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Budada Tianeptine Sodium (30123-17-2)

Budada Tianeptine sodium budada ah ayaa ah xulasho kor u qaadeysa kor u qaadida serotonin ee maskaxda iyadoo aan wax saameyn ah ku laheyn noradrenalin ama qaadashada daawada dopamine. Daawada murugada ee caafimaad ahaan waxtar leh. Wuxuu soo bandhigayaa saameynta neuroprotective ee hypoxia ee dhaqanka unugyada iyo ka hortagga waxyeelada halista ah ee cytokines ee vivo.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

Budada Tianeptine Sodium (30123-17-2) fiidiyow

 

Tianeptine Sodium budada (30123-17-2) Macluumaadka Saldhigga

magaca Budada Tianeptine sodium
CAS 30123-17-2
xagiisayna 98%
Magaca kiimikada 7 - [(3-Chloro-6,11-dihydro-6-methyl- 5,5-dioxidodibenzo [c, f] [1,2] thiazepin-11-yl) amino] heptanoic acid sodium salt
Isku mid ahaanshaha Sodium-ka Tianeptine
Tianeptine sodium30123-17-2
Sodium-ka Tianeptine
Stablon
Coaxil
Formula kelli C21H24ClN2NaO4S
Miisaanka kelli 458.93
Dhibicda Biyaha 148-150 ° C
Muhiimadda InChI ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Form Solid
Imaanshaha Cadaan ilaa Tan Powder
Nolosha badh Lama heli karo
milmi Dhibaatada biyaha (92 mg / ml at 25 ° C), DMSO (92 mg / ml at 25 ° C), ethanol (92 mg / ml at 25 ° C), iyo methanol.
kaydinta Xaaladda Heerkulka qolka (desiccate)
Codsiga Sida kor u qaadista kobcinta maskaxda ee maskaxda ee wax ku ool ah oo aan lahayn wax saamayn ah noradrenalin ama qaadashada dopamine.
Dukumentiga Tijaabinta Available

 

Tianeptine Sodium Guud Qeexid Guud

Budada Tianeptine waa dawada sunta ka hortagga. Waa agonist of pt-opioid receptor (MOR; EC50s = 194 iyo 641 nM oo loogu talagalay soo-dhoweynta bini-aadamka iyo jiirka, siday u kala horreeyaan, dib u dhac ku yimaadda BRET ee loogu talagalay firfircoonaanta borotiinka G) iyo sidoo kale waxay saameyn ku leedahay nidaamka sumowga. Tianeptine (30 mg / kg) wuxuu yareynayaa xasilooni la’aanta tijaabada dabaasha qasabka ah ee nooca duurjoogta ah, laakiin ma ahan jiirka 'MOR knockout', taasoo muujineysa waxqabadka antidepressant-u eg ee ku tiirsan MORs. Waxay kordhisaa waxqabadka dhaqdhaqaaqa qiyaasta 30, laakiin maaha 10 mg / kg, tijaabada gudaha furan waxayna kordhisaa daahfurka cuncunka ee tijaabada saxanka kulul ee jiirarka. Tianeptine waxay wax ka badashaa howlaha soo dhoweynta AMPA iyadoo sii kordhineysa fosfooraska hoosaadka AMPA receptor GluR1 qeybta hore ee kiliyaha iyo qeybta hunguriga CA3 ee jiirka. Waxay ka hortageysaa kororka glial glutamate sideer 1 (GLT-1) muujinta kicinta xakameynta dabadheeraatay ee gobolka hunguriga caloosha ee caanka ah ee loo yaqaan 'hippocampal CA3' ee jiirka markii lagu qaadanayo 10 mg / kg maalintiiba 21 maalmood. Waxay kaloo dib ugalaabaysaa kororka heerarka glutamate-ka extracellular-ka ah ee ay kujirto walaaca xakamaynta daran ee xuddunta xudunta u leh amygdala ee jiirka.

 

Taariikh Nololeedka budada Tianeptine Sodium

Budada Tianeptine sodium budada ah ayaa ah xulasho kor u qaadeysa kor u qaadida serotonin ee maskaxda iyadoo aan wax saameyn ah ku laheyn noradrenalin ama qaadashada daawada dopamine. Daawada murugada ee caafimaad ahaan waxtar leh. Wuxuu soo bandhigayaa saameynta neuroprotective ee hypoxia ee dhaqanka unugyada iyo ka hortagga waxyeelada halista ah ee cytokines ee vivo. Induces mTORC1 firfircoon ee neurons rat hippocampal iyo waxay kordhisaa dendritic dgritic, cufnaanta lafdhabarta iyo borotiinka synaptic. Kaqaybqaatayaasha LPS-firfircoonaanta firfircoonida ee unugyada microglial ee dhaqanka.

