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Budada Dihexa (PNB-0408) budada (1401708-83-5)

Budada Dihexa (PNB-0408) waa daawo Oligopeptide, laga yaabee xitaa hexanediol. Oligopeptide-ka mararka qaar loo yaqaan kaliya peptide, waa dawo ka kooban daraasiin acids amino ah. Caadi ahaan, Oligopeptide wuxuu yeelan karaa meelkasta oo udhaxeeya laba ilaa labaatan amino acids amino. Dihexa waxaa sidoo kale loo yaqaannaa PNB - 0408. Kani wuxuu ahaa magaca koodhka loo isticmaalay marxaladihi hore ee horumarkiisa. Dihexa waxaa loogu talagalay in lagu xidho HGF. Daraasadda hadda la sameeyay waxay muujisay in Dihexa loo isticmaali karo in si weyn looga caawiyo shaqada garashada. Tijaabooyin lagu sameeyay moodellada xayawaanka oo qaba cilladaha maskaxda ee Alzheimer waxay muujiyeen ballanqaadyo badan oo ah isticmaalka Dihexa sida ugu macquulsan ee daaweynta. Ka sokow, adeegsiga Dihexa wax dhibaato ah uma geysan doono sinaba. Bukaanka badankood ee kaqaybqaatay tijaabooyinka ma soo sheegin wax sun ah. Dihexa waxaa inta badan loo tixgeliyaa inay tahay dawada Nootropic ee awoodda leh. Waxaa soo saaray cilmi baarayaal ka tirsan Jaamacadda Gobolka Washington. Markii hore, daroogada waxaa loo arkay inay tahay ikhtiyaar daawayn oo suurtagal ah oo loogu talagalay ciladaha maskaxda ku saleysan. Si kastaba ha noqotee, waxay heshay dalabyo dheeri ah oo ku saabsan hagaajinta shaqooyinka garashada qaarkood iyo sidoo kale ay ka mid yihiin xaaladaha neurodegenerative sida Alzheimer.

Soo-saar: Soosaaris Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.

Dihexa (PNB-0408) budada (1401708-83-5) fiidiyaha

 

Dihexa (PNB-0408) Budada Macluumaadka Saldhigga

magaca Budada Dihexa / PNB-0408
CAS 1401708-83-5
xagiisayna 98%
Magaca kiimikada 6-[(2S,3S)-2-[(2S)-2-hexanamido-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]hexanamide
Isku mid ahaanshaha PNB-0408; PNB 0408; PNB0408; Dihexa; N-hexanoic-Tyr-Ile- (6) aminohexanoic amide; N- (1-Oxohexyl) -L-tyrosyl-N- (6-amino-6-oxohexyl) -L-isoleucinamide
Formula kelli C27H44N4O5
Miisaanka kelli  504.672
Dhibicda Biyaha > 209 ° C (dec.)
Muhiimadda InChI XEUVNVNAVKZSPT-JTJYXVOQSA-N
Form Dufanka adag
Imaanshaha White to White-White Solid
Nolosha badh Lama yaqaan
milmi DMSO (Hoos Joog), Methanol (Gaar ah)
kaydinta Xaaladda Hygroscopic, Qaboojiye, oo ku jira jawiga firfircoon
Codsiga N-Hexanoic-Try-Ile- (6) -amino Hexanoic amide (Dihexa) waa analogensin IV analog oo loo yaqaan 'procognitive / antidementia wakiil'.
Dukumentiga Tijaabinta Available

 

Waa maxay budada Dihexa?

Sidaan horeyba kor ugu soo sheegnay guud ahaan, Dihexa (PNB-0408) budada waa daawada Oligopeptide oo ka kooban lix amino acids. Daawada waxaa lagu soo saaray Jaamacadda Washington State University waxaana si toos ah looga soo qaatay angiotensin IV. In kasta oo jidhka bini’aadamka uu leeyahay wax soo saarkiisa Oligopeptide, mararka qaar xaddiga la soo saaray kuma filna.

