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9-Me-BC (2521-07-5)

Budada 9-Methyl-β-carboline (9-Me-BC) waa kiimiko cilmi-baaris ah, oo ah nooca loo yaqaan 'heterocyclic amine'. Sidoo kale loo yaqaan '9-Me-BC', kiimikada waxaa laga yaabaa inay isku dubbarideyso iyadoo la fulinayo ficil-celinta 'Eschweiler - Clarke' ee ku-taal-ka-qabsiga ee beta-carboline. Waqtigaan la joogo, 9-methyl-β-carboline waxaa loo arkaa mid ka mid ah kuwa ugu fiican fasalka-Nootropics, loogu talagalay in lagu gaarsiiyo saameynta wanaagsan ee dheer ee nidaamka dopamine-ka maskaxda. Daraasadihii ugu dambeeyay waxay muujinayaan in budada 9-me-bc ay ku yeelan karto saameyn kiciya maskaxda taasoo laga yaabo inay ka hortagto pathogenesis ee cudurka Parkinson. Kiimikada ayaa waliba laga yaabaa inay gacan ka gaysato kobcinta neuron-ka iyo kobaca neurite, taasoo ka dhigaysa daaweyn rajo leh oo loo isticmaali karo wax ka qabashada ciladaha maskaxda ee xumaanaya. Daraasado kale ayaa sidoo kale muujinaya in 9-me-bc ay sidoo kale maskaxda ka ilaalin karto waxyeelada sunta sidoo kale. Waxa runtii kallifaya 9-methyl-β-carboline kala fog waa dhismayaasha adag ee dopaminergic. Astaamahani waxay si weyn u horumarin karaan dhinacyada kala duwan ee shaqada garashada maskaxda.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

9-Me-BC budada (2521-07-5) fiidiyow

 

9-Me-BC budada (2521-07-5) Xogta Saldhigga

magaca 9-Me-BC / 9-methyl-9H-pyrido [3,4-b] budada indole
CAS 2521-07-5
xagiisayna 98%
Magaca kiimikada 9-Methyl-9H-pyrido [3,4-b] indole
Isku mid ahaanshaha Synonyms9-me-bc;9-Methyl-9H-β-carboline;9-Methyl-9H-beta-carboline;9-methyl-9H-pyrido[3,4-b]indole;9-Me-BC/9-methyl-9H-pyrido[3,4-b]indole;9-Methyl-9H-pyrido[3,4-b]indole
Formula kelli C12H10N2
Miisaanka kelli 182.226 g / mol
Dhibicda Biyaha 105.0 - 109.0 ° C
Muhiimadda InChI MABOIYXDALNSES-UHFFFAOYSA-N
Form Solid
Imaanshaha White Powder
Nolosha badh Lama yaqaan
milmi Lama yaqaan
kaydinta Xaaladda Lama yaqaan
Codsiga 9-Methyl-9H-pyrido [3,4-b] indole (cas # 2521-07-5) waa kiimiko cilmi baaris waxtar leh.
Dukumentiga Tijaabinta Available

 

Waa maxay 9-Methyl-β-Carboline (9-Me-BC)?

Sidii horeyba loogu cadeeyay, 9-Methyl-β-carboline waa kiimiko cilmi baaris oo muujisay inbadan oo guryaha Nootropic ah. Kiimikada waxaa lagu dhex abuuri karaa shaybaarka iyadoo la adeegsanayo falcelinta Eschweiler - Clarke.

Tani waa asal ahaan fal-celin kiimikaad halkaas oo amine asaasi ah lagu methy iyadoo la adeegsanayo xaddi badan oo ah acid formic iyo formdehyde. Marka loo eego qoraallada 9-me-bc ee dib u eegista lagu sameeyay, kiimikadu waa qayb ka mid ah qoyska beta-carboline waxaana loo muujiyey inay leeyihiin awood badan oo dopaminergic ah oo ku jirta daraasadaha kala duwan ee vitro.

Daraasadaha qaarkood ee jiirka, 9-Methyl-β-carboline Waxaa sidoo kale loo muujiyey inuu sare u qaado heerarka sare ee cudurka loo yaqaan 'hippocampal dopamine'. Tani waxay u horseeday inay sii wanaajiso waxqabadka barashada xuruufta by jiirka imtixaanka ee tijaabada galmada. Runtii tani waa sababta ugu weyn ee loo arko 9-Methyl-carbo-ካርline in loo arko inay tahay Nootropic wax ku ool ah.

