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Methylselelenocysteine ​​​​budada 26046-90-2

Selenium waa macdanta raadraaca lagama maarmaanka ah. Enzymes Antioxidant waxay inta badan ku jiraan selenium waxayna unugyada ka ilaaliyaan waxyeelada oksaydhka. Se-methylseleno-L-cysteine ​​(oo loo yaqaan methylselenocysteine) ayaa si dabiici ah looga helaa khudaarta sida toonta iyo brokoli waxaana loo isticmaalaa kabka nafaqeynta. Daraasado lagu sameeyay moodooyinka xayawaanka ayaa muujiyay in Se-methylseleno-L-cysteine ​​(Methylselelenocysteine) ay waxtar u leedahay ka hortagga kansarka. Nidaamkeeda ficilka ayaa lagu soo waramayaa inay tahay iyada oo la joojinayo noocyada ogsijiinta ee fal-celiska ah.

Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

Budada Methylselelenocysteine ​​ee Macluumaadka Saldhigga Kiimikada

magaca Methylselelenocysteine
CAS 26046-90-2
xagiisayna 98%
Magaca kiimikada 3-(methylseleno)-L-alanine
Isku mid ahaanshaha Se-methylselenocysteine

Se-(Methyl) seleno-L-cysteine

3-(Methylseleno)-L-alanine

(R) -2-Amino-3- (methylselanyl) propanoic acid

Methylselelenocysteine

Formula kelli C4H9NO2Se
Miisaanka kelli 182.09
Barta Boling /
Muhiimadda InChI XDSSPSLGNGIIHP-VKHMYHEASA-N
Form budo
Imaanshaha Caddaan si cad budada cad
Nolosha badh /
milmi Ku milmay biyaha (5 mg/mL).
kaydinta Xaaladda RT
Codsiga nafaqaynta, kaabista cuntada
Dukumentiga Tijaabinta Available

 

Methylselelenocysteine ​​​​budada 26046-90-2 General Description

Selenium waa macdanta raadraaca lagama maarmaanka ah. Enzymes Antioxidant waxay inta badan ku jiraan selenium waxayna unugyada ka ilaaliyaan waxyeelada oksaydhka. Se-methylseleno-L-cysteine ​​(oo loo yaqaan methylselenocysteine) ayaa si dabiici ah looga helaa khudaarta sida toonta iyo brokoli waxaana loo isticmaalaa kabka nafaqeynta. Daraasado lagu sameeyay moodooyinka xayawaanka ayaa muujiyay in Se-methylseleno-L-cysteine ​​(Methylselelenocysteine) ay waxtar u leedahay ka hortagga kansarka. Nidaamkeeda ficilka ayaa lagu soo waramayaa inay tahay iyada oo la joojinayo noocyada ogsijiinta ee fal-celiska ah.

 

Methylselelenocysteine Mfarsamada Of Action, Methylselelenocysteine Faa'iidooyinka

Methylselelenocysteine ​​budada ah waa asiidh selenoamino ah oo si dabiici ah looga helo khudaarta sida toonta iyo brokoli. Waa qaab noole la heli karo oo badbaado leh oo ka mid ah nafaqeynta macdanta muhiimka ah, selenium. Selenium oo ah qaabka Selenocysteine ​​​​waa qayb muhiim ah oo ka mid ah enzymes-ka antioxidant sida glutathione peroxidase waxaana sidoo kale laga helaa borotiinno dhowr ah oo jirka ah.

Enzymes Antioxidant oo ay ku jiraan selenium, waxay unugyada ka ilaaliyaan waxyeelada oksaydhka. Daraasado lagu sameeyay moodooyinka xayawaanka ayaa muujiyay in faa'iidooyinka Methylselelenocysteine ​​​​ay waxtar u leeyihiin ka hortagga kansarka. Habka ficilka ee methylselenocysteine ​​ee moodooyinkaas, ayaa la rumeysan yahay in ay tahay iyada oo loo marayo jiilka noocyada selenium ee monomethylated by enzymes endogenous. Kuwani waxay soo saaraan superoxide waxayna keenaan apoptosis (dhimashada unugyada qorshaysan) iyagoo joojinaya kororka unugyada kansarka. Methylselelenocysteine ​​laguma darin borotiinnada jirka, taasoo ka dhigaysa gebi ahaanba bioavailable for chemoprevention, iyo synthesize of selenium-ka kooban enzymes sida glutathione peroxidase.

