Products

Budada Palmitoylethanolamide (PEA) (544-31-0)

Budada Palmitoylethanolamide (PEA) waa amid acid acids dufan leh. Waa lugaha daciifka ah ee cannabinoid 1 (CB1) iyo cannabinoid 2 (CB2) qaatayaasha. Palmitoylethanolamide waxay ku dhaqaaqdaa iyada oo ku xiraya qaabilayaha cannabinoid aan la garanaynin kaas oo la mid ah CB2, waxay soo bandhigtaa anti-bararka, anti-nociceptive, neuroprotective, iyo guryaha lidka ku ah astaamaha 'vivo'. Soo saarista talaabooyin adag oo ka hortaga cudurada iyadoo la dhaqaajinayo PPARα, waxay u shaqeysaa sidii iskuduwaha xulashada ee loo yaqaan GPR55 receptors (EC50 = 4, 19 800 iyo> 30 000 nM at GPR55, CB2 iyo CB1 receiptors sidey u kala horreeyaan).

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

Palmitoylethanolamide (PEA) video budada

 

Palmitoylethanolamide (PEA) budada (544-31-0) Macluumaadka saldhigga ah

magaca Budada Palmitoylethanolamide (PEA)
CAS 544-31-0
xagiisayna saliideynta saliidda , biyaha la dhalaali karo, budada wanaagsan, budada guud
Magaca kiimikada Palmitoylethanolamide

N- (2-Hydroxyethyl) hexadecanamide

Isku mid ahaanshaha Palmidrol; Impulsin; 544-31-0; N-Palmitoylethanolamine; Palmitinsaeure-beta-hydroxyethylamid; (Hydroxyethyl) palmitamide; 2- (Palmitoylamino) ethanol; 2-Palmitamidoethanol; AM 3112; Loramine P 256; Mackpeart DR 14V; N- (2-Hydroxyethyl) Palmitamide; N-Hexadecanoylethanolamine; NSC 23320; Palmitic Acid Monoethanolamide; Palmitic Monoethanolamide
Formula kelli C18H37NO2
Miisaanka kelli 299.49
Dhibicda Biyaha 97-98 ° C
Muhiimadda InChI HXYVTAGFYLMHSO-UHFFFAOYSA-N
Form A adag crystalline
Imaanshaha Cad ilaa Off-White budada
Nolosha badh 0.292 Maalmood (12-h maalin; 1.5E6 OH / cm3)
milmi Dhibaatada DMSO (20 mM), ethanol (25 mM), chloroform, THF (at 30 ° C), iyo DMF (~ 10 mg / ml).
kaydinta Xaaladda Ku kaydi meel qabow oo qalalan, ka dheerow qorraxda tooska ah
Codsiga Palmitoylethanolamide waa astaamo loo yaqaan 'CB2 cannabinoid recepor agonist' iyo xulasho agonist GPR55
Dukumentiga Tijaabinta Available

 

Palmitoylethanolamide (digir) budada (544-31-0) budada Sharaxaad guud

Daawada loo yaqaan 'Palmitoylethanolamide' waa nooc ka mid ah cannabinoid laga helo maskaxda, beerka, iyo unugyada kale ee naasleyda ah. Waa liig daciif ah oo ka mid ah Cannabinoid 1 (CB1) iyo Cannabinoid 2 (CB2) soo dhaweeyayaasha, waxaa lagu ogaadey inay xakameyso dufanka asiidh amide hydrolase (FAAH) ((IC50 = 5.1 μM). waa N-nociceptive, anti-inflammatory, anti-convulsant iyo immunosuppresant activity.Waa N- (silsilad dheer-acyl) ethanolamine, endocannabinoid iyo N- (saturated fatty acyl) ethanolamine.Waxay ka soo baxdaa budada hexadecanoic. Palmitoylethanolamide budada wuxuu u dhaqmaa adoo ku xidhaya daaweeye cannabinoid ah oo aan la garanayn oo la mid ah CB2 Waxay sidoo kale u dhaqantaa sida firfircoone xulasho ee soo-dhoweynta GPR55.