 

Farsamada Tianeptine Sodium

Isuduwaha xulashada ee qaadashada 5-HT ee vitro iyo vivo. Ma laha wax xiriir ah oo ballaaran oo soo-dhoweeyeyaal ah, oo ay ku jiraan 5-HT iyo dopamine (IC50> 10 μM) wax saameyn ahna kuma leh noradrenalin ama qaadashada dopamine. Dawada lidka ku ah diiqadda, xanuun joojiyaha iyo neerfaha ee maamulka ka dambeeya ee ku habboon vivo.

Tianeptine (magacyada ganacsiga Stablon iyo Coaxil) waa xarun dawooyin oo badanaa loo isticmaalo daaweynta niyad-jabka caafimaad. Waxaa sidoo kale mararka qaarkood loo isticmaalaa in lagu daaweeyo xanaaqa xanaaqa ama neefta. Qiyaasta culus waxaa la sheegay in ay soo saarto wax-soo-jiidashada opioid-sida madadaalada iyo kicinta, dhiirigelinta dhiirrigelinta, iyo buurnaanta marka la maamulayo.

Marka la eego kala soocista kiimikada, tianeptine waa tricyclic antidepressant (TCA). Si kastaba ha noqotee, dawadeeda iyo saamaynta dawladu way ku kala duwanaan karaan kuwa caanka ah ee dawada lidka ku ah iyo dawada xasaasiga ah, inta badan xaqiiqda ah in aan loo malaynaynin inay si dhakhso ah wax uga qabato nidaamka xakamaynta neurotransmitters (sida serotonin, dopamine, iyo noradrenaline). wax ka qabtaan farsamooyinka glutamate iyo glutamatergic, oo keenaya maskaxda inay si sahal ah ula qabsadaan buufiska iyo diiqadda.

 

Codsiga Tianeptine Sodium

Sodium-ka ayaa loo diley sidii istitaatiin wanaagsan oo steatosis-positive ah unugyada HepG2 Tianeptine waxaa sidoo kale loo isticmaalay in lagu darsado saameynta ay ku yeelato jiirka ka soo baxa tijaabooyinka adkeysiga dabaasha (SETs). Daraasadani waxay soo bandhigtay in tianeptine ay kordhisay waqtiga dabaasha ee jiirka ee lagu arko SET. Intaa waxaa sii dheer, tianeptine waxay sidoo kale kordhisay wadarta kolestaroolka iyo LDL, halka heerarka triglyceride ay hoos u dhacday. Sidaa daraadeed, tianeptine waxaa laga yaabaa inuu ku lug yeesho cudurka loo yaqaan 'pathogenesis of syndrome syndrome'.

 

Tianeptine Sodium Cilmi Baaris Dheeraad ah

Tianeptine sodium waa wakiilka lidka biyaha ka-hortagga ee lidka ku ah biyaha. Marka la barbardhigo dawooyinka lidka ku ah astaamaha 'tricyclic antidepressants or Selective serotonin reuptake inhibitors (SSRIs), tianeptine waa xulasho kobcin serotonin reuptake ah (SSRE) maskaxda waxayna yareyneysaa walaaca-walaaca neuronal dendrites. (Badeecada waxaa loogu talagalay ujeedo cilmi baaris oo keliya.) Tijaabooyinka kiliinikada ee tianeptine waxay soo jeedinayaan inay la mid tahay kuwa kale oo caan ku ah dawooyinka lidka ku ah cudurka sida fluoxetine (SSRI) iyo amitriptyline (TCA). Si kastaba ha noqotee, Tianeptine waxay u muuqataa inay muujineyso waxyeellooyin yar iyo dhibaatooyin ka badan dawooyinka lidka ku ah dawooyinka lidka ku ah.

Marka lagu daro saameynteeda niyadjabka, tianeptine sidoo kale waxay soo bandhigtaa waxyaabo anxiolytic ah (anti-walwal), gaar ahaan muujinaya ballanqaad ku saabsan daaweynta dhibaatooyinka argagaxa. Tianeptine sidoo kale waxay soo bandhigtaa astaamaha neerfaha iyo hagaajinta garashada bukaanka qaba niyad-jabka. Tianeptine saamayn la'aanta iyo kor u qaadista niyadda, marka lagu daro faa'iidooyinka neerfaha iyo garashada, waxay ka dhigeysaa nootropic caan ah.

Tilmaamaha qoritaanka ayaa muujinaya in tianeptine lagu qaadanayo 12.5 mg qiyaasood oo la qaado seddex jeer maalin kasta, oo sugaya 3-4 saacadood inta u dhexeysa qiyaasta.

 

Ti tixraaca Tianeptine Sodium

 

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