Alaabta
Budada Phenethyl Caffeate budada (104594-70-9)
Phenethyl Caffeate budada (104594-70-9) fiidiyaha
Macluumaadka Saldhigga budada ee Phenethyl Caffeate budada
| magaca | Budada caffeate ee Phenethyl |
| CAS | 104594-70-9 |
| xagiisayna | > 98.0% (HPLC) |
| Magaca kiimikada | Caffeic acid phenethyl ester Kafeega Phenethyl 104594-70-9 CAPE Kafeega Phenylethyl |
| Isku mid ahaanshaha | 3- (3,4-Dihydroxyphenyl) -2-propenoic acid phenylethyl ester |
| Formula kelli | C17H16O4 |
| Miisaanka kelli | 284.311 g / mol |
| Dhibicda Biyaha | 127.0-131.0 ° C |
| Muhiimadda InChI | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| Form | Solid |
| Imaanshaha | budo huruud Light |
| Nolosha badh | 21.2 ilaa daqiiqo 26.7 |
| milmi | Dhibaatada DMSO (10 mg / ml), ethanol (100 mM), ethyl acetate (50 mg / ml), methanol, acetone, iyo acetonitrile. Biyo aan lagu dhaqmi karin. |
| kaydinta Xaaladda | -20 ° C |
| Codsiga | Wakiilka Antineoplastic
Walax oo joojiya ama ka hortagaya kororka neoplasms. wakiilka neerfaha Xarun kasta oo loo isticmaali karo daaweynta cudurada neerfayaasha. wakiilka anti-bararka Xarun kasta oo leh saameyn ka hortag ah. difaaca jirka Walax bayooloji ahaan firfircoon oo hawshoodu saamayn ku leedahay ama door ka ciyaaraysa shaqeynta nidaamka difaaca jirka. |
| Dukumentiga Tijaabinta | Available |
Phenethyl Caffeate budada Sharaxa Guud
Phenethyl Caffeate budada (104594-70-9) waa ester alkyl caffeate ester oo 2-phenylethyl ay ka tahay alkyl ka. Waxay leedahay door ah wakiilka antineoplastic, wakiilka anti-bararka, immunomodulator, metabolite, antioxidant, wakiilka neuroprotective, wakiilka antiviral iyo wakiilka antibacterial.
Kafeega Phenethyl budada waa alkolada phenethyl ester ee caffeic acid iyo qayb bioactive ah oo ka mid ah propolis rugta honeybee, oo leh antineoplastic, cytoprotective iyo waxqabadyo immunomodulating. Marka la maamulo, Phenethyl caffeate waxay joojisaa firfircoonida qoraalka nukliyeerka ee NF-kappa B waxayna xakameyn kartaa p70S6K iyo waddooyinka calaamadaynta Akt. Intaa waxaa dheer, Phenethyl caffeate waxay xakameysaa kororka PDGF-ku-kordhinta unugyada muruqyada siman ee xididdada iyada oo loo marayo kicinta p38 mitogen-activated protein kinase (MAPK) iyo hypoxia-inducible factor (HIF) -1alpha iyo soo-saarka xiga ee heme oxygenase-1 (HO-1). ).
Taariikhda budada Phenethyl Caffeate
Kafeega Phenethyl waa iskujir laga helo propolis, isku dar ah ay soo saaraan shinnidu. Kafeega Phenethyl wuxuu soo bandhigayaa anti-bararka, anti-atherosclerotic, antioxidative, cardioprotective, buurnaanta ka hortagga, iyo waxqabadyada daaweynta kiimikada ee lidka ku ah. In vitro, phenethyl caffeate wuxuu xakameynayaa muujinta IL-1β ee IL-6, MCP-1, iyo ICAM-1, wuxuuna xakameynayaa fosforyaalka ah Akt iyo NF-κB. In vivo, phenethyl caffeate wuxuu yareeyaa heerarka AST iyo lactate dehydrogenase wuxuuna xakameynayaa lipid peroxidation.
