Budada Acacetin (480-44-4)

Acacetin (5,7-dihydroxy-4-methoxyflavone) ayaa ku baahsan guud ahaan Boqortooyada dhirta, laakiin waxay si gaar ah ugu badan tahay qoysaska Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae iyo Malvaceae. Waxaa la muujiyay in ay soo bandhigto saameyn xooggan oo ka hortagga glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase iyo xanthine oxidase enzymes.

Budada Acacetin 480-44-4 Macluumaadka Saldhig Kiimiko

Budada Acacetin 480-44-4 General Description

Budada Acacetin waa walxo cayriin oo Acacetin ah, taas oo ah flavone O-methylated si dabiici ah looga helo iniinaha safflower iyo dhir badan sida Saussurea involucrata ama xubnaha kale ee qoyska Asteraceae. Dhaqanka mesencephalic aasaasiga ah ee lagu soo bandhigay MPP +, acacetin ayaa la soo sheegay si loo ilaaliyo unugyada dopaminergic, tani waxay la xiriirtay hoos u dhaca NO, prostaglandin E2, iyo TNF-α. Intaa waxaa dheer, daawaynta acacetin ee lagu maamulo jiirarka MPTP-ku waxay wanaajisay cilladaha mootada ee ay keentay MPTP iyo unugyada dopaminergic ee la ilaaliyo ee striatum iyo SN. MPTP ay keentay firfircoonida microglia oo kordhay, sida ay ka muuqato kor u kaca iNOS iyo COX-2 muujinta striatum iyo SN, waxaa hoos u dhigay daawaynta acacetin.

Budada Acacetin 480-44-4 History

Acacetin (5,7-dihydroxy-4-methoxyflavone), oo ah qayb cunto ah, ayaa ku badan malab qudaar ah waxayna leedahay waxqabadyo ka hortagga kansarka oo sarreeya. Acacetin, apigenin, chrysin, iyo pinocembrin waa flavonoid aglycones oo laga helo cuntooyinka sida dhir, malab, celery, iyo shaaha chamomile. Flavonoids waxay u dhaqmi kartaa sidii substrates iyo horjoogayaasha enzyme CYP3A4, heme ka kooban ensaymes oo mas'uul ka ah dheef-shiid kiimikaadka seddex meelood meel daroogooyinka suuqa.

Budada Acacetin 480-44-4 Mfarsamada Of Action

Acacetin (5,7-dihydroxy-4-methoxyflavone) waxay hoos u dhigtay wax soo saarka αβ iyadoo faragalinaysa waxqabadka BACE-1 iyo isku dhafka APP, taasoo keentay hoos u dhac ku yimaada heerarka jajabyada APP-carboxy-terminal iyo APP intracellular domain. Sidaa darteed, saameynta ilaalinta acecetin ee wax soo saarka αβ waxaa dhexdhexaadiya nidaaminta qoraalka BACE-1 iyo APP, taasoo keentay hoos u dhaca borotiinka APP iyo dhaqdhaqaaqa BACE-1. Acacetin ayaa sidoo kale joojisay isku dhafka APP, taasoo keentay hoos u dhaca tirada amyloid plaques.

Budada Acacetin 480-44-4 Codsiga

1.Ururka Ka Hortagga Cudurrada Wadnaha iyo xididdada dhiigga

Acacetin (5,7-dihydroxy-4'-methoxyflavone) waa qaybta ugu wayn ee noolaha ee daawada dhaqameed ee Shiinaha "Snow lotus". Sida maadada flavonoid ee dabiiciga ah, waxaa la muujiyay in ay leedahay saameyn farmaajo wanaagsan sida anti-bararka, kansarka, iyo ka hortagga buurnaanta. Waxaa ka mid ah, doorkeeda caanka ah ee cudurada wadnaha (CVD) waxay ka heshay fiiro gaar ah culimada sanadihii ugu dambeeyay.

2.Hawlaha Kahortagga Kansarka Sare

Acacetin (5,7-dihydroxy-4'-methoxyflavone) waa koox flavonoid ah oo leh antimutagenic, antiplasmodial, antiperoxidant, anti-bararka iyo saamaynta kansarka.

Daraasadu waxay muujisay in acacetin ay xakamaysay jiritaanka unugyada DU145 iyada oo keentay apoptosis. Falanqaynta galbeedka ee calaamadaha kala duwan ee waddooyinka calaamadaynta ayaa shaaca ka qaaday in acacetin ay bartilmaameedsato Akt iyo factor factor (NF) -κB waddooyinka calaamadaynta iyadoo la xakameynayo fosforyaalka IκBα iyo NF-κB qaab ku-tiirsanaan ah. Iyada oo la raacayo awoodda ay u leedahay in ay keento apoptosis, xannibaadda acacetin-dhexdhexaadinta ee dariiqa badbaadada, Akt, iyo dariiqa NF-κB waxaa weheliya hoos u dhigista heerarka NF-κB-la xakameeyey borotiinnada anti-apoptotic, Bcl-2 iyo X-linked inhibitor of apoptosis protein (XIAP), iyo sidoo kale borotiinka proliferative, cyclooxygenase (COX) -2.

Acacetin waxay samaysaa saamaynta antitumor iyadoo la beegsanayo dariiqa calaamadaynta Akt/NF-kB.

3.Suurtagalnimada leh waxay ka hortagtaa saameynta anti-bararka iyo antioxidative ee sepsis

Acacetin waa flavonoid dabiici ah oo laga helo dhir kala duwan, oo ay ku jiraan Sparganii rhizoma, Sargentodoxa cuneata iyo Patrinia scabiosifolia. Sebsis waa jawaab-celin habaysan oo habaysan oo caabuqa, mana jiraan doorashooyin daweyn oo waxtar leh oo la heli karo. Daraasaduhu waxay daaha ka qaadeen in acacetin ay awood u leedahay inay ka hortagto caabuqa iyo saamaynta antioxidative ee sepsis.

4.Acacetin saamaynta ku leh cudurka Alzheimers

Cudurka Alzheimers (AD) waa xanuunka neerfaha iyo nooca ugu badan ee asaasaqa ee dalalka horumaray iyo kuwa soo koraya. Daraasadu waxay muujisay in acacetin ay saameyn wanaagsan ku leedahay cudurka Alzheimers.

5.Ka-hortagga caabuqa/waxqabadyada antinociceptive

Acacetin waa bioflavonoid leh sifooyin farmaajo sida antinociceptive/anti-bararka. Si kastaba ha ahaatee, caddaynta sayniska ee hawlaheeda spectrum iyo hababka ficilka lama yaqaan. Daraasadu waxay muujinaysaa in acacetin ay waxtar u leedahay daaweynta cudurrada la xiriira xanuunka.

Tixraaca

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2.Valkama, E; Salminen, JP; Koricheva, J; Pihlaja, K (2004). "Isbeddelka trichomes caleen iyo flavonoids epicuticular inta lagu jiro horumarinta caleen ee saddex bjørk taxa". Annals of Botany. 94 (2): 233–242. doi:10.1093/aob/mch131. PMC 4242156. PMID 15238348.

3.UmiKalsom, Yuusuf; Harborne, Jeffrey B. (1991). "Flavonoid qaybinta ferns asplenioid". Pertanika. 14 (3): 297-300.