Budada Palmitoylethanolamide, (oo sidoo kale loo yaqaan palmitoylethanolamine ama N-2 hydroxyethyl palmitamide), waa mid ka mid ah walxaha ugu badan ee loo adeegsado joojinta xanuunka iyo ka hortagga caabuqa waxaana loo muujiyey inay waxtar u leedahay xanuun daran iyo xanuun daba dheeraaday. Sababta oo ah maaddadu waxay u shaqeysaa sida xanuun joojiye dabiici ah, Waa ikhtiyaar u fiican daawooyinka caadiga ah ee sababi kara waxyeelada.

Budada "Palmitoylethanolamide" waxaa loo isticmaali jiray sannado badan Netherlands iyo Yurub, laakiin ilaa 1990dii xiisaha Mareykanka ayaa kor u kacay. Waxaa loo kala saaray "cunno ujeeddooyin caafimaad ah" oo Yurub dhexdeeda ah iyo kaabayaasha cuntada ee Maraykanka

 

Palmitoylethanolamide (PEA) Budada Taariikhda

Palmitoylethanolamide (PEA) budada, amide dabiici ah oo ku dhaca ethanolamine iyo palmitic acid, waa xinjir dhiiga ku jirta oo qaabeysa xanuunka iyo caabuqa. Xiisaha astaamaha anti-bararka ee budada Palmitoylethanolamide ayaa markii ugu horreysay lagu xusay horaantii 1950's by Coburn et al. (1954) oo ogaaday in quudinta doofaarka guinea cunno ay ku jirto ukunta ukunta ay ka ilaalinayso xasaasiyada tijaabada ah. Daraasadaha soo socda ayaa go'doomay oo la nadiifiyey budada Palmitoylethanolamide ee ukunta waxayna ogaadeen sifooyinka anti-bararka ee xayawaanka. Xiisaha cilmi baarista ee NAE ayaa dib loo soo nooleeyay 1990s kadib markii la helay NAE kale, AEA, oo leh astaamo la mid ah qaybta firfircoon ee xashiishadda. Xilliga loo yaqaan 'Cannabinoid receptors' (oo loo qoondeeyay CBi iyo CB2) iyo jiilka xulashooyinka xaddidan ee loo yaqaan 'CB receptor ligand' ayaa bixiyay aaladaha si loo sii dardargeliyo howlaha cilmi baarista. Tan iyo markaas kadib cadeymo la taaban karo oo laga soo aruuriyay xayawaanka iyo daraasaadka aadanaha ayaa muujiyay in budada Palmitoylethanolamide ay leedahay astaamo anti-bararka iyo xanuun joojiye marka lagu bixiyo habab kala duwan oo maamulka ah.

 

Palmitoylethanolamide (PEA) Farsamooyinka Ficil

Palmitoylethanolamide budadu waxay kicisaa tamar-kobcinta, baruurta gubta, iyo ka-hortagga bararka PPAR alpha. Kicinta borotiinkan muhiimka ah, budada Palmitoylethanolamide waxay joojisaa hawsha hiddo-wadeyaasha bararka iyo soo-saarka walxo badan oo barara.

Budada Palmitoylethanolamide waxay yareysaa howlaha firfircoon ee hidde ahaanta FAAH ee jabaya dabiiciga cannabinoid anandamide. Tani waxay kordhineysaa heerarka xasilloonida jirka ee anandamide jirkaaga, waxay ka caawineysaa la-dagaallanka xanuunka iyo kordhinta nasashada. Waxa kale oo laga yaabaa inay dhaqaajiso soo-dhoweynta qaatayaasha cannabinoid (CB2 iyo CB1).

Budada Palmitoylethanolamide waxay ka koobantahay maadada palmitic acid qaabkeeda. Bilawga lagu samaynayo budada Palmitoylethanolamide ee jirka ayaa si sax ah u ah aashitada dufanka badan.

Si kastaba ha noqotee, si fudud u kordhinta qaadashadaada palmitic acid ama dufanka kale ee cuntada ma saameyn doonto wax soo saarka budada Palmitoylethanolamide ee jirka. Tani waa sababta oo ah in jirkaagu u isticmaali doono budada Palmitoylethanolamide kaliya marka uu u baahan yahay magdhow caabuq ama xanuun, heerarkiisuna caadi ahaan way kala duwanaan doonaan maalinta oo dhan. Habka ugu wanaagsan ee lagu heli karo faa'iidooyinka budada Palmitoylethanolamide waa kaabis heerar ah, ama taa beddelkeeda cuntooyinka hodanka ku ah Palmitoylethanolamide.