Kordhintu sidaa darteed aad ayey muhiim u tahay oo budada Dihexa, oo la soo saaray laguna iibiyo khadka tooska ah, ayaa kaa caawin kara. Dihexa sidoo kale waa dawo Nootropic aad u awood badan. Waxaa loo suuq geeyay sidii daaweyn macquul ah oo loogu talagalay cilladaha garashada ee kala duwan. Waxay kaa caawin kartaa hagaajinta xusuusta iyo kobcinta guud ahaan shaqada maskaxda ee dadka da'da yar iyo kuwa da'da ah. Dhowr cilmi baarayaal ayaa si gaar ah farta ugu fiiqay awoodda sii kordheysa ee Dihexa oo ah daaweyn xoog leh oo loogu talagalay cudurrada maskaxda ee neurodegenerative sida cudurka Alzheimers.

Waxa ka soocaya Dihexa waa awooddeeda. Hal qoraal oo sharraxaya waxqabadka Nootropic ee maskaxda bini-aadamka, cilmi-baarayaashu waxay ogaadeen in Dihexa uu noqon karo milyan jeer ka awood badan Brain-Derured Nootropic Factor ama BDNF. Si si fudud loo dhigo, haddii aad isticmaaleyso Dihexa markaa waxaad u baahan tahay inaad diyaar u ahaato saamaynta degdega ah ee awooda leh.

 

Sidee bay budada Dihexa u shaqaysaa?

Dihexa waa daawo Oligopeptide ah oo u shaqeysa sidii analog dhiig-maskaxeed angiotensin IV. Ma jiraan macluumaad badan oo faahfaahsan oo ku saabsan qaabka waxqabadka Dihexa. Laakiin waxaan ognahay in daroogadu ay ku xidhan tahay Xaaladda Kobaca Hepatocyte (HGF) oo leh xidhiidh aad u sarreeya. HGF waa mid ka mid ah waxyaabaha ugu muhiimsan koritaanka jirka. Waxay mas'uul ka tahay nidaaminta koritaanka unugyada, dib-u-cusbooneysiinta unugyada, iyo dhaqdhaqaaqa dhammaan qaybaha jirka bini'aadamka oo ay ku jirto maskaxda.

Kani waa mid ka mid ah sababaha loo arko Dihexa inuu yahay kicinta suurtogalka ah ee caawinta dib-u-cusboonaysiinta maskaxda. Qaar ka mid ah daraasadihii ugu dambeeyay ayaa muujinaya in Dihexa ay soo bandhigtay waxqabadka anti-waallida oo aad u wanaagsan. Daawada waxay sidoo kale kaa caawin doontaa hagaajinta shaqooyinka garashada sidoo kale. Si kastaba ha noqotee, daraasadahan badankood waxaa lagu sameeyay moodello xayawaan. Intaa waxaa sii dheer, waxay sidoo kale suurta gal u tahay Dihexa inuu kadhigto lafdhabarta laf-dhabarka. Dhamaan howlahaani waxay muhiim u yihiin horumarka maskaxda ee caafimaadka qaba. Nolosha badhkeed ee Dihexa wali si cad uma muuqato hadda laakiin waxaad ka heli kartaa macluumaad dheeraad ah dhakhtarkaaga.

 

Faa'iidooyinka budada Dihexa iyo Isticmaalka

Dihexa dihexagonal dipyramidal waa dawo xoogaa cusub hadana in kasta oo ay jiraan xoogaa cilmi baaris ah oo ku saabsan halkaa, waxaa jira macluumaad badan oo aanan aqoon. In kasta oo adeegsiyo badan oo Dihexa jira, haddana dawadan waxaa loo sameeyay si looga caawiyo daweynta jahawareerka. Asal ahaan, daroogada waxaa loo dallacsiiyay inay tahay awood weyn oo Nootropic ah oo loogu talagalay dadka qaba cudurka Alzheimer.

