Budada PQQ (72909-34-3)

Quwadoneyaasha Pyrroloquinoline video budada

Budada Quinone Pyrroloquinoline (72909-34-3) Macluumaadka Saldhigga

Pyrroloquinoline quinone (PQQ) budada Sharaxaada Guud

Pyrroloquinoline quinonePQQ) budada, oo sidoo kale loo yaqaanno methoxatin, waa isku -duwaha redox. Waxaa laga helaa carrada iyo cuntooyinka sida kiwifruit, iyo sidoo kale caanaha naaska ee dadka. Enzymes -ka ay ku jiraan budada quinone Pyrroloquinoline waxaa lagu magacaabaa quinoproteins. Glucose dehydrogenase, oo ka mid ah quinoproteins, ayaa loo isticmaalaa dareeme gulukoos. Budada quinone ee Pyrroloquinoline waxay kicisaa koritaanka bakteeriyada.

Budada quinone ee Pyrroloquinoline ayaa la ogaaday in ay wanaajiso oo kaliya xusuusta degdega ah, laakiin sidoo kale hawlaha kale ee maskaxda ee sare sida wacyigelinta goobta. Saamaynta Pyrroloquinoline quinone budada ayaa la wanaajiyay markii walaxda loo adeegsaday CoQ10. Faa'iidooyinka muhiimka ah ee budada quinone ee Pyrroloquinoline waxaa ka mid ah caafimaadka mitochondrial, taageerada maskaxda, iyo caafimaadka wadnaha iyo xididdada dhiigga.

Pyrroloquinoline quinone (PQQ) budada Taariikhda

Pyrroloquinoline budada quinone waxaa lagu ogaadey JG Hauge inuu yahay cofactor saddexaad ee redox ka dib nicotinamide iyo flavin ee bakteeriyada (in kasta oo uu u maleeyay inay ahayd naphthoquinone). Anthony iyo Zatman ayaa sidoo kale helay cofactor redox-ka aan la aqoon ee kujira aalkolka dehydrogenase. Sanadkii 1979, Salisbury iyo asxaabtiisii ​​iyo sidoo kale Duine iyo asxaabteedu waxay ka soo saarteen kooxdan qanjirka 'methanol dehydrogenase ee methylotrophs waxayna aqoonsadeen qaab dhismeedka molikalikada. Adachi iyo asxaabtiisuba waxay ogaadeen in Querone Pyrroloquinoline sidoo kale laga helay Acetobacter.

Pyrroloquinoline quinone (PQQ) budada Mechanism Of Action

Sidee buu pyrroloquinoline quinone u shaqeeyaa? Daraasaduhu waxay soo jeedinayaan budada quinone ee Pyrroloquinoline waxay taageertaa qaabdhismeedka mitokondrial caafimaad leh iyo shaqo si ay gacan uga geysato sii wadida hawlaha maskaxda ee caafimaad qaba sida xusuusinta, xusuusta iyo garashada markaan sii gabowno.

Daraasad ayaa muujisay budada Quinone ee Pyrroloquinoline:

• Wuxuu saameeyaa wadiiqooyinka calaamadaha unugyada ee ku lug leh koritaanka unugyada, kala duwanaanshaha iyo badbaadada
• Waxay ka ilaalisaa cudurka mitochondria ee jira waxyeelada
• Waxay kaa caawineysaa abuurista mitochondria cusub
• Ka ilaali unugyada dareemayaasha

The faa'iidooyinka qaadashada budada Pyrroloquinoline quinone Waxay ka yimaadaan dhowr habab oo kala duwan, kuwaas oo dhamaantood ku lug leh borotiinnada gacanta. Marka hore, PQQ waxay hawlgelisaa reseptor ku yaal xudunta unugyada ee loo yaqaan NR1C3. Soo-dhoweeyahan nukliyeerka ah ayaa mas'uul ka ah abaabulka guud, oo ay ku jiraan koritaanka unugyada iyo neefsiga mitochondrial.

Si lamid ah ficillada kaydka CILTEP, Pyrroloquinoline budada quinone waxay dhaqdhaqaaqdaa borotiinka 'CREB' oo tilmaamaya borotokoolka, kaas oo si toos ah u horseeda koritaanka mitochondria cusub wuxuuna dhiiri galiyaa abuurida isku xirnaanta dareemayaasha cusub, xaalada maskaxda. Intaa waxaa sii dheer, budada Quinone Pyrroloquinoline waxay la falgashaa dhowr moleekuleyaal ah oo tilmaamaya gudaha kuwaas oo ka caawiya kahortaga walaaca sunta. Tani waxay si gaar ah muhiim ugu tahay unugyada maskaxda, kuwaas oo u isticmaala tamar aad u sareeya isla markaana soo saarta istiraatiijiyado badan oo lacag la’aan ah natiijada.

