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Iibso budada fosfooraha NSI-189 (1270138-41-4) hplc≥98% - Wisdompowder

Budada fosfateerka NSI-189 (1270138-41-4)

NSI-189 fosfooras waa kiciyaha neerfaha ee neurogenesis ee unugyada asliga ee unugyada asalka ah ee unugyada asalka ah ee unugyada asalka ah ee unugyada asliga ah ee loo yaqaan 'estrogen' unugyada stem neural stem in vitro iyo vivo. Budada loo yaqaan 'Phodishate budada' Raw NSI-189 ayaa sidoo kale loo maleynayaa inay tahay daaweyn balan qaad ah oo loogu talagalay xaalado kale oo ay ka mid yihiin qalalaasaha post-traumatic stress disorder (PTSD), Cudurka Alzheimer iyo dhibaatooyinka la xiriira da'da.

Soo-saar:  Soosaarid Dufcaddii
Xidhmada: 1KG / bac, 25KG / durbaan
Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Nodi-189 fosfooraska budada ah (1270138-41-4) fiidiyow

 

 

Macluumaadka Saldhigga Nuc-189 fosfate Base

magaca NSI-189 fosfate budada
CAS 1270138-41-4
xagiisayna 98%
Magaca kiimikada (2-((3-Methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)-methanone phosphate
Isku mid ahaanshaha NSI189 Fosfate; NSI 189 Fosfate; NSI-189 Fosfate
Formula kelli C22H33N4O5P
Miisaanka kelli 464.5
Dhibicda Biyaha
Muhiimadda InChI LWHMGALTTIYPJU-UHFFFAOYSA-N
Form Powder
Imaanshaha budo cad
Nolosha badh Lama yaqaan
milmi Lama yaqaan
kaydinta Xaaladda Ku keydi 4-8 ° C
Codsiga isticmaalka nootropic
Dukumentiga Tijaabinta Available

 

NSI-189 fosfarihiisa Faahfaahin Guud

NSI-189 phosphate waa neurogenic iyo nootropic wakiilka cilmi-baarista ee laga sameeyay nicotinamide iyo pyrazine.

Tijaabooyin la xakameeyay oo la soo koobay waxay muujiyeen inay kicineyso neurogenesis ama soosaarka unugyada neerfaha maskaxda. Daraasadaha xayawaanka, waxaa sidoo kale lagu muujiyey inay kordhiso mugga loo yaqaan 'hippocampus' 20% taas oo ay dib ugulaabanayso astaamaha dabeecadda niyad-jabka. Daraasadaha noocan oo kale ah waxay muujiyeen inay noqon karto daaweyn wax ku ool ah niyadjabka.

Waxaa sidoo kale loo maleynayaa inay tahay daaweyn rajo leh oo loogu talagalay xaalad kale oo ay ka mid yihiin jahwareerka murugada kadib (PTSD), cudurka Alzheimers iyo dhibaatooyinka la xiriira da'da.

 

NSI-189 fosfooraha Mechanism Of Action

Baarayaasha waxaay ogaadeen in cudurka ugu weyn ee niyad jabku leeyahay (MDD) -i uu hoos udhacayo mugga hippocampal. Ogsoonow in hippocampus caafimaad qaba ay tahay isha ugu wanaagsan unugyada asliga ah ee neerfaha taas oo horseedda soosaarka neerfayaasha. Neurons dhinaca kale waxay muhiim u yihiin sameynta xiriiro cusub oo muhiim u ah maskaxda. Iyada oo loo marayo soo-saarka neurons cusub ee aagga hunguriga, murugada ayaa la daaweyn karaa.

NSI-189 fosfate waxaa loo sameeyay si wax looga qabto seddex arrimood oo muhiim ah oo niyad jab ah oo ay ku jiraan mugga hippocampal, neurogenesis iyo neurotransmission. NSI-189 wuxuu kordhiyaa mugga gudaha hippocampus. Marka sidaas la samaynayo, mugga hippocampal iyo cufnaanta unugyada maskaxda ee caafimaadka qaba ayaa la kordhiyay iyadoo la wanaajinayo habka iyo garashada garashada. Marka laga reebo kordhinta mugga hippocampal, daroogadu waxay sidoo kale hagaajineysaa shaqeynta unugyada neerfaha. Waxay ka shaqeysaa iyada oo kor u qaadeysa koritaanka unugyada neerfaha ee caafimaadka leh iyada oo la dayactirayo meelaha maskaxda waxyeellada ka soo gaadhay.

 

Nodi-189 budada fosfooraska (1270138-41-4) Codsi

  1. Hagaajinta jawaabaha dabeecadda ee la xiriira niyad -jabka.
  2. Dib udhac ku saabsan xasuuqii hunguriga lahaa.
  3. Waxaa laga yaabaa inay kor u qaaddo xusuusta iyo garashada iyada oo loo marayo kororka neerfaha, gaar ahaan maaddooyinka niyadjabsan.
  4. Saameyn wanaagsan ayaa laga yaabaa inay sii socdaan ka dib daaweynta dartiis.

 

Nodi-189 fosfooraska budada ah (1270138-41-4) Daraasad dheeri ah

Daraasado la sameeyay si loo qiimeeyo saameynta NSI-189 fosfate ayaa shaaca ka qaaday in 40 ilaa 80 mg maalin kasta ay waxtar u leedahay daaweynta niyad-jabka iyo calaamadaha garashada ee bukaanada caafimaadka qaba. Tijaabooyinkan, ma jiraan dhacdooyin halis ah oo xun oo la duubay. Guud ahaan, NSI-189 fosfateerka ayaa si wanaagsan loogu dulqaadan karaa oo ammaan u yahay isticmaalka aadanaha.

 

NSI-189 fosfooraha budada Tixraaca

  • 1: Papakostas GI, Johe K, Hand H, Drouillard A, Russo P, Kay G, Kashambwa R, Hoeppner B, Flynn M, Yeung A, Martinson MA, Fava M. Wajiga 2, laba indhoole, daraasad xakameyn ee NSI-189 fosfeti, oo ah xarun neurogenic ah, oo ka dhexeysa bukaan-socodka qaba murugo weyn. Mol Psychiatry. 2019 Jan 9. doi: 10.1038 / s41380-018-0334-8. [Epub ka hor daabacaadda] PubMed PMID: 30626911.
  • 2: Liu Y, Johe K, Sun J, Hao X, Wang Y, Bi X, Baudry M. Kobcinta caloosha synaptik iyo dib-u-noqoshada daciifnimada dhaqdhaqaaqa mooyee iyo howlaha garashada ee moodeelka mooryaanta 'Angelman Syndrome' oo ah unug yar yar oo neurogenic ah, NSI -189. Neuropharmacology. 2019 Jan; 144: 337-344. doi: 10.1016 / j.neuropharm.2018.10.038. Epub 2018 Nov 5. PubMed PMID: 30408487.
  • 3: Allen BD, Acharya MM, Lu C, Giedzinski E, Chmielewski NN, Quach D, Hefferan M, Johe KK, Limoli CL. Dhex-dhexaadinta Feejignaanta Indhaced-ka-Fasaxidda Nidaamka Afka ah ee Maareynta Afka ee Neuroprotective Compound NSI-189. Radiat Res. 2018 Apr; 189 (4): 345-353. doi: 10.1667 / RR14879.1. Epub 2018 Jan 19. PubMed PMID: 29351056; PubMed Central PMCID: PMC5910029.

 

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