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Iibso Nicotinamide Riboside Chloride (23111-00-4) hplc≥98% - Wisdompowder

Budada Nikotinamide Riboside Chloride (23111-00-4)

Budada Nikotinamide Riboside Chloride, oo sidoo kale loo yaqaan NR iyo SRT647, waa qaab loo yaqaan "Pyridine-nucleoside" ee fitamiin B3 kaasoo u shaqeynaya hor udhaca nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka xididka 'ganglion neerons neurons ex vivo' wuxuuna ka ilaaliyaa maqalka dhawaqa maqal ee jiirarka nool. Nicotinamide riboside waxay ka hortageysaa muruqyada, neural iyo melanocyte stem cell senescence. Dib-u-cusboonaysiinta muruqyada jiirarka ayaa la arkay ka dib markii lagu daaweeyay nicotinamide riboside, taasoo horseedaysa la isla dhexmarayo inay hagaajin karto dib-u-cusboonaysiinta xubnaha sida beerka, kelyaha, iyo wadnaha. Nicotinamide riboside sidoo kale waxay hoos u dhigtaa gulukooska dhiigga iyo beerka dufanka leh ee moodooyinka cudurka macaan iyo nooca 2 ee sonkorowga iyadoo laga hortagayo horumarka cudurka maskaxda ee maskaxda ee ku dhaca dareemayaasha. Xusuusin: Nikotinamide Riboside chloride waa isku dhaf α / β

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Fiidiyowga budada ah ee Nikotinamide Riboside Chloride

 

Budada Nicotinamide Riboside Chloride (23111-00-4) Macluumaadka Saldhigga

magaca Budada Nikotinamide Riboside Chloride
CAS 23111-00-4
xagiisayna 98%
Magaca kiimikada 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Isku mid ahaanshaha Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nikotinamide Riboside Triflate, α / β isku dar
Formula kelli C11H15ClN2O5
Miisaanka kelli 290.7 g / mol
Dhibicda Biyaha 115 ℃-125 ℃
Muhiimadda InChI YAABIFCKURFRPPO-FSDYPCQHSA-N
Form Solid
Imaanshaha Ka-qaad Caddaan si aad uhesho budada Jaalaha ah
Nolosha badh saacadood 2.7
milmi Dajinta DMSO
kaydinta Xaaladda Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado).
Codsiga Nicotinamide riboside waa qaab pyridine-nucleoside oo fitamiin B3 ah
Dukumentiga Tijaabinta Available

 

Budada Nicotinamide Riboside Chloride (23111-00-4) Faahfaahin guud

Nicotinamide Riboside Chloride budada nucleosides waa horudhaca nicotinamide adenine dinucleotide (NAD) waxayna matalaan ilaha fitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddar badan oo ah nicotinamide nucleosides si dabiici ah ugu jira cuntooyinka ay ku siin karaan faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nikotinamide nucleosides waxaa lagu soo koobay kordhinta nudaha unugyada 'NAD' iyo soosaarida xasaasiyadda insulin iyo sidoo kale xoojinta shaqada sirtuin. Awoodda ay u leedahay inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides ay sidoo kale hagaajin karto caafimaadka mitochondrial, kicin karto shaqada mitochondrial, ayna soo saari karto wax soo saarka mitochondria cusub. Daraasado kale oo loo adeegsado nikotinamide nucleosides oo ku jira qaabka cudurka Alzheimers ayaa muujiyay in mecuulku yahay mid bioavailable laga heli karo maskaxda oo laga yaabo inuu ku siiyo neuroprotection adoo kicinaya maskaxda isku-darka NAD.

 

Nikotinamide Riboside Chloride History

Daraasadda 2012-kii waxay ogaatay in jiirarku ay quudin jireen dufan aad u tiro badan oo lagu kabo nicotinamide nucleosides waxay lahayd 60% dhimis korodh ah marka loo eego jiirarka ay siisay isla dufan aad u tiro badan oo aan lahayn nicotinamide nucleoside.

Maaddaama antibiyootikada anthracycline, doxorubicin waa mid ka mid ah kuwa ugu waxtarka badan uguna ballaaran ee loo isticmaalo daawooyinka kiimikada ee daaweynta noocyada kala duwan ee burooyinka adag. Nasiib darrose, muddo tobanaan sano ah, wadno-qabatinka ay ku leedahay daaweynta kansarka ayaa xaddiday isticmaalka daawada Daawada.

 

Nidaamka 'Nicotinamide Riboside Chloride Mechanism Of Action'

Nicotinamide Riboside (NR) waa qaab dhowaan laga helay fitamiin B3 kaasoo kordhin kara heerarka heerarka Nicotinamide Adenine Dinucleotide (NAD +) aadanaha.

NAD + waa co-enzyme fure u ah in mitochondria ee unug kasta oo kamid ah jirkeena ay ku tiirsan yihiin shidaalka dhamaan howlaha aasaasiga ah.

Heerarka NAD + ayaa hoos u dhaca marka aynu sii jirno iyo marka jirkeenu uu murugsan yahay cudur ama caabuq raaga.

Niacinamide waa maadada 'coenzyme I' iyo 'coenzyme II', oo noqota coenzyme ee fuuq-baxa badan.