Laakiin intaas oo keliya ma aha. Daraasadaha qaarkood waxay sidoo kale muujiyeen in 9-Methyl-β-carboline ay kicin karto dib u soo celinta tamarta 'tyrosine hydroxylase' oo muujineysa neurons-ka kaas oo laga yaabo inuu gacan ka geysan karo kahortaga cudurka 'pathogenesis' ee ciladaha maskaxda sida Parkinson.

 

Sidee buu u shaqeeyaa 9-Methyl-β-Carboline?

Maaddaama 9-Methyl-β-carboline ay tahay kiimiko tijaabo ah, waxaa jira macluumaad aad u yar oo halkaas ka jira oo ku saabsan sida ay u shaqeyso. Waxa kaliya ee aan ognahay waa xaqiiqada ah in badeecadu ay leedahay guryo Nootropic ah iyo xoogaa xoog leh oo xoogsaar u leh dhiirrigelinta dopaminergic. Laakiin habka ficil ee kiimikada loo yaqaan wali ma cadda. Waxaa kale oo muhiim ah in la ogaado in aysan jirin daraasado bini-aadam ah oo dhab ah oo ku saabsan saameynta 9-Methyl-β-carboline.

Illaa iyo hadda, baarayaashu waxay sameeyeen daraasado vitro. Kuwani aasaas ahaan waa tijaabooyin tijaabo ah oo lagu sameeyo moleekulada noolaha ee jidhka ka baxsan. Waxaan sidoo kale aragnay daraasado jireed iyo sidoo kale waxaan eegney sida 9-Methyl-carbo-carboline u saameeyso shaqada maskaxda. Ilaa iyo hadda daraasadahaani waxay muujinayaan ballanqaad badan. Daraasadaha jiirka, gaar ahaan, cilmi-baaristu waxay muujineysaa in soo-saarista 9-Methyl-β-carboline ay kicin karto heerarka dopamine-ka ee kor u kaca ee loo yaqaan 'hippocampus', taa oo horseed u ah hagaajinta barashada iyo xusuusta ka dhex jirta jiirka ka qeybqaadanaya daraasadda.

Rajada hadda waa inaan bilowno inaan aragno daraasadaha ku saleysan aadanaha mustaqbalka dhow. Laakiin illaa markaa, way adagtahay in si buuxda loo fahmo farsamooyinka shaqada ee 9-Methyl-β-carboline iyo nooca saamaynta ay ku yeelan karto maskaxda.

 

9-Methyl-β-Carboline (9-Me-BC) Faa'iidooyinka / Saamaynta

9-Methyl-β-carboline waxaa ku yimaada faa iidooyin badan. Waxa jira suurtagal in kiimikada loo adeegsan karo xal ka hortag ah oo ku saabsan ciladaha maskaxda ee xumaanaya laakiin daraasad ku saabsan taas ayaa wali socota.

Si kastaba ha noqotee, halkan waxaa ku yaal qaar ka mid ah saamaynta iyo faa'iidooyinka 9-me-bc caan ah:

  • Daraasadaha qaarkood waxay muujinayaan in 9-Methyl-β-carboline laga yaabo inay kiciso wax soo saarka dopamine ee hippocampus. Tani waxay keeni kartaa wanaajiyay barashada iyo kartida garashada. Tijaabooyinka caafimaad ee jiirarka ayaa muujiyey in maaddooyinka imtixaanku ay awood u yeesheen inay diiwaangeliyaan horumar aad u weyn xagga barashada meelaynta ka dib markii lagu daweeyey 9-Methyl-β-carboline.
  • Waxa kale oo jira daraasado muujinaya muujinta horudhaca 9-Methyl-β-carboline waxay kordhin kartaa heerka neurotrophins lagu soo saaro maskaxda. Heerarka kordhay ee neurotrophins ayaa la ogaaday kor u qaado xusuusta guud iyo barashada inta badan bukaanada.
  • Waxaan sidoo kale aragnay qaar ka mid ah daraasadaha 'vitro' oo soo jeedinaya in 9-Methyl-β-carboline laga yaabo dhab ahaan loo istcimaali karo ka-hortagga cudurada ku dhaca cudurka Parkinson. Laakiin sida ay tani u shaqeyso ayaan weli caddeyn. Waxaa kale oo jirta in 9-Methyl-β-carboline sidoo kale loo adeegsan karo daawo kahortag suurtagal ah mustaqbalka wax ka qabashada arrimaha maskaxda ee xumaanaya. Tani waa sababta oo ah kiimikadu waxay leedahay sifooyin qaarkood oo yareyn kara sunta lipopolysaccharide ee maskaxda ku jirta.
  • 9-Methyl-β-carboline ayaa sidoo kale kicin kara wax soo saarka ATP ama Adenosine Triphosphate ee maskaxda. Tani waxay keeni kartaa hawlaha garashada ee ka weyn bukaanka.