 

Codsi Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) Powder waa astaamide-ka loo yaqaan 'endogennabinoid anandamide' (AEA), oo iska leh qoyska N-acylethanolamines (NAE). NAEs-da ayaa laga soo daayaa unugyada iyada oo laga jawaabayo dhiirrigelinta walaaca leh. Sida dhammaan NAEs, sidoo kale Palmitoylethanolamide (PEA) Powder waxay leedahay saameyn maxalli ah, iyo heerarka unugyadeeda waxaa si habsami leh loogu habeeyey iyada oo loo marayo isku-dheelitirka wax soo saarka iyo nabaad-guurka. Laba qulqulka loo yaqaan 'intracellular amidide', oo lagu muujiyey unugyada caabuqa, ayaa ku lug lahaa xaalufka lipid amide hydrolase (FAAH) iyo N-acylethanolamine hydrolyzing acid amidase (NAAA). Palmitoylethanolamide (PEA) Powder waxaa loo soo bandhigay inuu ku xidho receptor-ka unug-Nucleus-ka (Nukliyeerka Nuclear-ka) wuxuuna muujiyaa howlo badan oo baayooloji ah oo la xiriira xanuun daba-dheer iyo caabuq.

 

Palmitoylethanolamide (PEA) Baadhis dheeraad ah

Palmitoylethanolamide (PEA) Powder waa walax dabiici ah oo jirku soo saaro waxaana laga helaa cuntooyin kala duwan. Ma aha opioid. Ma ahan wax la qabatimo. Daraasadaha hordhaca ah waxay tilmaamayaan in Palmitoylethanolamide (PEA) Powder uusan horumarin dulqaadashada daawada ama si tartiib tartiib ah u luminayso waxtarka waqtiga sida ku dhacda opioids. Waxaa loo muujiyey inay badbaado u tahay bukaanada aan la soo sheegin waxyeelo daran waxaana loo tixgeliyaa inaysan laheyn sunta daran ama ba'an. Ma faragelineyso daaweynta kale ee daaweynta sidoo kale ma kicineyso isdhexgalka daroogada. Ma jiraan wax diidmo ah oo la og yahay oo loogu talagalay Palmitoylethanolamide (PEA) Powder, iyo bukaannada qaba shaqada kelyaha iyo beerka oo yaraaday waxaa lagu daaweyn karaa Powito Palmitoylethanolamide (PEA), maadaama ay dheef-shiid kiimikaadkeedu yahay mid maxalli ah isla markaana ka madax bannaan kelyaha iyo shaqada beerka. Sida dawooyin badan, nabadgelyada leh isticmaalka muddada dheer ee ka badan 60 maalmood si fiican looma baran in kasta oo teatku ay yihiin warbixino ku saabsan suugaanta isticmaalka muddada dheer iyada oo aan dhibaato la aqoonsan.

 

Tixraac Palmitoylethanolamide (PEA)

  • [1] Cruccu G, Di Stefano G, Marchettini P, Truini A.CNS Bartilmaameedka Daroogada ee Neurol Disord. 2019 Jul 3. doi: 10.2174 / 1871527318666190703110036. PMID: 31269891
  • [2] Noli C, Della Valle MF, Miolo A, Medori C, Schievano C; Kooxda Baadhitaanka Caafimaadka ee Kooxda 'Skinalia Clinical Research.Vet Dermatol'. 2019 Jun 24. doi: 10.1111 / vde.12764. PMID: 31237065
  • [3] Contarini G, Franceschini D, Facci L, Barbierato M, Giusti P, Zusso MJ Neuroinflammation. 2019 Jun 20; 16 (1): 126. doi: 10.1186 / s12974-019-1514-4. PMID: 31221190
  • [4] Boccella S, Marabese I, Iannotta M, Belardo C, Neugebauer V, Mazzitelli M, Pieretti G, Maione S, Palazzo E. Int J Mol Sci. 2019 Apr 9; 20 (7). Py: E1757. doi: 10.3390 / ijms20071757. PMID: 30970677
  • Palmitoylethanolamide (PEA) Miyuu Leeyahay Macaashka Miisaanku?

 

Maqaallada Daalacanaya