Alaabta
Budada Coluracetam (135463-81-9)
Budada Coluracetam (135463-81-9) fiidiyaha
Macluumaadka Saldhigga budada ee Coluracetam
| magaca | Budada Coluracetam |
| CAS | 135463-81-9 |
| xagiisayna | 98% |
| Magaca kiimikada | N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
MKC-231 bci-540 |
| Isku mid ahaanshaha | Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKC231. |
| Formula kelli | C19H23N3O3 |
| Miisaanka kelli | 341.411 g / mol |
| Dhibicda Biyaha | |
| Muhiimadda InChI | PSPGQHXMUKWNDI-UHFFFAOYSA-N |
| Form | Dufanka adag |
| Imaanshaha | budada crystalline cad |
| Nolosha badh | |
| milmi | Dajinta DMSO |
| kaydinta Xaaladda | Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado) |
| Codsiga | Coluracetam (MKC-231) waa racetam synthetic daroogada loo sheegay inay tahay nootropic xarun. Ma haysto caddayn ballaaran oo caddayn ah oo baaraya, laakiin hababka ficilka (iyo sidoo kale qaab-dhismeedka) waxay u muuqdaan kuwo aad uga duwan xeryahooda kale ee racetam sida Piracetam ama Aniracetam. |
| Dukumentiga Tijaabinta | Available |
Coluracetam budada Qeexida Guud
Budada Coluracetam, oo leh CAS 135463-81-9, waxaa sidoo kale loo yaqaan BCI-540 iyo MKC-231. Coluracetam waxaa laga soo hindisay Japan oo ay markii ugu horreysey iska diwaangashan tahay 2005tii iyada oo ay Mastubishi Tanabe Pharmaceutical Corporation, ka dibna rukhsaddeedii lagu wareejiyay BrainCells Inc.
Budada Coluracetam waa a kabka maskaxda Kor u qaadida garashada, hagaajinta xusuusta iyo sidoo kale waxay daaweysaa xanuunka weyn ee niyad-jabka (MDD) iyo sidoo kale dhibaatooyinka walaaca.
Budada Coluracetam (135463-81-9) Taariikh
Coluracetam (INN) (magaca koodka BCI-540; hore MKC-231) budada waa wakiilka nootropic ee qoyska racetam. Waxaa markii hore soo saaray oo tijaabisay Shirkadda Mitsubishi Tanabe Pharma ee cudurka Alzheimers. Ka dib markii daawadu ay ku guul darreysatay inay gaarto dhammaadka tijaabooyinkeeda caafimaad, waxaa shati u siisay BrainCells Inc si loo baaro xanuunka weyn ee niyad-jabka (MDD), kaas oo ka horreeyay in lagu abaalmariyo deeqda "Barnaamijka Daahfurka Daawaynta u Qalma" ee gobolka California.
Natiijooyinka laga helay wajiga IIa tijaabooyinka caafimaad waxay soo jeediyeen inay noqon karto daawo suurtagal ah oo loogu talagalay comorbid MDD oo leh walaaca guud (GAD). BrainCells Inc hada waa [goormay?] Rukhsad ka siineysaa dawadan ujeeddadan. [Tixraac buuxa ayaa loo baahan yahay] Waxay sidoo kale lahaan kartaa adeegsiga kahortaga iyo daaweynta cudurka isukemic iyo dhaawaca wadnaha iyo indhaha.
Coluracetam ayaa la tusay inuu u weecday soosaarkii choline acetyltransferase ee soosaarka meherada dhexe ee motska ee loo yaqaan 'phencyclidine' (PCP), waxaana loo arkaa inuu yahay dawada daweynta cudurka schizophrenia.
Coluracetam (135463-81-9) Farsamooyinka Ficil
Coluracetam waxay kor u qaadeysaa kor u qaadista choline (HACU), taas oo ah tallaabada xaddidaysa acetylcholine (ACh). Daraasaduhu waxay muujiyeen coluracetam wanaajiyo naafonimada barashada hal qiyaas afka ah oo la siiyay jiirka oo ay soo gaareen cholinergic neurotoxins. Daraasado ku xigay ayaa muujiyey in laga yaabo inay u horseeddo saamayn muddo-dheer ah oo jiirka cholinergic neurotoxin-ka lagu daweeyo iyada oo la beddelo nidaamka qawaaniinta xamuulka qaada.
Faa'iidooyinka Coluracetam (135463-81-9)
Coluracetam waa a nootropic ka kooban qoyska racetam, oo leh saamayn gaar ah kor u qaadida affinity choline sare.
Coluracetam wuu awoodaa hagaajinta xasuusta, barashada, welwelka, niyad-jabka, iyo aragga. Waxay leedahay adeegsi suurtagal ah ka -hortagga iyo daaweynta cudurka 'retinopathy ischemic' iyo dhaawaca dareemayaasha indhaha iyo indhaha. Waxa kale oo ay ku wanaajin kartaa naafonimada barashada hal qiyaas afka ah oo la siiyo jiirka kuwaas oo soo gaadhay cholinergic neurotoxins.
Waxay u horseedi kartaa saameynta garashada dheer ee feeraha cholinergic neurotoxin-daweynta iyadoo la beddelayo nidaamka qawaaniinta gaadiidleyda cholinegic. Coluracetam ayaa sidoo kale la tusay inay wanaajiso awoodda AMPA, taas oo ah geeddi-socod kicin kara shaqeynta garashada iyo feejignaanta.
Coluracetam (135463-81-9) saameyn side
Intaa waxaa dheer, racetam caadiga ah waxyeellooyin sidoo kale waxay khuseeyaan isticmaalayaasha Coluracetam. Dadka qaarkiis waxay la halgamayaan madax-xanuun sababtoo ah la'aanta acetylcholine (oo ay hagaajisay alfa GPC ama citicoline). Dadka kale waxay leeyihiin Colurracetam waxyeellooyin sida kicinta xad dhaafka ah ama xanaaqa, lalabo, ama xanaaqa.
Coluracetam (135463-81-9) Tixraac
- Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, kor u qaadista choline: (3) Qaabka waxqabadka ee MKC-231 ee kor u qaadida isku xirnaanta heerka sare ee choline. J Neural Transm (Vienna). 2008 Jul; 115 (7): 1037-46. doi: 10.1007 / s00702-008-0049-0. PubMed PMID: 18461273.
- Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, kor u qaade kor u qaadista choline-ka: (1) isbadal waarta oo muddo dheer socdey kadib markii lagu soo celceliyey jiirka AF64A-da. J Neural Transm (Vienna). 2008 Jul; 115 (7): 1019-25. doi: 10.1007 / s00702-008-0053-4. PubMed PMID: 18461272.
- Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, kor u qaadista kororka ee choline: (2) Saamaynta isugeynta iyo siideynta acetylcholine ee jiirka AF64A-daweynta. J Neural Transm (Vienna). 2008 Jul; 115 (7): 1027-35. doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.
- Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Soo-jeedinta ku xigta ee kor u qaadista choline-ka MKC-231 waxay ka hortageysaa yaraanta dabeecadda dabeecadda-yaraanta dabeecadda iyo yaraynta septal cholinergic neurons ee jiirka. Eur Neuropsychopharmacol. 2007 Sep; 17 (9): 616-26. PubMed PMID: 17467960.
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