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Iibso Sulforaphane Powder (4478-93-7) - Soosaarayaasha & Warshadaha

Budada Sulforaphane (4478-93-7)

Budfo Sulforaphane waa astaamo isku-dhafan qudaar laga soo saaray oo leh istiraatiijiyad ka hortag ah, kimikal ah iyo dhaqdhaqaaq ku daweyn, waxay horjoogsanaysaa fir-fircoonida TPA-duB ee dhaqdhaqaaqa NF-κB iyo muujinta COX-2 ee unugyada MCF-10A iyada oo xireysa laba dariiq oo kala duwan oo calaamadaha ah oo ay dhexdhexaadinayso ERK1 / 2-IKKα iyo NAK-IKKβ. Budfo Sulforaphane waxaa laga yaabaa inay ku yeelato saameyn weyn neuroprotective saamaynta yaraanta cholinergic iyo yaraanta garashada, waxay sidoo kale leedahay saameyn anti-bararka, ugu yaraan, qayb ahaan, oo la xiriirta faragalinta dariiqa NF-κB.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Sulforaphane Powder (4478-93-7) fiidiyow

 

Macluumaadka Saldhiga Sunta Ciidda ee Sulforaphane

magaca Budada Sulforaphane
CAS 4478-93-7
xagiisayna 1% ， 10%
Magaca kiimikada D, L-Sulforaphane
Isku mid ahaanshaha sulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R, S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-
Formula kelli C6H11NOS2
Miisaanka kelli 177.3
Barta Dhalaalka 68.93 ° C (Saadaaliyay)
Muhiimadda InChI SUVMJBTUFCVSAD-UHFFFAOYSA-N
Form Powder
Imaanshaha Midab lahayn oo Jaalaha ah
Nolosha badh /
milmi Chloroform (Si xoog leh), Methanol (Si tartiib tartiib ah)
kaydinta Xaaladda -20 ° C
Codsiga Awood leh, soo-xulli weji enzymes wajiga II-ga ah oo leh guryaha xinjirowga lidka ku ah. Waxay ku dhacdaa si dabiici ah broccoli. Waxaa la ogaaday inay xakameyso samaynta burooyinka naasaha ee jiirka. Wakiilka ka hortagga Antitumor.
Sulforaphane waxaa loo sheegay daraasad yar si loo yareeyo astaamaha la xiriira cudurka 'Autism'.
Dukumentiga Tijaabinta Available

 

Sulforaphane Tilmaanta Guud ee budada

Sulforaphane, in laga go'ay abuurkii Brassica oleracea L. var. botrytis L, waa qudaar iskutallaab-ka-soo-saar leh oo leh soosiocyanate firfircoon oo leh nashaadyo kimikal iyo is-daweyn. Budfo Sulforaphane waxay leedahay saameyn ka hortag ah oo ka dhan ah unugyada kansarka kaadiheysta iyada oo loo marayo marinka 'ROS-dhexdhexaadin ee maskaxda' apoptotic, iyo waxay soo jeedineysaa in walwalka ER iyo Nrf2 ay u matali karaan bartilmaameedyada istiraatiijiyadeed ee Sulforaphane-ka oo ay la socoto apoptosis. Sulforaphane waxaa laga yaabaa inuu ku yeesho saameyn weyn neuroprotective saamaynta yaraanta cholinergic iyo daciifnimada garashada. Boorashka Broccoli waxaa ku jira xaddi badan oo sulforaphane ah, oo sidoo kale laga helo khudaarta kale ee iskutallaabta lagu qodbo oo ay ka mid yihiin kaabash iyo kafee.

 

Sulforaphane Powder (4478-93-7) Taariikh

Budada Sulforaphane waa mid keli keli ah oo hadda dabiici ahaan ku jirta khudaarta si weyn loo cuno; waxay muujisay dhaqdhaqaaqyo xasaasiyad iyo wadne-xanuun.

Vitro: Sulforaphane wuxuu kiciyaa wareegga unug qaab qaab-ku-tiirsan, oo ay ku xigto geeri. Xiritaankan sulforaphane-ku-wareejinta wareegga unuggu wuxuu la xiriiray muujinta sii kordhaysa ee cyclins A iyo B1. Sulforaphane wuxuu kiciyaa geerida unugyada isagoo adeegsanaya hab bakhtiiye ah. Sulforaphane wuxuu xannibayaa dib-u-noolaashaha koritaanka wuxuuna yareynayaa suuragalnimada unugyada ee unugyada unugyada maskaxda ee loo yaqaan 'Kansarka carcinoma' (HT29) wuxuuna ku sumoobayaa sumad hooseysa unugyada CaCo2 ee kaladuwan. Daaweynta ka hor ee H9c2 rat myoblasts oo leh sulforaphane waxay yareysaa tirada unugyada apoptotic iyo muujinta borotiinka 'pro-apoptotic' (Bax, caspase-3 iyo cytochrome c), iyo sidoo kale kordhinta doxorubicin ee ku sii kordha awooda mitochondrial membrane. Intaa waxaa sii dheer, sulforaphane wuxuu kordhiyaa mRNA iyo muujinta borotiinka ee heme oxygenase-1, taas oo keentay in ay yareyso heerarka noocyada oksijiinta firfircoon (ROS, oo lagu cabiro isticmaalka MitoSOX Red reagent) ee ku dhaca mitochondria ee ay ku dhacdo doxorubicin.