 

9-Methyl-β-Carboline (9-Me-BC) Qiyaasta

Maaddaama aysan jirin daraasado bini-aadamnimo illaa iyo hadda isticmaalka 9-Methyl-β-carboline, hoos u dhigidda qiyaasta saxda ah ma ahan wax fudud. Si kastaba ha noqotee, soosaarayaasha sheygan ayaa ku talinaya qiyaasta 15mg maalin kasta dadka waaweyn.

Tani waxay u tarjumaysaa hal kabasho maalintii, oo ay tahay in la qaado subaxa hore. 9-Methyl-β-ካርline waxaa afka laga siiyaa. Haddii aad durba ku jirtid dawooyin kale, kala tasho dhaqtarkaaga kahor intaadan isticmaalin daawada. Si kastaba ha noqotee, macluumaadka ku saabsan 9-me-bc badh-nolosha ma ahan mid cad.

 

9-Methyl-β-Carboline (9-Me-BC) Saamaynta Dhinacyada

In yar ayaa laga ogyahay dhibaatooyinka suurtagalka ah ee ka imaan kara 9-Methyl-β-carboline. Si kastaba ha noqotee, tan waxaa loo tixgeliyaa inay tahay daawo aamin ah oo aamin ah oo la istcimaalo ilaa intaad kujirto qiyaasta daawada. Hal shay oo maskaxda lagu hayo in kastoo ay tahay suurtagalnimada dopamine neurotoxicity.

Sidaad ogtahay, 9-Methyl-β-carboline waxay kicineysaa soo saarida heerar sare ee dopamine maskaxda. Haddii heerarkan ay aad u sarreeyaan, waxaa jirta halis ay saameyn ku yeelan karaan howlaha mitochondrial. Laakiin tani waa wax aad dhif u ah waana inaysanna dhibaato ku noqon dadka isticmaala qiyaasta saxda ah.

 

9-Methyl-β-Carboline (9-Me-BC) Soo iibso budada

9-me-bc nootropic waxaa loo iibsan karaa sida budo onlayn ah. Waxaa jira dhowr iibiyeyaal ah oo maalmahan wata alaabada laakiin dhammaantood ma aha kuwo ku dhawaad ​​sidii la isku halleyn karo oo aad jeclaan lahayd inay noqdaan. Had iyo goor way fiican tahay in taxaddar dheeraad ah la sameeyo oo keliya si loo hubiyo inaad ka iibsaneyso ilaha saxda ah. Hal shay oo aad sameyn karto ayaa ah inaad hubiso inaad ka iibsaneyso iibiyayaal khibrad u leh tan.

Fiiri dib u eegista sidoo kale, iibiyaasha taariikh u leh soo gudbinta tayada macaamiisha aad u wanaagsan ayaa si weyn lagula talinayaa. Sidoo kale ha iloobin in jaban ay qaali noqon karto. In kasta oo Methyl-carbo-carboline aysan ahayn wax qaali ah, waxaad weli u baahan tahay inaad kubixiso qadar macquul ah si aad u hesho. Laakiin way u qalantaa.

 

9-Me-BC budada (2521-07-5) Tixraac

  1. Polanski, W; Enzensperger, C; Reichmann, H; Gille, G (2010). "Waxyaabaha gaarka ah ee 9-methyl-beta-carboline: kicinta, ilaalinta iyo dib u soo nooleynta dareemayaasha dopaminergic oo ay weheliso saameyn kahortagga bararka". J Neurochem. 113 (6): 1659– doi: 10.1111 / j.1471-4159.2010.06725.x. PMID 20374418.
  2. Hamann, J; Wernicke, C; Lehmann, J; Reichmann, H; Rommelspacher, H; Gille, G (2008). "9-Methyl-beta-carboline up-wuxuu xakameynayaa muuqaalka kala-duwanaanta dopaminergic neurones ee dhaqanka aasaasiga ah ee mesencephalic". Neurochem. Int. 52 (4-5): 688– doi: 10.1016 / j.neuint.2007.08.018. PMID 17913302.
  3. Herraiz, T; Guillén, H (2011). "Ka hortagga bioactivation ee neurotoxin MPTP ee antioxidants, wakiilada redox iyo monoamine oxidase inhibitors". Chem Cuntada. Toxicol. 49 (8): 1773– doi: 10.1016 / j.fct.2011.04.026. hdl: 10261/63126. PMID 21554916.

 

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