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Piceatannol budada 10083-24-6

Budada Piceatannol Magaca Macluumaadka Saldhigga Kiimikada Piceatannol CAS 10083-24-6 Nadiifinta 98% Magaca kiimikada 3,4,3′,5′-Tetrahydroxy-trans-stilbene Synonyms 3-Hydroxyresveratol (E) -4-(3,5-dihydroxystyryl) benzene-1,2-diol 3,5,3′,4′-Tetrahydroxystilbene Molecular Formula C14H12O4 Miisaanka Molecular 244.24 Boling Point / InChI Furaha CDRPUGZCRXZLFL-OWOJBTEDSA-N Foomka [...]

Caqligu wuxuu awood u leeyahay inuu soo saaro oo uu bixiyo tiro badan. Dhammaan wax soo saarka ee hoos yimaada xaaladda cGMP iyo nidaamka xakamaynta tayada adag, dhammaan dukumeentiyada imtixaanka iyo muunada la heli karo.
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Budada Piceatannol Macluumaadka Saldhigga Kiimikada

magaca Piceatannol
CAS 10083-24-6
xagiisayna 98%
Magaca kiimikada 3,4,3′,5′-Tetrahydroxy-trans-stilbene
Isku mid ahaanshaha 3-Hydroxyresveratol

(E) -4- (3,5-dihydroxystyryl) benzene-1,2-diol

3,5,3′,4′-Tetrahydroxystilbene

Formula kelli C14H12O4
Miisaanka kelli 244.24
Barta Boling /
Muhiimadda InChI CDRPUGZCRXZLFL-OWOJBTEDSA-N
Form budo
Imaanshaha Midab khafiif ah oo huruud ah
Nolosha badh  
milmi H2O: 0.5 mg / mL

DMSO: 10 mg / mL

ethanol: 10 mg/mL

kaydinta Xaaladda 2-8 ° C
Codsiga fiitamiinno
Dukumentiga Tijaabinta Available

 

Piceatannol budada 10083-24-6 General Description

Budada Piceatannol iyo glucoside, astringin, waa xeryahooda phenolic ee laga helo mycorrhizal iyo xididada aan mycorrhizal ee Norway spruces (Picea abies).Waxa kale oo laga heli karaa iniinaha timirta Aiphanes horrida iyo Gnetum cleistostachyum. Piceatannol waa dheef-shiid kiimikaad ee resveratrol oo laga helo khamriga cas, canabka, khudaarta, shaaha cad, iyo knotweed Japanese.

Piceatannol waa anti-bararka, immunomodulatory iyo wakiilka antiproliferative. Waxay joojisaa p56lck iyo syk borotiinka tyrosine kinases waxayna joojisaa firfircoonida NF-κB iyo muujinta hidda-wadaha ee TNF-ku-dhacday.

 

Piceatannol budada 10083-24-6 History

Labaatan sano ka hor, hydroxystilbenes piceatannol iyo transresveratrol ayaa laga helay, daraasad ku saabsan awoodda antioxidant ee alaabada dabiiciga ah, si loo joojiyo kansarka-ku-jirta horumarinta dhaawaca preneoplastic ee qaabka dhaqanka xubnaha qanjidhada naasaha ee murine. Piceatannol si dabiici ah ayuu ugu jiraa dhir kala duwan waana qayb firfircoon oo ka mid ah dhowr. Waxaa la og yahay in ay soo bandhigto hawlo badan oo bayooloji ah, oo ay ku jiraan antioxidant, bakteeriyada, anti-bararka, iyo hawlaha kansarka. U dhalatay koonfurta iyo koonfurta bari ee Aasiya, Rhodomyrtus tomentosa ( rose myrtle, oo xubin ka ah qoyska Myrtaceae), kaas oo lagu isticmaalay dawo dhaqameed ee Shiinaha, Malaysiya, iyo Vietnam calaamado badan oo ay ku jiraan bogsashada dhaawaca, waxaa ku jira piceatannol oo ah qayb firfircoon. .

 

Piceatannol budada 10083-24-6 Mfarsamada Of Action

Sidee ayuu Piceatannol uga shaqeeyaa jidhka? Piceatannol waa anti-bararka, immunomodulatory, iyo anti-proliferative stilbene kaas oo lagu muujiyay inuu faragelinayo dariiqa calaamadaha cytokine.

