Budada Unifiram (DM232) (272786-64-8)

Unifiram (DM232) budada (272786-64-8) fiidiyaha

Unifiram (DM232) Base Xogta budada

Unifiram (DM232) General Description

Unifiram waa mid cusub daroogada nootropic taasi waxay noqon kartaa mid ka mid ah kaabeyaasha maskaxda ee ugu awoodda badan ee abid la hindiso.

Sida laga soo xigtay maqaal ku yaal Cilmi -baarista Horumarinta Daroogada, xaruntan waxay ku faantaa awood qiyaastii 1,000 jeer ka weyn tan hadda la heli karo nootropics sida Piracetam iyo Aniracetam.

Daraasadaha ayaa muujiyey in Unifiram uu saameyn aad u wanaagsan ku yeeshay waxqabadka xusuusta iyo is-miyir-qabka ee la mid ah kuwa ay soo bandhigtay kooxaha caanka ah ee Racetams.

Unifiram wuxuu xiriir dhaw la leeyahay Sunifiram wuxuuna ku shaqeeyaa heer kor loogu qaado maskaxda oo isku mid ah cabirka qiyaasta. Sababta oo ah helitaanka xadidan ee Unifiram, dadka badankood waxay u qaadan doonaan Sunifiram bedel ku habboon xaruntaan qaaliga ah.

Unifiram (DM232) Taariikhda budada

Unifiram (CAS # 272786-64-8) waa walax la soo sheegay sanadkii 2000 inay leedahay sifooyin la mid ah budhcad-badeedda laakiin waxay awood badan ku leedahay baaritaanka ka-hortagga jiirka. Unifiram (magaca nambarka kobcinta DM-232) waa daawo tijaabo ah. taasi waxay leedahay antiamnesic iyo saameyn kale oo ku saabsan daraasaadka xayawaanka oo leh awood aad uga weyn tan piracetam. Tiro ka mid ah xeryahooda la xiriira ayaa la yaqaan, sida sunifiram (DM-235) iyo sapunifiram (MN-19). [4] [5] [6] Unifiram waxay leedahay laba enantiomers, iyadoo qaabka dextro uu yahay isomer firfircoon. Waxaa la muujiyey inay yareyneyso muddada hypnosis ee ay keento pentobarbital, iyadoo aan wax u dhimayn isuduwidda mootada. Laga soo bilaabo 2015, ma jirin daraasad rasmi ah oo bini-aadam ah oo leh labbis.

Sannadkii 2006, cilmi baadhayaashu waxay barteen astaamaha dawooyinka labada dawadood ee Sunifiram iyo Unifiram, iyagoo ogaanaya in labada xeryood ay ahaayeen amar ka kooban afar weyne oo ka awood badan Pircatem. Unifiram, waxay ogaadeen, inay awood u leedahay inay ka hortagto amnesia iyada oo loo marayo modulation dhowr nidaam oo neerfaha ah.

Unifiram (DM232) Farsamooyinka Ficil

Unifiram waa qaab-dhismeedka allosteric-ka wanaagsan ee soo-dhoweeyeyaashaada AMPA. Ampakine ahaan, Unifiram wuxuu saameyn ku yeeshaa glutamate ee maskaxda taasoo keeneysa isku gudbinta ugufiican ee neerfaha.

Unifiram waxa kale oo ay kicisaa wax soo saarka acetylcholine taasoo ka dhigaysa hab dhaqankeeda mid la mid ah Noopept, Pramiraceta, Oxiracetam iyo nootropics kale racetam.

Ma jirto baaritaan aan loo baahnayn Unifiram oo ka badan kuwa dhiggooda ah Sunifiram, laakiin labadan kiimiko ayaa si dhow ula xiriira waxayna aaminsan yihiin in ay ka shaqeeyaan siyaabo isku mid ah.