Pyrroloquinoline quinone (PQQ) budada Codsiga

• Sida antioxidant awood leh, Pyrroloquinoline quinone ayaa difaacda waxayna kordhisaa shaqeynta jirada mitochondria

-Dhinaca gabowga mitochondrial.

• Pyrroloquinoline quinone powderalso wuxuu kobciyaa jiilka cusub ee mitochondria (Mitochondrial Biogenesis).

-Waxaa soo kordhay mitochondria = soosaarka tamarta.

• PQQ waxay kicineysaa soosaarka Xaqiiqda Kobcinta dareemeyaasha (NGF).

-NGF waxay kicisaa koritaanka unugyada dareemeyaasha si ay u dayactiraan dareemayaasha waxyeelada ka soo gaara istaroogga ama dhaawaca kale.

Pyrroloquinoline quinone (PQQ) budada cilmi baaris dheeraad ah

Dhiigxinjirow Ischemic

Budada Pyrroloquinoline quinone sidoo kale waxay door muhiim ah ka ciyaari kartaa ka ilaalinta maskaxda maskaxda burburka istaroogga.

Istaroog ischemic wuxuu dhacaa marka luminta bixinta dhiigga ee meel gaar ah oo maskaxda ah ay ka qaado maskaxda maskaxda nafaqooyinka / ogsajiinta muhiimka ah ee ay u baahan tahay. Natiijaduna waa dhimashada unugyada maskaxda iyo hawl luminta oo ka turjumaysa gobolka maskaxda halka uu waxyeelladu ka soo gaadhay. Iyada oo ku xidhan aagga ay dhibaatadu saameysey, tan waxay ku dambayn kartaa curyaannimo, xusuusta oo yaraata, iyo xitaa geeri.

Daraasadaha shaybaarka, Pyrroloquinoline quinone budada ayaa hoos u dhigtay dhaawaca ischemic, taasoo suurtagal ka dhigeysa hagaajinta tayada nolosha kadib istaroog.

Tan waxaa si cad loogu muujiyay qaabka xayawaanka ee ischemic stroke. Marka PQQ kabitaan waxaa la siiyay ka hor inta aan ischemia la kicin, waxay si weyn hoos ugu dhigtay xajmiga gobolka nudaha maskaxda ee dhaawacan. Waxaa la yaab leh, PQQ waxay leedahay saameyn difaac oo la mid ah xitaa markii la maamulay ka dib markii ischemia la kiciyay.26

Daraasad kale ayaa muujisay saameyn la mid ah dareemayaasha. Waxay sidoo kale muujisay in PQQ ay horseedday inay si weyn u horumariso dhibcaha neurobehavioral ka dib istaroogga.27 Natiijooyinkaas ayaa aad ugu farxay kuwa ka shaqeeya aagga ka hortagga iyo daweynta istaroogga aadanaha. Ujeeddada ayaa ah in bukaannada madax-dhiigfuranka lagu siin karo PQQ qolka gargaarka degdegga ah isla markaana ay yarayn karaan curyaaminta maskaxda.

Tixraaca

• Kim, J., Kobayashi, M., Fukuda, M., et al. Quinone-ka Pyrroloquinoline wuxuu xannibayaa fibrillation-ka borotiinka amyloid-ka ah Prion 4 (1), 26-31 (2010).
• Guan, S., Xu, J., Guo, Y., et al. Quinta loo yaqaan 'Pyrroloquinoline quinone' oo looga soo horjeedo glutamate-inagu-neurotoxicity-ga ee kujirta jirridda neerfaha iyo unugyada progenitor Int. J. Dev. Neurosci. 42, 37-45 (2015).
• Rucker R, Chowanadisai W, Nakano M. Muhiimadda jir ahaaneed ee pungroloquinoline quinone. Beddelka Med Rev. 2009; 14 (3): 268-77.
• Klinman JP, Bonnot F. Qeexdinta iyo iswaafajinta dariiqyada biosynthetic for enzymatic quinocofactors: PQQ, TTQ, CTQ, TPQ, iyo LTQ. Chem Rev. 2014; 114 (8): 4343-65.
• 5-ta Faa'iidadood ee Qaadashada Quful-tuurka Pyrroloquinoline (PQQ).

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