Piceatannol, oo hore loo soo sheegay inuu yahay horjooge door ah oo ah borotiinka tyrosine kinase Syk, waa qaab ahaan isku mid ah resveratrol. Haddii piceatannol uu sidoo kale xakameyn karo firfircoonida NF-κB ayaa la baaray. Daawaynta unugyada myeloid ee bini'aadamka ee piceatannol waxay xakamaysay TNF-ku-hawlgalayaasha DNA-da ee NF-κB. Taas bedelkeeda, stilbene ama rhaponticin (analoog kale oo piceatannol ah) wax saameyn ah kuma yeelan, taasoo soo jeedinaysa doorka muhiimka ah ee kooxaha hydroxyl. Saamaynta piceatannol laguma xaddidin unugyada myeloid, maaddaama firfircoonida TNF-ku-hawlgaliyay NF-kB sidoo kale lagu xakameeyay unugyada lymphocyte iyo epithelial.

Piceatannol sidoo kale waxay joojisay NF-κB oo ay dhaqaajisay H2O2, PMA, LPS, okadaic acid, iyo ceramide. Piceatannol wuxuu tirtiray muujinta TNF-ku-tiirsan ee NF-κB-ku-tiirsanaanta wariye-ku-tiirsanaanta iyo matrix metalloprotease-9, cyclooxygenase-2, iyo cyclin D1. Markii la baaro habka, waxaan ogaanay in piceatannol uu joojiyay TNF-ku-soo-baxa IκBα phosphorylation, p65 phosphorylation, p65 nukliyeerka nukliyeerka, iyo IκBα kinase activation, laakiin wax saameyn ah kuma yeelan hoos-u-dhaca IκBα.

Piceatannol wuxuu joojiyay NF-κB unugyada leh Syk la tirtiray, taas oo muujinaysa la'aanta ku lug la'aanta kinase this.

Guud ahaan, natiijooyinkayagu waxay si cad u muujinayaan in kooxaha hydroxyl ee stilbenes ay yihiin kuwo muhiim ah iyo in piceatannol, tetrahydroxystilbene, ay xakamayso firfircoonida NF-kB ee ay keento wakiilada kala duwan ee bararka iyada oo loo marayo xakamaynta IκBα kinase iyo p65 fosfooraska.

 

Piceatannol budada 10083-24-6 Codsiga

Budada Piceatannol waa shayga ugu muhiimsan ee loo isticmaalo kaabsiyada cuntada, kaabsal iyo kaabsaalo kale oo caafimaad.

 

Piceatannol budada 10083-24-6 Faa'iidooyinka

Faa'iidooyinka piceatannol waxaa ka mid noqon kara:

  1. Piceatannol waa Syk inhibitor si fiican loo yaqaan wuxuuna yareeyaa muujinta iNOS ee ay keentay TNF.
  2. Piceatannol waa wakiil waxtar u leh cilmi-baarista dhaawaca sambabada degdega ah (ALI).
  3. Piceatannol waa stilbene polyphenolic si dabiici ah u dhacda oo laga helo miraha iyo khudaarta kala duwan waxayna soo bandhigtaa sifooyinka kansarka iyo ka hortagga bararka.
  4. Piceatannol wuxuu keenaa apoptosis ee khadadka unugyada DLBCL.
  5. Piceatannol wuxuu keenaa autophagy iyo apoptosis ee MOLT-4 unugyada leukemia ee aadanaha.
  6. Daraasadaha taageeraya saameynta daaweynta ee suurtogalka ah ee piceatannol ee cudurada dheef-shiid kiimikaadka, oo ay ku jiraan xakameynta adipogenesis iyo dheef-shiid kiimikaadka ee adipocytes, iyo nidaaminta hyperlipidemia, hyperglycemia, caabbinta insulin, iyo bararka acid dufanka leh iyo cadaadiska oksida.

 

Piceatannol Vs Resveratrol: Waa maxay isku midka, kala duwanaanshaha?

  1. Piceatannol Vs Resveratrol

Resveratrol, 3,4′,5-trihydroxy-trans-stilbene, waa stilbenoid polyphenolic caan ah oo ku jira khamri cas.

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene, waa analoog oksijiin leh oo resveratrol ah.