Selenium waa nafaqeeyayaalka yar yar ee lagama maarmaanka u ah wanaagga aadanaha. Qaadashada selenium oo aan ku filnayn waxay keentaa yaraanta taasoo keenta xaalado cudur oo kala duwan. Selenium waxay si dabiici ah ugu jirtaa dhowr cunto oo dhir iyo xayawaan ah. Nuska Brazil, walnuts, badarka, hilibka iyo cuntooyinka badda ayaa ah ilo wanaagsan oo laga helo selenium. Soo-gaadhista cuntada ee ilahan waxay ku kala duwan tahay goobta juqraafiyeed, iyadoo ku xiran maadada selenium ee ciidda. Xaaladaha marka xaddi ku filan oo selenium ah aan laga heli karin kheyraadka dabiiciga ah ayaa dammaanad qaadaya isticmaalka kaabayaasha selenium.

Cilmi-baaristu waxay daaha ka qaadaysaa in dheef-shiid kiimikaadka selenium ee monomethylated loo baahan yahay faa'iidooyinka ka hortagga kiimikaad ee xeryahooda selenium. Daraasad dhowaan la sameeyay ayaa qiyaaseysa in gamma-glutamylmethylselenocysteine ​​​​ laga helay toonta selenium sare, u adeegta ugu horrayn sida side Methylselelenocysteine ​​​​, kaas oo la muujiyey inuu yahay wakiilka kiimikaad ee kansarka awoodda leh ee bioassays kansarka xayawaanka.

Methylselelenocysteine ​​​​sida darteed waxay faa'iido u leedahay ilaalinta caafimaadka ka hortagga. Doorka difaaca jirka ee selenium si fiican ayaa loo diiwaangeliyay. Intaa waxaa dheer, nafaqo ku filan oo selenium ah ayaa bixisa difaac ka hortagga caabuqyada fayraska iyo cudurrada dabadheeraad sidoo kale. Methylselelenocysteine ​​marka loo eego helitaanka noolaha iyo dhacdooyinka dabiiciga ah ee ilaha cuntada, waa dheeri selenium waxtar leh.

 

Methylselelenocysteine Qiyaasta Kaabayaasha

Methylselelenocysteine ​​​​waa nooc ka firfircoon selenium kaas oo u shaqeeya ugu horreyn sida qayb ka mid ah enzyme antioxidant, glutathione peroxidase. Waxqabadka Glutathione peroxidase, kaas oo u baahan selenium ee dhaqdhaqaaqa, wuxuu fududeeyaa dib-u-warshadaynta fiitamiinada C iyo E, si loo hagaajiyo waxqabadka nidaamka antioxidant. Heerarka hooseeya ee selenium ayaa lala xiriiriyay khatarta sare ee kansarka, cudurrada wadnaha iyo xididada, cudurrada bararka, iyo xaaladaha kale ee la xidhiidha dhaawaca xagjirka bilaashka ah, oo ay ku jiraan gabowga iyo samaynta indhaha. Selenium sidoo kale waxay lagama maarmaan u tahay shaqada difaaca unugyada-dhexdhexaadinta caafimaadka leh, kicinta sifooyinka difaaca ee lymphocytes. Selenium ayaa sidoo kale looga baahan yahay firfircoonida hormoonnada tayroodhka.