Si kastaba ha noqotee, Dihexa wuu ka duwan yahay qaar ka mid ah dawooyinka Alzheimers ee caadiga ah ee suuqa. In kasta oo inta badan daawooyinkan ay si fudud uga hortagaan inuu cudurku ka sii daro, Dihexa wuu beddeli karaa waxyeelada keentay. Waxa kale oo jira faa'iidooyin kale oo muhiim ah oo sidoo kale lagu sugi karo sidoo kale Dihexa.

Halkan waxaa ah:

  • Wuxuu kaa caawin karaa xanuunnada maskaxda ee neerfayaasha sida cudurka Parkinson iyo Alzheimer's
  • Waxaa loo isticmaali karaa in lagu dhiirrigeliyo fikirka hal abuurka iyo sare loogu qaado xirfadaha sheekaysiga iyo fahamka. Marka, tixgeli Dihexa iibso maanta.
  • Daawada ayaa sidoo kale laga yaabaa inay ku caawiso wanaajinta barashada diiradda bukaanka sidoo kale
  • Dihexazina waxaa laga yaabaa inay kaa caawiso hagaajinta tamarta maskaxda iyo adkeysiga
  • Dihexa dopamine waxaa loo isticmaali karaa in lagu hagaajiyo xirfadaha xallinta dhibaatooyinka, gaar ahaan bukaannada da'da yar ee qaba dhibaatooyinka la xiriira feejignaanta.
  • Peptide -ka Dihexa ayaa sidoo kale laga yaabaa in loo isticmaalo maaree diiqadda. Waxay kaloo caawin kartaa yaree walaaca sidoo kale.
  • Daraasadaha qaar ayaa sidoo kale soo jeedinaya in Dihexa laga yaabo inuu hagaajiyo caafimaadka wadnaha. Waxaan sidoo kale aragnay dad kale oo sheeganaya in dawada ay horumarin karto guud ahaan caafimaadka timaha.

In kasta oo ay jiraan faa'iidooyinkan la yaabka leh, waxaa muhiim ah in la ogaado in dhammaan sheegashooyinka aan lagu caddeyn baaritaan caafimaad oo ballaaran. Qaarkood waxay ku saleysan yihiin fahamka aragtida sida Dihexa u shaqeyso iyo dib u eegista isticmaaleyaashii hore. Laakiin waxaa jira hal shay oo aan hubno. Dihexa aad buu u shaqayn doonaa sida a dheeraadka kobcinta garashada.

 

Sidee loo isticmaalaa budada Dihexa?

Haddii aadan hubin Dihexa sida loo isticmaalo, waan ku caawin karnaa. Dihexa waa dheeri Nootropic ah. Tan micnaheedu waa in lagu duraa afka oo loo maro marinka dhiigga iyada oo loo maro nidaamka caloosha. Si kastaba ha noqotee, waxaa jira macluumaad aad u yar oo ku saabsan qaadashada. Si kastaba ha noqotee, maadaama ay tani tahay Nootropic awood leh, waxaa laga yaabaa inay fikrad fiican tahay inaad la hadasho takhtarkaaga oo aad aragto haddii ay kugula talin karaan qiyaasta kugu habboon.

Ha u isticmaalin Dihexa sare ama Nootropic kale haddii aad qaadatid dawooyin kale. Dihexa sidoo kale waa inaysan u adeegsan haweenka uurka leh ama dadka qaba cudurada daba-dheeraada ilaa ay kala tashadaan inuu sidaas sameeyo xirfad-yaqaan caafimaad.