Farsamaynta Caffeate Phenethyl ee Waxqabadka
Phenethyl caffeate waa qayb ka mid ah propolis ee finan honeybee waxaana la muujiyey inay ku jirto saamaynta xannibaadda ee dhiirigelinta papilloma ee jiirarka. Daraasaduhu waxay muujiyeen in kafeega Phenethyl uu u dhaqmo sida wakiilka ka hortagga faafinta ee koritaanka unugyada wax soo saarka badan. Waxa kale oo la tusay in Phenethyl caffeate ay sababi karto kala-goynta DNA-da iyo apoptosis taasoo keeni karta natiijooyin sun ah oo ku wajahan unugyada embryo fibroblast-ka ee cloned (CREF). Intaa waxaa dheer, unugyadii CREF waxay dhammaysteen unugga gacanta glutathione (GSH) waxay u muuqatay inay aad ugu nugul yihiin dhimashada unugyada kafeega ee Phenethyl.
Kafeega Phenethyl ayaa lagu soo warramey inuu leeyahay anti-carcinogenic, anti-bararka, iyo guryaha difaaca jirka. Kafeega Phenethyl wuxuu kaloo xakameeyaa isku-darka HIV-1. Astaamaha anti-bararka waxaa loo maleynayaa inay sabab u tahay xakamaynta wadada lipoxygenase ee dheef-shiid kiimikaadka arachidonic acid ee Phenethyl caffeate. Daraasaduhu waxay kaloo muujiyeen kafeega Phenethyl inuu noqdo kahortag gaar ah oo karti u leh firfircoonida soo gudbinta cunsuriyadda nukliyeerka NF kappa B, oo ah dhisme ka kooban borotiin oo kontaroolaya qoraalka DNA. Kafeega Phenethyl waa ka hortaga ODC iyo Tyrosine Kinase.
Codsiga Caffeate Phenethyl
Kafeega 'Phenethyl caffeate' sidoo kale wuxuu yareeyaa miisaanka jirka oo kordha iyo dufanka baruurta ee moodooyinka xayawaanka ku quudiya cunno dufanka badan, oo ay suurtogal tahay in laga hortago adipogenesis. Moodooyinka kale ee xayawaanka, xaruntani waxay xaddideysaa 5-lipoxygenase waxayna yareysaa dhiig karka, dhigaal dhigida collagen, iyo biomarkers kale ee atherosclerotic. Moodooyinka xayawaanka iyo unugyada ee kansarka mindhicirka, 'phenethyl caffeate' waxay kicisaa apoptosis waxayna horjoogsataa koritaanka unugyada iyo burooyinka.
Wakiilka Antineoplastic
Walax oo joojiya ama ka hortagaya kororka neoplasms.
wakiilka neerfaha
Xarun kasta oo loo isticmaali karo daaweynta cudurada neerfayaasha.
wakiilka anti-bararka
Xarun kasta oo leh saameyn ka hortag ah.
difaaca jirka
Walax bayooloji ahaan firfircoon oo hawshoodu saamayn ku leedahay ama door ka ciyaaraysa shaqeynta nidaamka difaaca jirka.
Caffeate Phenethyl Caffeate Baaris dheeraad ah
Phenethyl caffeate waa walxo kiimikaad oo dabiici ah. Waa lafdhabarta loo yaqaan 'caffeic acid' iyo khamriga 'phenethyl khamriga'.
Noocyo kala duwan oo dawooyinka loo yaqaan 'vitrology' iyo dawooyinka ku dhaca moodooyinka xayawaanka ayaa looga warbixiyay kafeega Phenethyl, laakiin muhiimada caafimaadkooda lama oga. Waxay leedahay antimitogenic, anticarcinogenic, anti-bararka, iyo sifooyinka immunomodulatory ee ku jira vitro. Daraasad kale ayaa sidoo kale muujisay in maadada 'Phenethyl caffeate' ay xakameyso jawaab-celinta deg-degga ah iyo jawaab-celinta bararka ee ku jirta vitro. Saamaynta ka hortagga kansarka ayaa sidoo kale la arkay markii maqaarka jiirarka lagu daweeyo propolis shinnida isla markaana loo soo gaabiyo TPA, kiimikad sababa papillomas maqaarka. Kafeega Phenethyl wuxuu si weyn hoos ugu dhigay tirada papillomas-ka.
Tixraac Caffeate Phenethyl
Yang JW, Jung WK, Lee CM, iyo al. Caffeic Ester phenethyl acid waxay joojisaa saameynta bararka interleukin-1β ee fibroblasts corneal corneal. Immunopharmacol Immunotoxicol. 2014 Oct;36 (5):371-7. PMID: 25151996.
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