Qaadashada selenium ee joogtada ah waxay la xiriirtaa khatarta sii kordheysa ee cudurada wadnaha, kansarka iyo shaqada difaaca ee niyad jabsan. Selenium waxay u muuqataa inay ka hortagto cudurrada wadnaha iyo istaroogga. Kaabidda Selenium (100 ugm/maalintii) waxay kordhisaa saamiga HDL ilaa LDL waxayna joojisaa isku-darka platelet. Selenium iyo glutathione dhaqdhaqaaqa peroxidase ayaa ku yar bukaanada qaba rheumatoid arthritis-ka, cambaarta, psoriasis iyo inta badan xaaladaha bararka. Tani waxay la xiriirtaa kororka kororka ee prostaglandins proinflammatory iyo leukotrienes. Shaqada habka difaaca jirka waxaa xoojisay selenium, iyadoo gacan ka geysata dhaqdhaqaaqa unugga dilaaga dabiiciga ah ee sare (NKC). Unugyada dilaaga dabiiciga ah waxay awood u leeyihiin inay burburiyaan unugyada kansarka iyo wakiilada bakteeriyada iyo fayraska. Calaamadaha sunta biraha culus waxaa laga yaabaa inay yareeyaan selenium, oo u dhaqma sidii antagonist. yaraanta Selenium waxa kale oo laga yaabaa inay gacan ka geysato dhalmo la'aanta ragga.

Selenium waa badbaado heerka guud ahaan loo isticmaalo kabitaanka (100-200 mcg/maalintii). Si kastaba ha ahaatee, qaadashada in ka badan 750 mcg oo selenium ah maalintii waxay keeni kartaa sunta Falcelinta sida luminta cidiyaha faraha, finan maqaarka ah, iyo neerfayaasha. Joogitaanka goiter-ka yaraanta iodine, kabitaannada selenium ayaa la soo sheegay inay uga sii darto shaqada tayroodh hooseeya. Selenium waxaa lagu heli karaa qaabab kala duwan. Cilmi-baaristu waxay tilmaamaysaa in milixyada aan noolaha ahayn sida sodium selenite ay si waxtar yar u nuugaan oo aan u dhaq-dhaqaaqin bayoloji ahaan sida noocyada organic ee selenium, sida selenomethionine ama khamiirka selenium-sare.

 

Methylselelenocysteine ​​​​budada 26046-90-2 Codsiga

Kaabista nafaqada, kaabista cuntada

 

Cuntooyinkee ayaa qani ku ah selenium?

Ilaha ugu wanaagsan ee selenium-ka cuntada waxaa laga helaa:

Jeexitaanka Qamadiga

bran

Brazil Nuts

Red Swiss Chard

Rootida qamadiga oo idil

miro

Brown Rice

Gacmaha

 

Se-Methylselelenocysteine(Methylselelenocysteine) Tijaabo Caafimaad

Lambarka NCT Taageero Xaaladda Ku bilow Date Phase
NCT01611038 Rutgers, Jaamacadda Gobolka New Jersey Kansarka naasaha|Kansarka qanjirka 'prostate' October 2011 Ma khuseyso
NCT01497431 Machadka Kansarka Qaranka (NCI) Ma jiro wax caddayn ah oo cudur ah | Kansarka qanjirka 'prostate' November 2011 1 Phase
NCT04952129 Jaamacadda Auckland, New Zealand | Tijaabooyinka Kansarka New Zealand | Degmooyinka Manukau Health Adenoma Colorectal August 1, 2021 1 Phase

 

Methylselelenocysteine ​​​​budada 26046-90-2 Tixraaca

  1. Kala soocida asiidhyada selenoamino iyo xeryahooda organoselenium ee khamiirka selenium-ka leh iyadoo la adeegsanayo chromatography dareere ah oo waxqabadkiisu sarreeyo
  2. M. Bird, PC Uden, JF Tyson, E. Block, E. Denoyer, J. Anal. Marka Spectrom 1997, 12, 785.
  3. In vitro iyo in vivo ee daraasadaha methylseleninic acid: caddaynta in metabolite selenium monomethylated ay muhiim u tahay ka hortagga kansarka
  4. Ip, HJ Thompson, Z. Zhu, HE Ganther, Kansarka Res. 2000, 60, 2882.
  5. Ellis DR, Sors TG, Brunk DG, Albrecht C, Orser C, Lahner B, Wood KV, Harris HH, Pickering IJ, Salt DE (2004) Wax soo saarka Se-methylselenocysteine ​​ee dhirta transgenic muujinaya selenocysteine ​​methyltransferase. BMC Plant Biol 4:1-11
  6. Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr. khatarta kansarka qanjirka 'prostate'. J Natl Kansarka Inst 2014(106):djt3