 

Dihexa (PNB-0408) Ogeysiiska budada

Tan iyo markii ay billowday horumarinteeda, Dihexa wuxuu awoodey inuu sameeyo dhowr meelood oo muhiim ah, dhowr sano ka hor, tusaale ahaan, dawada waxay muujisay ballanqaad badan oo ku saabsan daaweynta Alzheimer ka dib markii ay gacan ka geysatay dib u dhiska unugyada maskaxda ee cusub ee bukaannada dhexdooda. Tani waxay muhiim ahayd hal sabab. Waxaad arkaysaa dawooyin badan oo jahawareer ah oo halkaa ka jira oo si fudud uga caawiya joojinta ama hoos u dhigida hannaanka xumaanta ee sababa xanuunka. Markii dib loo cusbooneysiinayo xiriirrada cusub ee unugyada maskaxda, Dihexa wuxuu muujiyey in dawadu gacan ka geysan karto dib u soo celinta waxyeelada waallida. Dihexa 2019 ayaa sidoo kale lagu sharxay inuu yahay shey-soo-jiidasho ku sameysa qoraalo waaweyn sababta oo ah saamaynta awoodda Nootropic.

 

Dihexa (PNB-0408) ee Iibka

Haddii ay dhacdo inaad dareento in Dihexa uu wax badan kuu tari karo, ka dib waxaad ku iibsan kartaa khadka tooska ah. Waxaa jira dhowr iibiyeyaal oo halkaas ka bixiya soo bandhigaya sheyga. Dihexa waxaa lagu iibiyaa qaddiyado kala duwan. Haddii aad raadinayso 2 mg oo fudud ama qiyaas dhan 500 mg, waxaad heli doontaa iibiyayaal diyaar u ah inay bixiyaan runtii waxaad raadineysay. Laakiin intaadan qofna ka iibsan kaabista, iska hubi inay hayaan shey dhab ah.

Dad badan oo 'Nootropics' ah ayaa suuqa ka jira hadda. Laakiin waad ka faa'iidaysan kartaa oo keliya haddii aad iibsato badeecad run ah. Iibiyaasha la aaminay ee leh rikoodh la hubo oo ku saabsan soo bandhigida alaabada tayada leh waa inay kujiraan liiskaaga Fiiri dib-u-eegista isticmaaleyaasha kale bogagga sida Reddit oo ka hel talo-bixin dhaqtarkaaga oo ku saabsan meesha laga iibsado. Waxay kaloo noqon kartaa fikrad fiican inaad ku isticmaasho lacag yar oo dheeraad ah tayada. Inkasta oo aanu kugu dhiirigelinayn inaad bixiso lacag aad u badan Dihexa, haddii aad rabto dheeri tayo leh oo la isku halleyn karo, taas kumaba noqon doonto mid jaban.

 

Dihexa (PNB-0408) Tixraac

  • Benoist CC, et al. Saamaynta cilmi-baarista iyo saamaynta synaptogenic ee peptides-ka angiotensin IV waxay kuxirantahay firfircoonaanta nidaamka koritaanka hepatocyte / c-met system. J Pharmacol Exp Ther. 2014 Nov; 351 (2): 390-402
  • Mathapati S, Siller R, Impellizzeri AA, Lycke M, Vegheim K, Almaas R, Sullivan GJ. Hepatocyte-Molecule-Directed Hepatocyte-Sida unugyada Unugyada Aasaasiga ah ee Unugyada Aadanaha. Curr Protoc Stem Cell Biol. 2016 Agoosto 17; 38: 1G.6.1-1G.6.18. doi: 10.1002 / cpsc.13. PubMed PMID: 27532814.
  • Siller R, Greenhough S, Naumovska E, Sullivan GJ. Kala soocidda hepatocyte-ka-yar-yar-yar ee unugyada asliga ee unugyada jirka aadanaha. Warbixinta unugyada asliga ah 2015 Meey 12; 4 (5): 939-52. doi: 10.1016 / j.stemcr.2015.04.001. PubMed PMID: 25937370; PubMed Central PMCID: PMC4437467.

 

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