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CAS 38183-03-8

7,8-Dihydroxyflavone budada

7,8-Dihydroxyflavone, oo sidoo kale loo yaqaan tropoflavin, waa flavone si dabiici ah u dhacda oo laga helo Godmania aesculifolia, Tridax procumbens, iyo caleemaha geedka primula.[2][3][4] Waxaa la ogaaday inuu u dhaqmo sidii awood yar oo door ah agonist yar-yar ee tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), soo-dhoweynta ugu weyn ee soo-dhoweynta neurotrophin ee maskaxda-derived neurotrophic factor (BDNF). Tropoflavin labadaba afka ayaa laga heli karaa oo awood u leh inuu galo xannibaadda dhiigga-maskaxda. Daawooyinka tropoflavin oo leh awood aad u wanagsantay iyo farmashiyaha, R13 (iyo, hore, R7), ayaa ku socda horumarinta daaweynta cudurka Alzheimers.

Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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7,8-Dihydroxyflavone budada Macluumaadka Saldhigga Kiimikada

magaca 7,8-DIHYDROXYFLAVONE
CAS 38183-03-8
xagiisayna 98%
Magaca kiimikada 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Isku mid ahaanshaha 7,8-DHF; 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one; 8-Dihydroxyflavone; 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on
Formula kelli C15H10O4
Miisaanka kelli 254.24
Barta Boling 494.4 ° C at 760 mmHg
Muhiimadda InChI COCYGNDCWFKTMF-UHFFFAOYSA-N
Form adag
Imaanshaha Budada jaalaha ah
Nolosha badh /
milmi DMSO: ≥ 100 mg/ml (393.33 mm)

Ku milmay DMSO, ethanol, iyo methanol.
kaydinta Xaaladda qolka kulaylka
Codsiga 7,8-Dihydroxyflavone waa agonist TrkB oo joojisa apoptosis-kicinta glutamate
Dukumentiga Tijaabinta Available

 

7,8-Dihydroxyflavone budada Sharaxaada Guud

7,8-Dihydroxyflavone (7,8-DHF) waa flavone monophenolic leh saameyno kala duwan. Waxay u shaqeysaa sida agonist neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), ilaalinta neerfayaasha muujinaya TrkB ee apoptosis.1 7,8-DHF waa neuroprotective ee qaabka xayawaanka ee cudurka Parkinson.1 Waxay taageertaa barashada dareenka ee jiirarka. waxayna dib u celisaa cilladaha xusuusta ee qaabka jiirka ee cudurka Alzheimers.2,3 Waxay sidoo kale hagaajinaysaa dhaqdhaqaaqa dhaqdhaqaaqa waxayna kordhisaa badbaadada qaabka xayawaanka ee cudurka Huntington.4 7,8-DHF waxay joojisaa cytochrome P450 aromatase (IC50 = 10 µM) iyo, Sidan oo kale, waxay bedeshaa dheef-shiid kiimikaad estrogen.5 Waxa kale oo ay leedahay ficil-antioxidant taasoo kordhisa isku-dhafka glutathione intracellular waxayna baabi'isaa noocyada ogsijiinta fal-celinta.

 

7,8-Dihydroxyflavone Budada Taariikhda

2017, caddaynta ayaa la daabacay oo soo jeedinaysa in tropoflavin iyo noocyo kala duwan oo kale oo la soo sheegay-yar-yar oo TrkB agonists laga yaabo inaysan dhab ahaantii noqonin agonists tooska ah ee TrkB oo laga yaabo inay dhexdhexaadiyaan saameyntooda la arkay siyaabo kale.

 

7,8-Dihydroxyflavone budada Mfarsamada Of Action

7,8-Dihydroxyflavone waa tyrosine kinase reseptor B (TrkB) agonist receptor ah. Waxay muujinaysaa dhammaan saameynta daaweynta ee maskaxda ka soo baxda neurotrophic factor (BDNF) - sida ilaalinta neerfayaasha apoptosis, ka hortagga sunta kain acid-ku-soo-baxa, hoos u dhigista xajmiga istaroogga, iyo neuroprotecting ee qaabka xayawaanka ee cudurka Parkinson-la'aanteed astaanta farmashiyaha liidata ee BDNF oo xaddidaysa awooddeeda daawaynta.

7,8-Dihydroxyflavone (7,8-DHF) ayaa laga yaabaa in loo isticmaalo in lagu caawiyo aqoonsiga iyo kala soocida saameynta jireed iyo dariiqyada calaamadaha unugyada ee dhexdhexaadinta firfircoonida TrkB, sida kuwa ku lug leh, xusuusta, vasorelaxation iyo hypertension. 7,8-DHF waxay soo saartaa ilaalinta scopolamine ee ay keentay Alzheimer-ka cilladda pathologic.

 

Codsiga budada 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone hydrate ayaa loo isticmaalay sida tropomyosin-receptor-kinase B (TrkB) agonist ee jiirarka iyo in la joojiyo TrkB si loola socdo qulqulka postsynaptic ee kacsan (eEPSCs).

 

7,8-Dihydroxyflavone budada cilmi baaris dheeraad ah

Kala duwanaansho qaabdhismeedka dhow ee tropoflavin ayaa sidoo kale la ogaaday inay u dhaqmaan sida TrkB agonists in vitro, oo ay ku jiraan diosmetin (5,7,3'-trihydroxy-4'-methoxyflavone), norwogonin (5,7,8-trihydroxyflavone), eutropoflavin. (4'-dimethylamino-7,8-dihydroxyflavone), 7,8,3'-trihydroxyflavone, 7,3'-dihydroxyflavone, 7,8,2'-trihydroxyflavone, 3,7,8,2'-tetrahydroxyflavone, iyo 3,7-dihydroxyflavone.[37] Gossypetin analooga ah ee aadka loo isticmaalo (3,5,7,8,3′,4′-hexahydroxyflavone), liddi ku ah, wuxuu u muuqdaa mid ka soo horjeeda TrkB in vitro.

Tropoflavin ayaa sidoo kale la ogaaday inuu hoos u dhigo hurdada jiirka ee wejiga mugdiga wuxuuna yareeyaa heerka hypothalamus ee orexin A laakiin maaha orexin B ee jiirarka.

 

Tixraaca

  1. Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, xannibaya xusuusta meel fog ee muddada-dheer oo ay keento walbahaarka dhaqdhaqaaqa dhaqdhaqaaqa ee jiirka. Hippocampus 22 399
  2. Jang et al (2010) agonist TrkB xulashada leh oo leh waxqabadyo neurotrophic ah oo awood leh 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268
  3. Boltaev U, Meyer Y, Tolibzoda F, Jacques T, Gassaway M, Xu Q, Wagner F, Zhang YL, Palmer M, Holson E, Sames D (2017). "Qiimaynta tirada badan ee Multiplex waxay muujinaysaa baahida loo qabo dib-u-qiimaynta agonistayaasha TrkB-yar ee la soo sheegay". Calaamada Sci
  4. Jiang Small-molecule TrkB agonistayaasha soo dhaweeya waxay hagaajiyaan shaqada dhaqdhaqaaqa waxayna kordhiyaan badbaadada moodeelka jiirka ee cudurka Huntington. Hum.Mol.Gnet. 2013

 

 

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