Natiijooyinka daraasadaha ku saabsan firfircoonaanta AMPA-receptor ee ku lug leh saameynta antiamnesic ee Unifiram waxay soo jeedinayaan, in Unifiram u dhaqmo sida kor u qaadida garashada iyada oo loo marayo hawlgelinta nidaamka AMPA-dhexdhexaadinta neurotransmission. Xaruntan, in kasta oo aan muujinaynin xidhiidhka isku xidhka daraasadaha loogu talagalay soo-dhoweynta dhexe ee ugu muhiimsan ama kanaalada, waxay awoodaan inay ka hortagaan amnesia oo ay keento hab-nololeedka dhowr nidaam oo neurotransmission ah waxayna awood u leedahay inay kordhiso sii-deynta acetylcholine ee kortex maskaxda, ugu yaraan daraasadaha ku saabsan jiirka. .

Codsi Unifiram (DM232)

DM232 (unifiram) waa AMPAkine-nootropic seddex amar oo baaxad weyn oo ka xoog badan piracetam ee daraasaadka xoolaha.

Daraasadda dhexdeeda, waxaa la arkay in unifiram uu leeyahay faa iidooyinka soo socda; ka-hortagga daweynta iyo ka-hortagga hypnotic-ga, anti-amnesia iyo agonism-ka acetylcholine. Hal daraasad, waxaa lagu ogaadey in unifiram ay yareyn karto saameynta caqabad-ku-taagga oo ah hypnosis iyo is-dejin. Maaddaama ay acetylcholine si xoog leh ugu xidhantahay xusuusta iyo waxbarashada oo la wanaajiyey, unifiram ayaa sidaas darteed noqon kara mid waxtar u leh horumarka maskaxda.

Unifiram (DM232) Baadhis dheeraad ah

Unifiram waa daroogo ku jirta qoyska racetam. Qaab dhismeedkeedu waa sida ampakine, waxayna si dhow ula xiriirtaa Sunifiram. Unifiram waa mid ka mid ah kuwa ugu awoodda badan kaabiska maskaxda. Caddaynta ayaa muujisay in ay kun jeer ka xoog badan tahay aniracetam. Tijaabooyinka kiliinikada ee sanadaha ayaa muujiyay in unifiram ay kor u qaadi karto xusuusta iyo hagaajinta awoodaha garashada sida nootropics kale ee racetam. Daraasaduhu waxay muujiyeen in unifiram uu yahay qalab wax-qabsi leh oo AMPA ah oo togan.

Waxay u shaqeysaa si loo yareeyo saamaynta kuwa ka soo horjeedka kooxaha ka soo horjeeda NMDA, muscarinic iyo AMPA. AMPA iyo NMDA antagonist waxay nuqul ka dhigaan shaqada glutamate, sababtaas awgeed, waxay si toos ah ulaxiriiraan xusuusta iyo barashada maskaxda. Waxay sidoo kale awood u leedahay inay xakameyso qaadashada glutamate ee maskaxda sidaa darteed waxay wanaajineysaa gudbinta neerfayaasha maskaxda. Sida piracetam, oxiracetam, pramiracetam iyo noopept, waxay kicisaa wax soo saarka acetylcholine.

Tixraaca Unifiram (DM232)

• Soo-koobidda Isku-darka CID 9861054. (2018). PubChem: Buugga Xogta Furan ee Chemistry, Maktabadda Qaranka ee Daawada [internetka]. Waxaa laga heli karaa: https://pubchem.ncbi.nlm.nih.gov/compound/9861054 [Waxaa Lahelay July 19, 2018]
• Isku-darka Enantioselective iyo qiimeynta daaweynta ee horudhaca ah ee loo yaqaan 'enantiomers of uniform' (DM232), oo ah wakiil awood u leh kor u qaadista garashada -
• Galeotti, N .; Ghelardini, C .; Pittaluga, A .; Pugliese, A .; Bartolini, A .; Manetti, D .; Romanelli, M .; Gualtieri, F. (2003). "Waxqabadka AMPA-receptor wuxuu ku lug leeyahay saameynta antiamnesic ee DM 232 (unifiram) iyo DM 235 (sunifiram)". Naunyn-Schmiedeberg Diiwaanka Farmasiga. 368 (6): 538– doi: 10.1007 / s00210-003-0812-6. PMID 14600801.
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