 

  1. Piceatannol oo leh bioavailability ka sarreeya marka loo eego resveratrol

Resveratrol waxay ka ilaalisaa noocyada ogsijiinta fal-celiska ah (ROS) ee cudurrada la xidhiidha iyada oo la hawlgelinayo SIRT1, NAD +-ku-tiirsan deacetylase. Si kastaba ha noqotee, bioavailability hoose ee resveratrol waxay xaddidaysaa codsiyadeeda daweynta. Maadaama piceatannol uu yahay analoogga hydroxyl ee resveratrol oo leh bioavailability sare, waxay noqon kartaa beddelka resveratrol.

 

  1. Saamaynta ilaalinta Piceatannol ayaa ka sareysa resveratrol

Piceatannol iyo resveratrol waxay ku kala duwanaayeen cytotoxicity, hawlaha oxidant-scavening, iyo hababka cytoprotection. Ka ilaalinta piceatannol ee ka dhanka ah apoptosis ee ay keentay noocyada ogsijiinta falcelinta ayaa ka sareysa tan resveratrol. Marka lagu daro dariiqa sirtuin 1-ku-tiirsanaanta, piceatannol wuxuu sameeyay nukliyeerka nukliyeerka erythroid 2-related factor 2 / heme oxygenase-1-dhexdhexaadiyaha antioxidative iyo saameynta antiapoptotic, taas oo noqon karta faa'iido piceatannol marka la barbardhigo resveratrol.

 

Soo iibso Piceatannol iyo budada Resveratrol

Resveratrol waa ka hortagga kansarka kaas oo laga helo khamriga cas. Piceatannol waa stilbene xiriir dhow leh oo leh firfircoonida antileukaemic sidoo kale waa tyrosine kinase inhibitor. Piceatannol wuu ka duwan yahay resveratrol isagoo leh koox hydroxy dheeraad ah oo udgoon.

Wisepowder waa soo-saare diiradda saaraya cilmi-baarista, wax-soo-saarka iyo hal-abuurka alaabta ceeriin ee nootropics, nafaqada nafaqada iyo gabowga ka hortagga ... iwm. Sii labada PIceatannol iyo budada resveratrol oo leh tiro badan oo kayd ah. Ka iibso Piceatannol iyo budada resveratrol ee Wisepowder, tayada iyo adeeggu waa dammaanad.

 

Piceatannol budada 10083-24-6 Tixraaca

  1. Kwon, JY; Seo, SG; Hey, Y.-S.; Yuu, S.; Cheng, J.-X.; Lee, KW; Kim, K.-H. (2012). "Piceatannol, Polyphenolic Stilbene ee Dabiiciga ah, Waxay ka hortagtaa Adipogenesis iyada oo loo marayo Modulation of Mitotic Clonal Expansion iyo Insulin-ku-tiirsanaanta Insulin-ku-tiirsanaanta Calaamadaha Wajiga Hore ee Kala-duwanaanta". Joornaalka Kiimikada Nafleyda. 287 (14): 11566- doi:10.1074/jbc.M111.259721. PMC 3322826. PMID 22298784.
  2. Yao, Chun-Suo; Lin, Mao; Liu, Xin; Wang, Ying-Hong (2005). "Stilbene derivatives ka Gnetum cleistostachyum". Joornaalka Cilmi-baarista Alaabooyinka Dabiiciga ah ee Aasiya. 7 (2): 131– doi:10.1080/10286020310001625102. PMID 15621615.
  3. Nichols, TC, TH Fischer, EN Deliargyris, AS Baldwin, Jr. 2001. Doorka nukliyeerka κB (NF-κB) ee caabuqa, periodontitis, iyo atherogenesis. Ann. Periodontol. 6: 20CrossRefPubMed
  4. Al-Ramadi, BK, T. Welte, MJ Fernandez-Cabezudo, S. Galadari, B. Dittel, XY Fu, AL Bothwell. 2001. Src-protein tyrosine kinase Lck ayaa looga baahan yahay calaamadaynta kharashka dhexdhexaadka ah ee IL-1 ee unugyada Th2. J. Immunol. 167: 6827
  5. Manna, SK, NK Sah, BB Aggarwal. 2000. Protein tyrosine kinase p56lck ayaa looga baahan yahay ceramide-ku-soo-baxa laakiin ma aha jawaabaha unugyada TNF-ku-soo-baxa: saameynta firfircoonida NF-κB, AP-1, JNK iyo apoptosis. J. Biol. Chem. 275: 13297