Vivo: Sulforaphane waxay xannibi kartaa sameynta burooyinka ku dhaca amrooyinka ammary ee jiirka Sprague-Dawley oo lagu daweeyo qiyaaso kali ah oo ah 9,10-dimethyl-1,2-benzanthracene. Maamulka sulforaphane wuxuu yareeyaa dhacdada, isku dhufashada, iyo culeyska wuxuuna dib u dhigaa horumarka burooyinka naasaha ee hal mar oo ah DMBA oo ku jira jiirka dumarka Sprague-Dawley.

 

Sulforaphane Proder Mechanism Of Action

Tallaabooyinka Biochem / Fetiol

Xulashada xulashada ee wejiyada enzemeska wejiga II oo leh guryaha xinjirowga lidka ku ah. Xarunta Organosulfur waxaa laga helay khudaarta iskutallaabta lagu qodbo, oo ay ku jiraan broccoli.

Sulforaphane waa anti-kansar, anti-microbial iyo anti-diabetic compound oo laga helo khudaarta iskutallaabta. Waxay kicineysaa soosaarista enzymes-ka sida quinone reductase iyo glutathione S-transferase oo sababa isbedelka xinobiotic. Sulforaphane sidoo kale wuxuu kordhiyaa gudbinta borotiinka buro borotooriyada wuxuuna joojiyaa diakitka taranka. Waxay habeysaa jawaabaha bararka iyadoo la xakameynayo muujinta dhexdhexaadinta LPS ee iNOS, COX-2, IL-1β iyo TNF-α.

 

Codfo Sulforaphane Powder (4478-93-7)

Sulforaphane wuxuu ka hortagi karaa kansarka maqaarka markii si toos ah loo mariyo maqaarka. Sulforaphane waa Awood leh, xulato soo-saare enzymes wajiga II-ga ah ee leh astaamaha cudurka anticarcinogenic. Waxay ku dhacdaa si dabiici ah broccoli. Waxaa la ogaaday inay xakameyso samaynta burooyinka naasaha ee jiirka. Wakiilka ka hortagga Antitumor.
Sulforaphane waxaa loo sheegay daraasad yar si loo yareeyo astaamaha la xiriira cudurka 'Autism'.

 

Sulforaphane Powder (4478-93-7) Daraasad dheeri ah

Sulforaphane wuxuu soo bandhigayaa dawooyinka lidka ku ah astaamaha, dawooyinka lidka ku ah sunta, iyo astaamaha dawooyinka lagu daweeyo ee moodooyinka tijaabada ah. Waxaa laga helaa khudaarta iskutallaabta lagu qodbo sida broccoli, sprouts Brussels ama kareemada. Enrosme myrosinase wuxuu isu beddelaa glucoraphanin, glucosinolate, oo loo beddelaa sulforaphane dhaawaca soo gaadha warshadda (sida cunidda). Caleemaha yar yar ee broccoli iyo cadcad waxay si gaar ah hodan ugu yihiin glucoraphanin.

 

Sulforaphane Powder (4478-93-7) Tixraac

  • Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator oo leh Raad-reebka Agonistic Hoose, Jawaabta laga Hortago Bell-Shaped in Production Vitro BDNF. J Pharmacol Exp Ther. 2018 Mar; 364 (3): 377-389. doi: 10.1124 / jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
  • Zhang, Y., et al .: Proc. Natl. Acad. Sci. USA, 89, 2399 (1992), Shikita, M., et al .: Biochem. J., 341, 725 (1999), Wittich, S., et al:: J. Med. Chem., 45, 3296 (2002), Lee, J., et al .: Cancer Lett., 224, 171 (2005); Chem. iyo Eng. Wararka, p 11, Oct. 20 (2014)
  • Gamet-Payrastre L, et al. Sulforaphane, oo si dabiici u ah ku dhaca 'isothiocyanate', wuxuu kadhigaa xarigga wareegga unugyada iyo qanjidhada unugyada kansarka mindhicirka ee HT29. Kansarka Res. 2000 Mar 1; 60 (5): 1426-33.
  • Li B, et al. Sulforaphane wuxuu ka hortagaa walaaca fekerka ee doxorubicin iyo dhimashada unugga ee unugyada H9c2. Int J Mol Med. 2015 Jul; 36 (1): 53-64. [3]. Zhang Y, et al. Waxqabadka Anticarcinogenic ee sulforaphane iyo qaabdhismeedka qaab dhismeedka la xiriira ee loo yaqaan 'Norbornylisothiocyanates'. Proc Natl Acad Sci US A. 1994 Apr 12; 91 (8): 3147-50.
  • 2020 Glucoraphanin Vs. Sulforaphane: Antioxidant-ka ugu wanaagsan iyo Nafaqooyinka Ugu Wanaagsan ee Broccoli

 

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