Ka baaraandegga cuntada, nicotinamide waxaa loo isticmaalaa Vc midab hore

Niacin waxaa sidoo kale loo yaqaan fitamiin B3, ama fiitamiin PP, Niacin waxaa sidoo kale loo yaqaanaa nicotinic acid iyo niacin. Jirka bini’aadamka wuxuu kaloo kujiraa nicotinamide nicotinamide ama nicotinamide. Waa mid ka mid ah 13-ka fiitamiin ee loogu talagalay jirka bini’aadamka, waa fiitamiin biyo lagu millo, waxaa iska leh qoyska B ee fiitamiin B. Nikotinic acid oo loo badalay niacinamide, nicotinamide coenzyme iyo qeyb ka mid ah coenzyme, waxay ka qeyb qaadataa dheef-shiid kiimikaadka lipids iyo unugyada Neefta neefsiga ee geeddi-socodka oxidation iyo geedi socodka sonkorta giirte anaerobic.

 

Codsiga loo yaqaan 'Nikotinamide Riboside Chloride Application'

Daraasadaha horudhaca ah waxay muujiyeen in ku darista nikotiinka loo yaqaan 'nicotinamide ribose' aysan kaliya kordhin karin heerarka NAD +, laakiin sidoo kale ay kor u qaaddo isticmaalka NAD + ee aadanaha, taas oo aan suurtagal ahayn marka la qaato fiitamiinnada kale ee B3.Studies ayaa muujisay in mar nicotinamide ribose ay ka muuqato unugga, jirku si dhakhso ah ayuu ugu beddelaa NAD +. NAD + ka dib waxay kiciyaan geedi socodka horudhaca intracellular ee soosaarka tamarta by mitochondria

Nicotinamide Riboside Chloride wuxuu kor u qaadi karaa shaqada mitokondrial, taas oo lagu muujiyey inay kor u qaadeyso muujinta borotiinnada silsiladda gaadiidka elektaroonigga mitirka, kor u qaadista awoodda xuubka mitochondrial, iyo kordhinta heerka neefsiga oksida iyo heerarka ATP intracellular. Tan waxaa la socon kara heerar sare oo ah dib -u -dhalashada mitokondrial. Shaqada mitokondrial ayaa hoos u dhacda marka aan sii gabowno, tanina waa astaanta gabowga unugyada asliga ah ee aan helno. NR waxay kor u qaadi kartaa shaqada mitokondria iyo horjoogsado senescence -ka unugyada asliga ah.

 

Cilmi-baaris Nikotinamide Riboside Chloride

Nikotinamide nucleosides waa horudhaca nicotinamide adenine dinucleotide (NAD) waxayna matalaan isha fitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddarka badan ee nicotinamide nucleosides si dabiici ah looga helo cuntooyinka ay bixin karto faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nicotinamide nucleosides waxaa lagu cabiray kordhinta unugyada NAD iyo soo saarida xasaasiga insulin iyo sidoo kale kor u qaadida shaqada sirtuin. Awoodeeda ah inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides ay sidoo kale hagaajin karto caafimaadka mitochondrial, waxay kicin kartaa shaqada mitochondrial, waxayna kicineysaa soosaarka mitochondria cusub. Daraasado kale oo la isticmaalay nicotinamide nucleosides ee cudurka cudurka Alzheimer ayaa muujisay in molikalku u fiican yahay maskaxda isla markaana ay ku siin karto neuroprotection iyadoo la kicinayo maskaxda NAD.

Nicotinamide Riboside Chloride sidoo kale waxay yareyn kartaa miisaanka: Daraasaduhu waxay muujiyeen in adoo kordhiya dheef-shiid kiimikaadka, aad si wax ku ool ah u yareyn karto cunnada dufanka badan ee culeyskiisu kordho. Si loo qiimeeyo habka loo yaqaan 'nicotinamide ribose' ee NR ee kor u qaadista miisaanka, cilmi baarayaashu waxay qiyaaseen shaqada mitochondrial beerka ee la xiriirta qaadashada kalooriga, firfircoonida, kalooriyada, wareega dhexda, nasashada sicirka dheef-shiid kiimikaadka, isku-dhafka jirka, dulqaadka gulukooska, xasaasiyadda insulin iyo biochemical iyo metabolomics kala duwan. xuduudaha Xogtaan iyo habka miisaanka luminta cusub ee malabsorption, soo saarista astaamaha bayoolojiga si loola socdo. Cilmi baarayaashu waxay soo sheegeen in jiirka la quudin jiray nicotinamide nicotinamide supplements ay aad ugu dhowdahay inuu lumiyo miisaankiisa marka loo eego jiirka aan ku darin nicotinamide

 

Tixraaca Nikotinamide Riboside Chloride

  • Chi Y, Sauve AA. Nikotinamide riboside, oo ah raad nafaqo ku leh cuntooyinka, waa fiitamiin B3 oo saameyn ku leh dheef-shiid kiimikaadka iyo neuroprotection. Daryeelka Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Dib u eegis PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, iyo nicotinamide riboside: qiimeynta molikalikada ee NAD + fiitamiinnada hormarsan ee nafaqada aadanaha. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dib u eegis PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation oo ah unug-intrinsic ah, darawalka korniinka ee keydinta dufanka: kiimikada iyo caqliga dheef-shiid kiimikaadka isbeddelada acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Noof-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dib u eegis PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Yang Y, Sauve AA. NAD (+) dheef-shiid kiimikaad: bioenergetics, calaamad iyo kadhigis ku daaweynta. Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. doi: 10.1016 / j.bbapap.2016.06.014. Dib u eegis PubMed PMID: 27374990.
  • Tilmaamaha Kuufiyeyaasha ee ugu fiican ee loo yaqaan 'Nootropic Stack Guide': Wax kasta oo aad u Baahan Tahay Inaad Ogaato
  • Waxkasta oo aad u Baahan Tahay Inaad Ka Ogaato Nikotinamide Riboside Chloride

 

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