinone waxaa lagu ogaadey JG Hauge inuu yahay cofactor saddexaad ee redox ka dib nicotinamide iyo flavin ee bakteeriyada (in kasta oo uu u maleeyay inay ahayd naphthoquinone). Anthony iyo Zatman ayaa sidoo kale helay cofactor redox-ka aan la aqoon ee kujira aalkolka dehydrogenase. Sanadkii 1979, Salisbury iyo asxaabtiisii ​​iyo sidoo kale Duine iyo asxaabteedu waxay ka soo saarteen kooxdan qanjirka 'methanol dehydrogenase ee methylotrophs waxayna aqoonsadeen qaab dhismeedka molikalikada. Adachi iyo asxaabtiisuba waxay ogaadeen in Querone Pyrroloquinoline sidoo kale laga helay Acetobacter.

 

Pyrroloquinoline quinone (PQQ) budada Mechanism Of Action

Sidee buu pyrroloquinoline quinone u shaqeeyaa? Daraasaduhu waxay soo jeedinayaan budada quinone ee Pyrroloquinoline waxay taageertaa qaabdhismeedka mitokondrial caafimaad leh iyo shaqo si ay gacan uga geysato sii wadida hawlaha maskaxda ee caafimaad qaba sida xusuusinta, xusuusta iyo garashada markaan sii gabowno.

Daraasad ayaa muujisay budada Quinone ee Pyrroloquinoline:

  • Wuxuu saameeyaa wadiiqooyinka calaamadaha unugyada ee ku lug leh koritaanka unugyada, kala duwanaanshaha iyo badbaadada
  • Waxay ka ilaalisaa cudurka mitochondria ee jira waxyeelada
  • Waxay kaa caawineysaa abuurista mitochondria cusub
  • Ka ilaali unugyada dareemayaasha

Faa'iidooyinka qaadashada budada Quinone Pyrroloquinoline waxay ka timaadaa habab kala duwan, oo dhammaantood ku lug leh borotiinka unugyada. Marka hore, PQQ wuxuu hawl galaa receptor ku yaal nudaha unugyada loo yaqaanNR1C3. Soo-dhoweyntan Nukliyeerka ayaa mas'uul ka ah isu-duwidda guud, oo ay ku jiraan koritaanka unugyada iyo neefsashada mitochondrial.

Si lamid ah ficillada kaydka CILTEP, Pyrroloquinoline budada quinone waxay dhaqdhaqaaqdaa borotiinka 'CREB' oo tilmaamaya borotokoolka, kaas oo si toos ah u horseeda koritaanka mitochondria cusub wuxuuna dhiiri galiyaa abuurida isku xirnaanta dareemayaasha cusub, xaalada maskaxda. Intaa waxaa sii dheer, budada Quinone Pyrroloquinoline waxay la falgashaa dhowr moleekuleyaal ah oo tilmaamaya gudaha kuwaas oo ka caawiya kahortaga walaaca sunta. Tani waxay si gaar ah muhiim ugu tahay unugyada maskaxda, kuwaas oo u isticmaala tamar aad u sareeya isla markaana soo saarta istiraatiijiyado badan oo lacag la’aan ah natiijada.

 

Pyrroloquinoline quinone (PQQ) budada Codsiga

  • Sida antioxidant awood leh, Pyrroloquinoline quinone ayaa difaacda waxayna kordhisaa shaqeynta jirada mitochondria

-Dhinaca gabowga mitochondrial.

  • Pyrroloquinoline quinone powderalso wuxuu kobciyaa jiilka cusub ee mitochondria (Mitochondrial Biogenesis).

-Waxaa soo kordhay mitochondria = soosaarka tamarta.

  • PQQ waxay kicineysaa soosaarka Xaqiiqda Kobcinta dareemeyaasha (NGF).

-NGF waxay kicisaa koritaanka unugyada dareemeyaasha si ay u dayactiraan dareemayaasha waxyeelada ka soo gaara istaroogga ama dhaawaca kale.

 

Pyrroloquinoline quinone (PQQ) budada cilmi baaris dheeraad ah

Dhiigxinjirow Ischemic

Budada Pyrroloquinoline quinone sidoo kale waxay door muhiim ah ka ciyaari kartaa ka ilaalinta maskaxda maskaxda burburka istaroogga.

Istaroog ischemic wuxuu dhacaa marka luminta bixinta dhiigga ee meel gaar ah oo maskaxda ah ay ka qaado maskaxda maskaxda nafaqooyinka / ogsajiinta muhiimka ah ee ay u baahan tahay. Natiijaduna waa dhimashada unugyada maskaxda iyo hawl luminta oo ka turjumaysa gobolka maskaxda halka uu waxyeelladu ka soo gaadhay. Iyada oo ku xidhan aagga ay dhibaatadu saameysey, tan waxay ku dambayn kartaa curyaannimo, xusuusta oo yaraata, iyo xitaa geeri.

Daraasadaha shaybaarka, Pyrroloquinoline quinone budada ayaa hoos u dhigtay dhaawaca ischemic, taasoo suurtagal ka dhigeysa hagaajinta tayada nolosha kadib istaroog.

Tan waxaa si cad loogu muujiyey nooc xayawaan ah oo dhiig-baxa maskaxda ku dhaca. Markii PQQ dheeraadka ah lasiiyay kahor ischemia kahor intaan laqalin, waxay si weyn hoos udhacday cabirka unugyada dhaawaca maskaxda. Waxaa la yaab leh, PQQ waxay leedahay saameyn difaac la mid ah xitaa markii la maamulay ka dib markii ischemia la dagaallamay.26

Daraasad kale ayaa muujisay saameyn la mid ah dareemayaasha. Waxay sidoo kale muujisay in PQQ ay horseedday inay si weyn u horumariso dhibcaha neurobehavioral ka dib istaroogga.27 Natiijooyinkaas ayaa aad ugu farxay kuwa ka shaqeeya aagga ka hortagga iyo daweynta istaroogga aadanaha. Ujeeddada ayaa ah in bukaannada madax-dhiigfuranka lagu siin karo PQQ qolka gargaarka degdegga ah isla markaana ay yarayn karaan curyaaminta maskaxda.

 

Tixraaca

  • Kim, J., Kobayashi, M., Fukuda, M., et al. Quinone-ka Pyrroloquinoline wuxuu xannibayaa fibrillation-ka borotiinka amyloid-ka ah Prion 4 (1), 26-31 (2010).
  • Guan, S., Xu, J., Guo, Y., et al. Quinta loo yaqaan 'Pyrroloquinoline quinone' oo looga soo horjeedo glutamate-inagu-neurotoxicity-ga ee kujirta jirridda neerfaha iyo unugyada progenitor Int. J. Dev. Neurosci. 42, 37-45 (2015).
  • Rucker R, Chowanadisai W, Nakano M. Muhiimadda jir ahaaneed ee pungroloquinoline quinone. Beddelka Med Rev. 2009; 14 (3): 268-77.
  • Klinman JP, Bonnot F. Qeexdinta iyo iswaafajinta dariiqyada biosynthetic for enzymatic quinocofactors: PQQ, TTQ, CTQ, TPQ, iyo LTQ. Chem Rev. 2014; 114 (8): 4343-65.
  • 5-ta Faa'iidadood ee Qaadashada Quful-tuurka Pyrroloquinoline (PQQ).

 

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